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基本信息
黄泽波

学  位:博士

导师情况:博导、硕导

研究方向:食品营养与健康、活性多糖与多肽、衰老与相关疾病

联系电话:

电子邮箱:huangzebo@scut.edu.cn

通讯地址:广州市番禺区大学城华南理工大学B8栋

个人简介

现任华南理工大学食品科学与工程学院教授、博士生导师,世界中医药学会联合会李时珍医药研究与应用专业委员会副会长、中国药学会生化与生物技术药物专业委员会委员。1985年于北京农业大学(今中国农业大学)生物学院获学士学位,1997年于中国科学院水生生物研究所获博士学位。曾先后在法国国家科研中心和图卢兹大学水生生物学联合实验室、挪威奥斯陆大学药学院、美国弗吉尼亚理工学院生物技术中心、英国伯明翰大学生物科学学院、英国剑桥大学生物技术研究所等欧美知名学府学习和工作近10年。曾任武汉大学药学院教授、博士生导师、生物药物研究所所长,武汉大学食品与药品评价研究中心副主任,广东药科大学教授、生命科学与生物制药学院院长、教务处处长。目前主要从事生物活性多糖与分子糖生物学、活性蛋白与多肽规模化筛选、衰老与神经退行性疾病等研究与开发,建立了基于细胞和秀丽线虫模型的高通量筛选与评价平台。申请专利20余项,其中授权发明专利10余项。发表科研和教学论文80余篇,论文总引用数2300余次。担任科学出版社规划教材《生物技术制药》主编、人民卫生出版社规划教材《药学分子生物学》副主编。

科研项目

主持国家国际科技合作专项项目、国家863计划探索导向类课题、国家科技支撑计划专题课题、国家自然科学基金项目、英国生物技术与生物科学研究委员会国际合作项目(中方负责人)、挪威国家科研理事会国际合作项目(中方负责人)、与生物医药企业的合作研发项目等各类科研课题数十项。

代表学术论文

1.Haifeng Li, Linnan Su, Sheng Chen, Libin Zhao, Hongyu Wang, Fei Ding, Hong Chen, Ruona Shi, Yulan Wang & Zebo Huang (2018). Physicochemical characterization and functional analysis of the polysaccharide from the edible microalga Nostoc sphaeroides. Molecules 23, 508 (17 pages); doi:10.3390/molecules23020508.

2.Yanxia Xiang, Ju Zhang, Haifeng Li, Qiangqiang Wang, Lingyun Xiao, Huandi Weng, Xiaobin Zhou, Chung Wah Ma, Fangli Ma, Minghua Hu & Zebo Huang (2017). Epimedium polysaccharide alleviates polyglutamine-induced neurotoxicity in Caenorhabditis elegans by reducing oxidative stress. Rejuvenation Research 20: 32–41.

3.Haifeng Li, Fei Ding, Lingyun Xiao, Ruona Shi, Hongyu Wang, Wenjing Han & Zebo Huang (2017). Food-derived antioxidant polysaccharides and their pharmacological potential in neurodegenerative diseases. Nutrients 9, 778 (26 pages); doi: 10.3390/nu9070778.

4.Haifeng Li, Wenjing Han, Hongyu Wang, Fei Ding, Lingyun Xiao, Ruona Shi, Liping Ai & Zebo Huang (2017). Tanshinone IIA inhibits glutamate-induced oxidative toxicity through prevention of mitochondrial dysfunction and suppression of MAPK activation in SH-SY5Y human neuroblastoma cells. Oxidative Medicine and Cellular Longevity Vol. 2017, Article ID 4517486 (13 pages); doi: 10.1155/2017/4517486.

5.Jing Chen, Ju Zhang, Yanxia Xiang, Limin Xiang, Yongmei Liu, Xiangjiu He, Xiaoju Zhou, Xin Liu & Zebo Huang (2016). Extract of Tsai Tai (Brassica chinensis): Enhanced antioxidant activity and anti-aging effects both in vitro and in Caenorhabditis elegans. Food & Function 7: 943–952.

6.Haifeng Li, Ruona Shi, Fei Ding, Hongyu Wang, Wenjing Han, Fangli Ma, Minghua Hu, Chung Wah Ma & Zebo Huang (2016). Astragalus polysaccharide suppresses 6-hydroxydopamine-induced neurotoxicity in Caenorhabditis elegans. Oxidative Medicine and Cellular Longevity Vol. 2016, Article ID 4856761 (10 pages); doi: 10.1155/2016/4856761.

7.Ju Zhang, Ruona Shi, Haifeng Li, Yanxia Xiang, Lingyun Xiao, Minghua Hu, Fangli Ma, Chung Wah Ma & Zebo Huang (2016). Antioxidant and neuroprotective effects of Dictyophora indusiata polysaccharide in Caenorhabditis elegans. Journal of Ethnopharmacology 192: 413–422.

8.Qiangqiang Wang, Yunxuan Huang, Chuixin Qin, Ming Liang, Xinliang Mao, Shuiming Li, Yongdong Zou, Weizhang Jia, Haifeng Li, Chung Wah Ma & Zebo Huang (2016). Bioactive peptides from Angelica sinensis protein hydrolyzate delay senescence in Caenorhabditis elegans through antioxidant activities. Oxidative Medicine and Cellular Longevity Vol. 2016, Article ID 8956981 (10 pages); doi: 10.1155/2016/8956981.

9.Haifeng Li, Fangli Ma, Minghua Hu, Chung Wah Ma, Lingyun Xiao, Ju Zhang, Yanxia Xiang & Zebo Huang (2014). Polysaccharides from medicinal herbs as potential therapeutics for aging and age-related neurodegeneration. Rejuvenation Research 17: 201–204.

10.Lingyun Xiao, Haifeng Li, Ju Zhang, Fan Yang, Aizhen Huang, Jingjing Deng, Ming Liang, Fangli Ma, Minghua Hu & Zebo Huang (2014). Salidroside protects Caenorhabditis elegans neurons from polyglutamine-mediated toxicity by reducing oxidative stress. Molecules 19: 7757–7769.

11.Qiangqiang Wang, Fan Yang, Wei Guo, Ju Zhang, Lingyun Xiao, Haifeng Li, Weizhang Jia & Zebo Huang (2014). Caenorhabditis elegans in Chinese medicinal studies: Making the case for aging and neurodegeneration. Rejuvenation Research 17: 205–208.

12.Liang Qiao, Sang Luo, Yongding Liu, Xiaoyan Li, Gaohong Wang & Zebo Huang (2013). Reproductive and locomotory capacities of Caenorhabditis elegans were not affected by simulated variable gravities and spaceflight during the Shenzhou-8 mission. Astrobiology 13: 617–625.

13.Shibin Ai, Tao Jia, Weilun Ai, Jianli Duan, Yongmei Liu, Jing Chen, Xin Liu, Fan Yang, Yuan Tian & Zebo Huang (2013). Targeted delivery of doxorubicin through conjugation with EGF receptor–binding peptide overcomes drug resistance in human colon cancer cells. British Journal of Pharmacology 168: 1719–1735.

14.Qing Zhu, Chaolin Liao, Yongmei Liu, Pengcheng Wang, Wei Guo, Meijun He & Zebo Huang (2012). Ethanolic extract and water-soluble polysaccharide from Chaenomeles speciosa fruit modulate lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophage cells. Journal of Ethnopharmacology 144: 441–447.

15.Xiliang Yang, Peng Zhang, Jizhou Wu, Siqin Xiong, Nanxiang Jin & Zebo Huang (2012). The neuroprotective and lifespan-extension activities of Damnacanthus officinarum extracts in Caenorhabditis elegans. Journal of Ethnopharmacology 141: 41–47.

16.Hanrui Zhang, Ni Pan, Siqin Xiong, Shenglong Zou, Haifeng Li, Lingyun Xiao, Zhijian Cao, Alan Tunnacliffe & Zebo Huang (2012). Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochemical Journal 441: 417–424.

17.Shibin Ai, Jianli Duan, Xin Liu, Stephanie Bock, Yuan Tian & Zebo Huang (2011). Biological evaluation of a novel doxorubicin-peptide conjugate for targeted delivery to EGF receptor-overexpressing tumor cells. Molecular Pharmaceutics 8: 375–386.

18.Haifeng Li, Zhangwei Li, Siqin Xiong, Hanrui Zhang, Na Li, Shuanghui Zhou, Yongmei Liu & Zebo Huang (2011). Pilot-scale isolation of bioactive extracellular polymeric substances from cell-free media of mass microalgal cultures using tangential-flow ultrafiltration. Process Biochemistry 46(5): 1104–1109.

19.Haifeng Li, Juan Xu, Yongmei Liu, Shibin Ai, Fen Qin, Zhangwei Li, Hanrui Zhang & Zebo Huang (2011). Antioxidant and moisture-retention activities of the polysaccharide from Nostoc commune. Carbohydrate Polymers 83: 1821–1827.

20.Zebo Huang, Matthew C. Banton & Alan Tunnacliffe (2010). Modeling anhydrobiosis: activation of the mitogen-activated protein kinase ERK by dehydration in both human cells and nematodes. Journal of Experimental Zoology 313A: 660–670.

获奖

曾获省部级学术奖励和荣誉5项,包括首届湖北省优秀博士学位论文、湖北省自然科学二等奖、广东省南粤优秀教师等奖项。

教授

联系方式

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