当前位置: 首页  师资队伍  教师风采  教授
基本信息
陈 文

学  位:博士

导师情况:博导、硕导

研究方向:生物化学、分析化学、蛋白工程、纳米技术、食品生物技术

联系电话:

电子邮箱:wenchen@scut.edu.cn

通讯地址:东莞庄路华南理工大学北区化机四号楼311

个人简介

陈文,博士,教授,博士生导师。曾师从陈章良,提前1年从中国农业大学获得本科学位,后加入美国仁斯利尔理工学院并于2012年获得博士学位。陈文博士拥有在默克药厂和Flagship Pioneering投资公司的工作经历,并先后在汉密尔顿学院、哈佛医学院担任博士后、特 聘科学家和研究员,2021年加入华南理工大学食品科学与工程学院。

近年来,在大量的核磁共振和蛋白质工程的基础上,陈文博士以生物膜蛋白质为研究对象,结合纳米技术,发明了新型脂质体复合物的组装方法,并以此为基础优化抗体和小分子的体外筛选;同时发展了核酸适体的筛选平台,并完善了大分子和小分子的检测体系。多次在Nature、Cell、Nature Protocols、Nature Communications、Angew Chem、JACS等顶级期刊发表论文,拥有重要专利,受到美国农业部和美国垦务局的嘉奖。并获得过哈佛医学院华人生命科学杰出科研奖和中华海外磁共振协会年度科学家奖。长期受邀担任多家知名国际学术期刊的审稿人,包括JACS 、Medicinal Chemistry 、Bioinformatics、Journal of Neurochemistry、Journal of Lipid Research、Plos Computational Bilogy、International Journal of Molecular Sciences、 Journal of Biophysics、Applied Microbiology and Biotechnology、Biochemistry、Plos One、Journal of Theoretical Biology等超过15家学术期刊。

科研项目


代表学术论文

1.Alessandro Piai, Qingshan Fu, Yongfei Cai, Fadi Ghantous, Tianshu Xiao, MdMunan Shaik, Hanqin Peng, Sophia Rits-Volloch, Wen Chen, Michael S Seaman, Bing Chen, James J Chou. “Structuralbasis of transmembrane coupling of the HIV-1 envelope glycoprotein” NatureCommunications, 2020, 11;2317

2. Haotian Liao, Wen Chen, Yunlu Dai, Joseph J Richardson, Junling Guo, Kefei Yuan,Yong Zeng, Kunlin Xie. “Expression of programmed cell death-ligands inhepatocellular carcinoma: correlation with immune microenvironment and survivaloutcomes” Frontiers in oncology, 2019, 9, 883

3.Wen Chen, Bo Ouyang, James J Chou. “Critical Effect of the Detergent:Protein Ratio on the Formation of the Hepatitis C Virus p7 Channel” Biochemistry,2019, 58 (37), 3834-3837

4.Wen Chen, Junling Guo, Yongfei Cai, Bill Fu, James J Chou. “Unidirectionalpresentation of membrane proteins in nanoparticle-supported liposomes” AngewandteChemie, 2019, 58, 9866-9870 (witha cover Illustration)

5. Qingshan Fu*, Alessandro Piai*,Wen Chen*, Ke Xia, JamesChou. “Structure Determination Protocol for Oligomeric Transmembrane Domains” NatureProtocols, 2019, 14, 2483-2520 (Co-firstauthor)

6. Liqiang Pan⃰, Tianming Fu⃰,Linlin Zhao⃰, Wen Chen, Wenhui Liu,Zhijun Liu, Alessandro Piai, Qingshan FU, Shuqing Chen, Hao Wu, James J Chou.“Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling” Cell,2019, 176 (6), 1477-1489. e14

7. Ke Li, Yunlu Dai, Wen Chen, Kang Yu, Gao Xiao, Joseph J Richardson, Wen Huang,Junling Guo, Xuepin Liao, Bi Shi. “Self‐Assembled Metal‐Phenolic Nanoparticles for Enhanced Synergistic Combination Therapyagainst Colon Cancer” Advanced Biosystems, 2019, 3 (2),1800241

8. Wen Chen, Bo OuYang, James Chou.“Re-evaluating the p7 viroporin structure reply” Nature, 2018562, E19-E20

9. WenChen, Jyoti Dev, Julija Mezhyrova, Liqiang Pan, Alessandro Piai, James JChou. “The Unusual Transmembrane Partition of the Hexameric Channel of theHepatitis C Virus” Structure. 2018, 26(4), 627-634, e4

10. Wen Chen, Eric Gamache, DavidRosenman, Xie Jian, Lopez Marimar, Yue-Ming Li, Chunyu Wang. “FamilialAlzheimer's mutations within APPTM increase Aβ42 production by enhancingaccessibility of ε-cleavage site” Nature Communications, 2014Jan 6;5:3037

11. WenChen, Myriam Cotton. “Expression, purification, and micelle reconstitutionof Antimicrobial Piscidin 1 and Piscidin 3 for NMR studies” ProteinExpr Purif, 2014 Oct, 102: 63-68

12. David J Rosenman, Christopher RConnors, Wen Chen, Chunyu Wang,Angel E García. “Aβ monomers transiently sample oligomer and fibril-like configurations:ensemble characterization using a combined MD/NMR approach” Journalof Molecular Biology, 2013, 425 (18), 3338-3359

13. Wen Chen, Lingyun Li, ZhenmingDu, Jiajing Liu, Julie N. Reitter, Kenneth V. Mills, Robert J. Linhardt, andChunyu Wang. “Intramolecular Disulfide Bond between Catalytic Cysteines in anIntein Precursor” J. Am. Chem. Soc., 2012, 134 (5),pp 2500–2503

14. WenChen, Eric Gamache, Danielle Richardson, Zhenming Du, and Chunyu Wang. “Expression,purification, and reconstitution of the transmembrane domain of the humanamyloid precursor protein for NMR studies” Protein Expr Purif, 2012Jan;81(1):11-7

15.Zhenming Du, Jiajing Liu, Clayton D Albracht, Alice Hsu, Wen Chen, Michelle D Marieni, Kathryn M Colelli, Jennie E Williams,Julie N Reitter, Kenneth V Mills, Chunyu Wang. “Structural and mutationalstudies of a hyperthermophilic intein from DNA polymerase II of Pyrococcusabyssi” Journal of Biological Chemistry, 2011, 286 (44), 38638-38648 (with a cover Illustration)
获奖

1. 2018年, 设计并证明了鉴定半乳糖凝集素抑制剂的方法,获得美国开放式创新研究公司InnoCentive颁发的创新奖。

2. 2018年,提出消灭开放水域中有害贝类生物的可行性方案,获得美国垦务局颁发的环保治理奖。

3. 2017年,帮助美国农业部设计并研发抗生素的高效替代物以治疗并防御奶牛乳腺炎,该设计被评为最佳设计奖。

4. 2015年,获得哈佛医学院授予的哈佛医学院华人生命科学杰出科研奖。

5. 2014年,获得中华海外磁共振协会授予的中华海外磁共振协会年度科学家奖


教授

联系方式

学院办公室:020-87113126
科研工作:020-87114218
教务工作:020-87110738
实验室管理:020-87113034
本科学工:020-87113037
组织人事:020-22236011