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关于举办新加坡南洋理工大学Yonggui Gao教授学术讲座的通知
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发布时间:2021-06-10 23:48:52
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讲座题目:Understanding molecular mechanism of cellulosebiosynthesis towards its application development

讲座形式:线上与线下相结合

讲座时间:2021年6月15日11:00—12:00(线上)

报告会地点:13号楼二楼东糖厅(线下)

报告人:Yonggui Gao 博士,Tenured副教授(新加坡南洋理工大学)

参会须知:(1)应疫情防控需要,线下参会人数限制在30人以内,将按当天实际到场顺序控制人数。(2)参会师生必须严格遵守疫情防控相关规定,14天内无中高风险地区旅居史,进入线下会场请配合核查健康码,会议期间请全程佩戴口罩,隔位就座。(3)当天有发热、咳嗽、咽痛等症状的师生不得进入线下会场。


欢迎广大师生参加!

 

食品科学与工程学院

2021年6月10日

报告人简介:

Yonggui Gao,博士,新加坡国立研究基金获得者,现为南洋理工大学生物科学学院Tenured副教授和新加坡科技研究局细胞分子研究所资深研究员, 研究专长为结构生物学和蛋白质化学。目前主要从事核糖体结构与功能,以核糖体为靶位的抗生素作用机理及新型药物的设计研究;以DNA/RNA修饰所引发的人类疾病(如肥胖基因FTO)相关基因的调控和拮抗剂的研制,以及细胞分泌多糖的生物学合成和开发利用等。已在Science, Cell, Nature Structural & Molecular Biology, PNAS等高水平杂志上发表多篇论文,其中多篇被杂志封面所报道, 包括Science, Cell, JBC, Chemical Sciences等。目前担任ScientificReports等杂志编委。

报告摘要:

As the most abundant biopolymer in Earth, cellulosehas many potential industrial applications, such as the source of renewableenergy. Cellulose is synthesized by the synthase of the GlycosyltransferaseGT-2 family. In bacteria, the cellulose synthase (CESA) is composed of severalhetetro-subunits that form a complex (also called terminal complex) tosynthesize and extrude glucan chain. In land plants, cellulose is produced atthe plasma membrane by six-lobed rosette-shaped CESA complexes (CSCs) whereeach CESA is thought to synthesize one cellulose chain. Bacterial cellulose isnot essential. In contrast, plant cellulose is absolutely required, which is anessential component for cell wall formation. While plant cellulose’s biologicalfunctions are relatively well understood, molecular details of how cellulose isproduced remain largely unknown. Very recently, atomic structural informationhas closed this gap to some extent, and greatly advanced our understanding ofits biosynthesis. In this talk, we will be introducing these exciting progress,in particular our structures of Arabidopsis thaliana CESA3, in apo andsubstrate UDP-glucose bound form.