报告题目：Steric-on-Demand Phosphine Ligands for Tackling Highly Steric-Congested Cross-Coupling Processes

报 告 人：邝福儿（香港中文大学教授）

报告时间：2025年4月7日（星期一）上午9：00—10：30

邀 请 人：曾伟教授

报告地点：化学与化工学院逸夫工程馆四楼会议室

主办单位：化学与化工学院/广东省功能分子工程重点实验室

报告摘要：

Transition metal-catalyzed cross-coupling protocol has emerged as a highly versatile way for assembling creative and useful molecules.1 By proficiently manipulating the phosphine ligand chassis and thus adjusting the geometry of associated metal complexes, a diverse range of these cutting-edge processes has been successfully established as valuable synthetic schemes. Cross-coupling reactions leading to the generation of C(Ar)C(Ar’) biaryl axis in highly steric-hindered environment have presented significant challenges. The use of exceptionally bulky ligands can impede the approach of the substrate to the metal center, potentially diminishing the efficiency of substrate binding. Yet, these bulky ligands can facilitate the reductive elimination process, creating a dilemma in the selection of appropriate phosphine ligands for tackling extremely steric-congested cross-coupling reactions.

References

1. de Meijere, A.; Bräse, S.; Oestreich, M.; Eds.; Metal-Catalyzed Cross-Coupling Reactions and More, Vol.1-3, Wiley-VCH: Weinheim, 2014.

2. Tse, M. H.; Zhong, R.-L.; Kwong, F. Y. ACS Catal. 2022, 12, 3507.

3. Gan, K. B.; Zhong, R.-L.; Zhang, Z.-W.; Kwong, F. Y.  J. Am. Chem. Soc. 2022, 144, 14864.

4. Tse, M. H.; Choy, P. Y.; Kwong, F. Y. Acc. Chem. Res. 2022, 55, 3688.

报告人简介：

Scientific Vita

2001-2003：裘槎博士后，美国麻省理工学院，美国（导师：Prof. S. L. Buchwald） 

2004-2017：讲师~教授，应用生物及化学科技学系，香港理工大学，中国香港

2016-2017：副系主任，应用生物及化学科技学系，香港理工大学，中国香港

2017-现在：教授，化学系，香港中文大学，中国香港

2018-现在：主任，深圳新颖功能分子研究中心，深圳市药用有机小分子化学合成重点实验室，香港中文大学深圳研究院，中国香港

2020-现在：青年院士，香港科学院，中国香港

2021-现在：系主任，化学系，香港中文大学，中国香港

Research Field

Organometallic chemistry, design of phosphine ligands, enantioselective reactions

Awards and Recognition

2020Elected Member, The Hong Kong Young Academy of Sciences (香港青年科学院院士)

2019The Distinguished Lectureship Award, The CSJ Asian International Symposium, The Chemical Society of Japan

2014教育部高等学校科学研究优秀成果奖自然科学二等奖「新型膦配体的设计及其于偶联反应上的应用」（获奖人：邝福儿丶苏秋铭）

2013市级科技项目先进个人, 深圳市科技创新委员会

Representative Publications

1，Tse, M. H.; Choy, P. Y.; Kwong, F. Y. Facile Assembly of Modular-Type Phosphines for Tackling Modern Arylation Processes.  Acc. Chem. Res. 2022, 55, 3688. 

2，Gan, K. B.; Zhong, R.-L.; Zhang, Z.-W.; Kwong, F. Y. Atropisomeric Phosphine Ligands Bearing C–N axial Chirality: Applications in Enantioselective Suzuki-Miyaura Cross-Coupling Towards the Assembly of Tetra-ortho-Substituted Biaryls.  J. Am. Chem. Soc. 2022, 144, 14864.  (Spotlights on JACS publication, J. Am. Chem. Soc. 2022, 144, 14403).

3，Tse, M. H.; Zhong, R.-L.; Kwong, F. Y.  Palladium-Catalyzed Miyaura Borylation of Overly Crowded Aryl Chlorides Enabled by a Complementary Localized/Remote Steric Bulk of Ligand Chassis.  ACS Catal. 2022, 12, 3507.