王志仁 教授

电子邮箱： zhirenwang@scut.edu.cn

     教育与工作经历

2024-至今，华南理工大学生物医学科学与工程学院，教授

2019-2024，美国亚利桑那大学药学院，博士后

2017-2018，中山大学，特聘副研究员

2016-2016，美国加州大学San Diego分校，博士后

2011-2016，中山大学药学院，博士

脂质体药物、药物递送、肿瘤免疫治疗

主讲课程

Fundamentals of Chemistry II—Organic Chemistry Ⅱ

研究成果

基于药物化学、药物递送及纳米医学，致力于新型磷脂及其前药分子技术的开发、构建脂质体药物制剂平台用于药物递送、肿瘤免疫治疗以及神经退行性疾病创新疗法等方面。以第一或通讯作者在Nature Nanotechnology、Nature Cancer、Nature Communications、Biomaterials、Journal of Controlled Release、Journal of Medicinal Chemistry等学术期刊发表20余篇研究论文，申请新型药物分子发明专利5项，授权3项，主持国家自然科学基金优秀青年科学基金项目（海外）、面上、青年及省部级项目。

代表性论文：

1. Zhiren Wang, Wenpan Li,Yanhao Jiang, Teng Ma, Mengwen Li, et al. Asphingolipid-derived Paclitaxel nanovesicle enhances efficacy of combinationtherapies in triple negative breast cancer and pancreatic cancer. NatureCancer2025, 6,1734-1753.

2. Zhiren Wang, Jianqin Lu. Asphingolipid-derived paclitaxel nanovesicle for improved cancer therapy.Nature Cancer 2025, 6, 1619-1620.

3. Zhiren Wang, Nicholas Little, JiaweiChen, Kevin Tyler Lambesis, Kimberly Thi Le, et al. Immunogenic camptothesome nanovesiclescomprised by sphingomyelin-derived camptothecin bilayers for safe and synergisticcancer immunochemotherapy. Nature Nanotechnology 2021,16, 1130-1140.

4. Zhiren Wang, Wenpan Li, Yanhao Jiang,Tuyen Ba Tran, Leyla Estrella Cordova, et al. Sphingomyelin-derivednanovesicles for the delivery of the IDO1 inhibitor epacadostat enhancemetastatic and post-surgical melanoma immunotherapy. Nature Communications, 2023, 14, 7235.

5. Zhiren Wang, Wenpan Li, Jonghan Park,Karina Marie Gonzalez, Xiangmeng Wu, et al. Cholesterol-modified sphingomyelin chimericlipid bilayer for fortified therapeutic delivery. NatureCommunications, 2024, 15, 2073.

6. Zhiren Wang, Wenpan Li, Yanhao Jiang,Tuyen Ba Tran, Jinha Chung, et al. Camptothesome-based combinationnanotherapeutic regimen for improved colorectal cancer immunochemotherapy.Biomaterials, 2024, 306, 122477.

7. Zhiren Wang, Wenpan Li, Jonghan Park,Karina Marie Gonzalez, Aaron James Scott, et al. Camptothesomeelicits immunogenic cell death to boost colorectal cancer immune checkpoint blockade.Journal of Controlled Release, 2022,349, 929-939.

8. Zhiren Wang, Jiawei Chen, Nicholas Little, JianqinLu. Self-assembling prodrug nanotherapeutics for synergistic tumor targeteddrug delivery. Acta Biomaterialia 2020, 111, 20-28.

9. Zhiren Wang, Jinhui Hu, Xiaoping Yang,Xing Feng, Xingshu Li, et al. Design, synthesis, and evaluation of orally bioavailablequinoline–indole derivatives as innovative multitarget-directed ligands: promotionof cell proliferation in the adult murine hippocampus for the treatment ofAlzheimer’s disease. Journal of Medicinal Chemistry 2018, 61, 1871-1894.

10. Zhiren Wang, Yali Wang, Bo Wang, WenruiLi, Ling Huang, et al. Design, synthesis and evaluation oforally available clioquinol-moracin M hybrids as multi-target-directed ligandsfor cognitive improvement in a rat model of neurodegeneration in Alzheimer’s disease.Journal of Medicinal Chemistry 2015, 58, 8616-8637.