报告题目：Microphysiological Systems for Emulating Human Tissues and Diseases

　　报告人：张宇（Y. Shrike Zhang）博士，哈佛大学医学院（Harvard Medical School）

　　报告时间：2018年8月30日上午9:00

　　报告地点：制浆造纸工程国家重点实验室306会议室

　　欢迎广大师生前往!

                                                                             轻工科学与工程学院

                                                                        制浆造纸工程国家重点实验室

                                                                               2018年8月21日

　　报告内容：

　　Microphysiological systems are microfluidic three-dimensional miniature human tissue and organ models that recapitulate the important biological and physiological parameters of theirin vivo counterparts. They have recently emerged as a viable platform for personalized medicine and drug screening. These biomimetic organoids are anticipated to replace the conventional planar, static cell cultures, and to bridge the gaps between the current pre-clinical animal models and the human body. In addition, multiple organoids may be channeled together through the microfluidics in a similar manner they arrange invivo, providing the capacity to analyze interactions among these models. In this talk, I will discuss our recent efforts on developing integrated multi-organ-on-a-chip platforms formed by sophisticated microfluidics and bioengineered organoids, which can operate in a continual and automated manner over extended periods. I will also discuss a series of bioprinting strategies including sacrificial bioprinting, microfluidic bioprinting, and multi-material bioprinting, along with various cytocompatible bioink formulations, for the fabrication of biomimetic organoids. These platform technologies will likely provide new opportunities in constructing functional tissue and disease models with a potential extension into clinical therapeutics and precision therapy.

　　报告人简介：

　　Dr. Zhang received a B.Eng. in Biomedical Engineering from Southeast University, China in 2008, after which he then obtained a M.S. in Biomedical Engineering from Washington University in St. Louis (2011) and a Ph.D. in Biomedical Engineering at Georgia Institute of Technology and Emory University School of Medicine (2013). Dr. Zhang then pursued postdoctoral training at Brigham and Women’s Hospital, Harvard Medical School, Harvard-MIT Division of Health Sciences and Technologies, and Wyss Institute for Biologically Inspired Engineering. (www.shrikezhang.com)

　　Dr. Zhang is currently a Research Faculty at Harvard Medical School and Associate Bioengineer at the Brigham and Women’s Hospital. His research is focused on innovating medical engineering technologies, including 3D bioprinting, organs-on-chips, microfluidics, biomedical imaging, and biosensing, to recreate functional tissues and their biomimetic models. In collaboration with a multidisciplinary team encompassing biomedical, mechanical, electrical, and computer engineers as well as biologists and clinicians, his laboratory seeks to ultimately translate these cutting-edge technologies into the clinics. He is an author of >120 publications and his scientific contributions have been recognized by >40 international, national, and regional awards. More information can be found on his website.