报告题目：Bioinspired materials for intervertebral disc regeneration

报 告 人：Catherine Le Visage（教授 法国南特大学）

主 持 人：王均教授

报告时间：2025年10月21日（星期二）9:30-12:00

报告地点：华南理工大学广州国际校区C1b-115

主办单位：生物医学科学与工程学院

 生物医学科学与工程学院

                                        2025年10月14日

报告人简介：

Dr. Catherine Le Visage trained as a Pharmacist, received her Ph.D. in Pharmaceutical Sciences, and then performed a post-doc at the Johns Hopkins University (USA). She then joined the French National Institute of Health and Medical Research in a tenured position. Her most recent works as a group leader have focused on innovative hydrogels as i) carriers of cells or bioactive molecules in the context of intervertebral disc disease and osteoarthritis and ii) biofabrication tools for developing advanced in vitro models.

Dr. Catherine Le Visage is Chair-Elect of TERMIS-EU, an International Fellow of Tissue Engineering and Regenerative Medicine (FTERM) and a member of the French Academy of Pharmacy. She is an Associate Editor for Biomaterials (Elsevier).

报告摘要：

Intervertebral disc degeneration is a leading cause of chronic low back pain, imposing significant socioeconomic and healthcare burdens worldwide. Conventional clinical interventions, such as spinal fusion and artificial disc replacement, are often associated with long-term complications and fail to replicate the complex structural, mechanical, and biological functions of the native disc. Recent advances in biomaterials science offer a promising avenue for regenerative therapies that aim to restore disc function through bioinspired design principles.

This talk will explore the development of next-generation biomaterials engineered to mimic the hierarchical architecture and multifunctionality of the native IVD. Emphasis will be placed on the integration of tissue-specific mechanical properties, anisotropic load-bearing capabilities, and cellular microenvironments conducive to disc regeneration. We will examine current strategies in scaffold design, including composite hydrogels, electrospun fibrous networks, and 3D-bioprinted constructs.  Additionally, the talk will highlight incorporating bioactive components, such as GDF-5 or TGF-beta growth factors, extracellular vesicles, and adult stem cells, into scaffold designs to enhance regenerative outcomes and restore disc functionality. Through an interdisciplinary lens, this talk will highlight the translational potential of bioinspired materials and the challenges that remain in their clinical application.