娄文勇，教授、博士生导师、华南理工大学城乡高质量发展副院长（正处）、“全国百篇优秀博士学位论文“作者、国家优青（首届）、广东省特支计划百千万工程领军人才以及教育部新世纪优秀人才，连续多年入选全球前2%顶尖科学家榜单；获广东省科技进步奖一等奖（排名第1, 2025）、东京国际发明专利奖金奖（排名第2, 2025），国际遗传工程机器大赛（iGEM）金奖（指导老师，2025, 2017）、广东省自然科学奖二等奖（排名第2, 2014）、中国轻工业联合会先进个人奖（2012）以及中国石化工业联合会青年科技突出贡献奖（2018）。研究方向为食品合成生物学与生物制造、益生菌的挖掘与健康效应机制、食品安全与营养健康等。承担过国家重点研发计划，国家自然科学基金、广东省重点研发计划、校企合作项目等40余项。在Nat.Commun.（3）,Nat. Synth.(1), Microbiome, Coordin. Chem. Rev., Biotechnol. Adv., Chem. Eng.J., Food Hydrocoll., J. Agr. Food Chem.等刊物上发表了150余篇论文(ESI高被引论文7篇，封面论文11篇)，他引9000余次，h因子50；担任FoodWellness主编，Frontiers in Bioengineering and Biotechnology,Frontiers in Microbiology副主编，Bioresources andBioprocessing和《中国食品科技》等刊物编委；获授权中国发明专利58件（PCT美国专利3件），转让专利12件；主编中英文专著4部，参编中英文专著6本；多项科研成果已实现了产业化推广及应用。

1）国家重点研发计划（课题）：固定化酶催化过程强化与长效循环策略, 2021YFC2102804

2）国家自然科学基金面上：非天然合成途径驱动的萜类化合物高效合成平台构建及其分子机制研究，22578142

3）国家自然科学基金面上：牛大力内生真菌多糖的生物合成及其调控机制研究，22078111

4）国家自然科学基金面上：基于代谢工程改造的增强型大肠杆菌工程菌的构建及应用研究，21878105

5）广东省重点研发计划项目：高效工程酶生物制备及其催化合成产品的研发，B2250030

6）国家自然科学基金面上：脂氧合酶人工酶催化机制及其与天然酶协同催化芳香醛及衍生物合成研究, 22378146

7）国家重点研发计划（子课题）：脂质定向可控生物转化用酶的定向挖掘和稳定性分子改造, 2022YFD2101400

8）国家重点研发计划（子课题）：食品安全检验在线质控系统研究，2018YFC1603400

9）国家自然科学基金面上：深度共熔溶剂中环氧化物水解酶催化环氧化物不对称水解反应的研究，21676104

10) 广州市重点研发计划: 牛大力的食品功能因子挖掘及高值化利用, 2060404

11）国家优秀青年科学基金：新型非水介质中生物催化及生物质转化，21222606

12）企事业单位委托项目：坚果食品加工技术创新及产业化研究，D8203920

13）企事业单位委托项目：将尿酸潜在功能益生菌技术，20251735

14）企事业单位委托项目：澳洲坚果中Omega系列脂肪酸的提取富集技术和微胶囊制备技术开发及其活性研究，D8223060

15）企事业单位委托项目：生物酶转化技术制备稀有人参皂苷Rh/Rk系列，D8240340

16）企事业单位委托项目：鲟鱼关键活性成分的高效提取方法和工艺研究，D8224040

1.Li, M., Zhang,C.Y., Liang, H., Wu, B.Y., Yu, W.X., Li, G.J., Cao, Y.F., Lou, W.Y.*, Machine learning-guidedengineering of chalcone synthase enables high-selectivity phloretinbiosynthesis in yeast. Green Chemistry, 2025, 27, DOI:10.1039/d5gc03435c

2.Zhang,C., Cui, R., Qi, L., Zong, M.H., Zhang, C.Y., Cao, Y.F., Lou, W.Y.*, Agar-based Pickering emulsion: Aplatform for enzymatic and chemoenzymatic synthesis. Chemical Engineering Journal, 2025, 522,167562

3.Li, G.J., Liang, H., Gao, R.C., Xu, P., Huang, M.T., Zong,M.H., Cao, Y.F., Lou, W.Y.*, Yeast metabolism adaptation forefficient terpenoids synthesis via isopentenol utilization, NatureCommunications, 2024, 15, 9844.

4.Yuan, X.; Wu, X.L.*; Xiong, J.; Yan, B.H.; Gao, R.C.; Liu, S.L.; Zong,M.H.; Ge, J.*; Lou, W.Y.*, Hydrolase mimic via second coordinationsphere engineering in metal-organic frameworks for environmental remediation, NatureCommunications, 2023, 14, 5974

5.Liu, S.L.; Zhou, J.T.; Yuan, X.; Xiong, J.; Zong, M.H.; Wu, X.L.*;Lou, W.Y.*,Adual-mode sensing platform based on metal-organic framework for colorimetricand ratiometric fluorescent detection of organophosphorus pesticide, FoodChemistry, 2023, 432, 137272.

6.Xiong, J.; Chen, B.; Gu, Z.Y.; Liu, S.L.; Zong, M.H.; Wu, X.L.*; Lou,W.Y.*, Hierarchically open-capsule metal-organic frameworks via controlledetching for enzyme encapsulation. Chemical Engineering Journal, 2023,468, 143622.

7.Li, M.F.; Cui, H.L.; Lou, W.Y.*,Millettia speciosa Champ cellulose-basedhydrogel as a novel delivery system for Lactobacillus paracasei: Itsrelationship to structure, encapsulation and controlled release. Carbohydrate Polymers,2023, 316, 121034

8.Li, M.F.; Wu, X.L.; Guo, Z.W.; Gao, R.C.; Ni, Z.F. ; Cui, H.L.; Zong, M.H.; Van Bockstaele, F.; Lou,W.Y.*,Lactiplantibacillus plantarum enables blood uratecontrol in mice through degradation of nucleosides in gastrointestinal tract. Microbiome, 2023,11(1), 153.

9.Huang,Z.; Zong, M.H.; Lou, W.Y.*, Effect ofacetylation modification on the emulsifying and antioxidant properties ofpolysaccharide from Millettia Speciosa Champ. Food Hydrocolloids, 2022, 124, 107217.

10.Huang,Z.; Zeng, Y.J.; Wu, X.L.; Li, M.F.; Zong, M.H.; Lou, W.Y.*, Development of Millettia speciosa champ polysaccharide conjugatestabilized oil-in-water emulsion for oral delivery of β-carotene:Protection effect and in vitro digestion fate. Food Chemistry, 2022, 397,133764.

11.   Qi, L.;Lei, J.Q.; Gao, Q.Y.; Zhang, B.*; Lou, W.Y.*; Luo,Z.G., Surfactant-assisted synthesis of colloidosomes for positional assembly ofa bienzyme system. Chemical Engineering Journal, 2022,452, 139305.

12.Liang,S.; Wu, X.L.; Xiong, J.; Yuan, X.; Liu, S.L.; Zong, M.H.; Lou, W.Y.*,Multivalent Ce-MOFs as biomimeticlaccase nanozyme for environmental remediation. Chemical Engineering Journal, 2022, 450, 138

13.Zhang,L.S.*; Liu, R.B.; Zong, M.H.; Yang, J.G.; Lou, W.Y.*; Bi,Y.L., A comparative study of human milk fat substitute from Rhodococcusopacus and plant-oil based commercial products. Food Bioscience, 2022,50, 102031.

14.Wu,X.L.*; Xiong, J.;Liu, S.L.; Zong, M. H.; Lou, W. Y.*, Aversatile competitive coordination strategy for tailoring bioactive zeoliticimidazolate framework composites. Small, 2021, 17,2007586.

15.Xu, P.; Liang, S.; Zong, M. H.; Lou, W. Y.*,Ionic liquids for regulating biocatalytic process: achievements and perspectives.Biotechnology Advances, 2021, 29, 107702.

16.Wu, X.L.; Xiong, J.; Liu, S.L.; ChengJ.H.; Zong, M. H.;Lou, W.Y.*, Investigation of hierarchically porous zeoliticimidazolate frameworks for highly efficient dye removal. Journal ofHazardous Materials, 2021, 417, 126011.

17.Chen X.; Huang, Z.;Luo, S.Y.; Zong, M.H.; Lou, W.Y.*,Multi-functional magnetic hydrogels based on millettia speciosa champ residuecellulose and chitosan: highly efficient and reusable adsorbent for congo redand cu 2+ removal. Chemical Engineering Journal, 2021, 423, 130198.

18. Zhang, Z.H.; Li, M.F.; Peng, F.; Zhong, S.R.; Huang,Z.; Zong, M.H.; Lou, W.Y.*,Oxidizedhigh-amylose starch macrogel as a novel delivery vehicle for probiotic andbioactive substances. Food Hydrocolloids, 2021,114, 106578.

19.Zhong, S.R.;Li, M.F.; Zhang, Z.H.; Zong, M.H.; Wu, X.L.; Lou, W.Y.*, Novel antioxidativewall materials for Lactobacillus casei microencapsulation via theMaillard reaction between the soy protein isolate and prebiotic oligosaccharides.Journal of Agricultural and Food Chemistry, 2021, 69,13744.

20.Zhang,L.S.; Chu, M.Y.; Zong, M.H.; Yang, J.-G.; Lou,W.Y.*, Facile and greenproduction of human milk fat substitute through rhodococcus opacusfermentation. Journal of Agricultural and Food Chemistry, 2020, 68, 9368.

21.Liang, S.; Wu, X.L.; Xiong, J.;Zong, M.H.; Lou, W.Y.*, Metal-organic frameworks as novel matrices forefficient enzyme immobilization: An update review. Coordination ChemistryReviews, 2020, 406, 213149.

22.Guo,Z.W.; Ou, X.Y.; Xu, P.; Gao,H.F.;Zhang, L.Y.; Zong, M.H.; Lou,W. Y.*, Energy- and cost-effective non-sterilized fermentation of2,3-butanediol by an engineered Klebsiella pneumoniae OU7 with ananti-microbial contamination system. Green Chemistry, 2020, 22, 8584.

23.Guo,Z.W.; Ou, X.Y.; Liang, S.; Gao,H.F.; Zhang, L.Y.; Zong, M.H.; Lou, W.Y.*, Recruitinga phosphite dehydrogenase/formamidase-driven anti-microbial contaminationsystem in bacillus subtilis for non-sterilized fermentation of acetoin. ACSSynthetic Biology, 2020, 9, 2537.

24.Ni, Z.F.; Zeng, Y.J.; Xu, P.; Guo, Z.W.;Ou, X.Y.; Peng, F.; Yang, J.G.; Zong, M.H.; Lou, W.Y.*, Characterizationof a novel methylaspartate ammonia lyase from E. coli O157:H7 for efficientasymmetric synthesis of unnatural amino acids. ACS Sustainable Chemistry & Engineering, 2020, 8, 329.

25.Xu, P.; Ni, Z.F.; Zong, M.H.; Ou, X.Y.; Yang,J.G.; Lou, W.Y.*, Improving the thermostabilityand activity of Paenibacillus pasadenensis chitinase throughsemi-rational design. International Journal of BiologicalBiomacromolecules, 2020, 150, 9.

26. Liang, S.; Wu, X.L.; Zong, M.H.;Lou, W.Y.*, Zn-triazole coordination polymers:Bioinspired carbonic anhydrase mimics for hydration and sequestration of CO2.Chemical Engineering Journal, 2020, 398, 125530.

27. Su, H.H.; Guo, Z.W.; Wu, X.L.; Xu,P.; Li, N.; Zong, M.H.; Lou, W.Y.*, Efficient bioconversion of sucroseto high-value-added glucaric acid by in vitro metabolic engineering. ChemSusChem, 2019, 12, 2278.

28.Ou, X.Y.; Wu, X.L.; Peng, F.;Zeng, Y. J.; Li, H. X.; Xu, P.; Chen, G.; Guo, Z.W.; Yang, J.G.; Zong, M. H.*; Lou,W.Y.*, Metabolic engineering of a robust Escherichia coli strainwith a dual protection system. Biotechnologyand Bioengineering, 2019, 116, 3333.

29.Zeng, Y.J.; Yang, H.R.; Zong, M.H.; Yang,J.G.; Lou, W.Y.*, Novel antibacterial polysaccharides produced byendophyte Fusarium solani DO7. BioresourceTechnology,2019, 288, 121596.

30.Wu, X.L.; Huang, Z.X.; Cao,S.L.; Zong, M.H.; Lou, W.Y.*, Improving biocatalysis of cefaclor withpenicillin acylase immobilized on magnetic nanocrystalline cellulose in deepeutectic solvent based co-solvent. Bioresource Technology, 2019, 288, 121548.

1）2025年东京国际发明专利奖金奖

2）2025年国际遗传工程机器设计大赛（iGEM）金奖（指导老师）

3）2024年广东省科技进步奖一等奖

4）2018年中国石油和化学工业联合会青年科技突出贡献奖

5）2017年国际遗传工程机器设计大赛（iGEM）金奖（指导老师）

6）2014年获得广东省科学技术二等奖（自然科学类）

7）2012年获得中国轻工业联合会“十一五”科技创新先进个人奖

8）2009年获得全国百篇优秀博士学位论文奖