报告题目：Next-Generation Antimicrobial Materials: Photodynamic, Anionic, and Hybrid Strategies for Infection Prevention

报 告 人：REZA A. GHILADI 教授

报告时间：2026年11月16日  星期一下午15:00~16:30

报告地点：国际校区C2-a201会议室

主办单位：：材料科学与工程学院

报告人简介：

Reza A. Ghiladi 教授现任北卡罗来纳州立大学化学系教授、系主任（2024-至今），同时担任理学院教师咨询委员会主席及终身教职与晋升委员会委员。他1995年本科毕业于 Haverford 学院，2001年获 JohnsHopkins 大学博士学位，2001–2006年先后在 MayoClinic 与加州大学旧金山分校（UCSF）从事化学生物学博士后研究，2006年加入北卡州立大学化学系，历任助理教授、副教授至教授。其研究聚焦多功能血红素蛋白的作用机制、生物催化与酶工程、以及光动力抗菌材料（用于医院感染控制）三大方向。迄今主持 NSF、ARO、ACS 等机构资助项目，累计经费超360万美元；发表学术论文115+篇，H指数45，总引用5300+次；受邀作会议报告与讲座240余场。曾获 NSF CAREER Award（2012）、北卡州立大学杰出教学奖（2016）及理学院卓越教学奖（2013）。

报告摘要：

Hospital-acquired infections and the rapid rise of antibiotic-resistant pathogens present a critical global public health crisis. Because contaminated high-touch surfaces act as key vectors for disease transmission, developing self-sterilizing materials capable of continuous, broad-spectrum pathogen inactivation is essential. Here, three material platforms engineered to prevent microbial transmission across diverse settings without inducing drug resistance will be presented: I) Antimicrobial Photodynamic Inactivation (aPDI), which utilizes non-toxic photosensitizers, visible light, and ambient molecular oxygen to generate microbicidal reactive oxygen species (ROS), predominantly singlet oxygen, 1O2, will be presented. When conjugated or embedded into functional scaffolds spanning nanocellulose, electrospun nanofibers (nylon, polyacrylonitrile, cellulose diacetate), and photo-crosslinkable spray coatings (SbQ-PVA), these aPDI materials achieve high-levels of inactivation against Gram-positive and Gram-negative bacteria, viruses, and fungi. Innovative formulations, including dual-dyed blended fabrics, maintain high antimicrobial performance while affording a broad color expression suitable for commercial personal protective equipment. II) Antimicrobial Anionic Inactivation (aAI), as a complement to photo-activated systems, is introduced as a rapid, light-independent alternative wherein charged multiblock polymers create a dramatic surface pH drop upon hydration, achieving multi-log pathogen reduction in minutes. III) Synergistic Hybrid Systems combining aPDI with photothermal agents (e.g., MoS2) or long-persistent phosphors (SAOED) demonstrate how multi-mechanistic approaches can overcome Gram-negative outer membrane permeability barriers and enable sustained antimicrobial activity even in the dark. Together, these materials represent a paradigm shift in self-disinfecting surfaces to combat surface-mediated pathogen transmission.