报告题目：Engineering Biomaterials for Regenerative Medicine

报 告 人：Huinan Hannah Liu（加州大学教授）

主 持 人：边黎明教授

报告时间：2024年12月17日（星期二）上午10:00-11:30

报告地点：华南理工大学广州国际校区C1b-114

主办单位：生物医学科学与工程学院

                                        2024年12月12日

报告人简介：

Dr. Huinan H. Liu currently is a Professor and Associate Dean of the Bourns College of Engineering at the University of California at Riverside (UCR). She is a Professor of Bioengineering, the Materials Science and Engineering Program, the Stem Cell Center, the Microbiology Program, the Cellular, Molecular, and Developmental Biology (CMDB) Program, and the Biomedical Sciences Program of the UCR School of Medicine.Dr. Huinan H. Liu currently is a Professor and Associate Dean of the Bourns College of Engineering at the University of California at Riverside (UCR). She is a Professor of Bioengineering, the Materials Science and Engineering Program, the Stem Cell Center, the Microbiology Program, the Cellular, Molecular, and Developmental Biology (CMDB) Program, and the Biomedical Sciences Program of the UCR School of Medicine. She received her Ph.D. in Biomedical Engineering from Brown University in 2008 and her M.S. and B.S. in Materials Science and Engineering from Purdue University and the University of Science and Technology in Beijing. Her research focuses on engineering novel biodegradable materials and nanostructured interfaces for controlling cellular functions toward improving tissue regeneration and reducing infections. Major innovations from her research group involved design, fabrication, and characterization of new bioresorbable alloys as the next-generation implant materials, new surface modification strategies to regulate their degradation rate for the implants to meet clinical needs, new nanocomposites for guided tissue repair, and elucidation of the interactions of new biomaterials with relevant cells and bacteria for potential clinical translation. She has supervised 35 graduate students and 164 undergraduate researchers since she established her lab at UCR in 2011. Her work has led to >120 refereed journal articles, 30 conference proceeding papers, 4 books, 16 invited book chapters, 2 issued patents, >80 invited talks, and >160 conference presentations and abstracts.

报告摘要：

Engineered bioresorbable materials provide promising solutions for tissue engineering and regenerative medicine. Bioresorbable implants and devices are designed to degrade harmlessly in the body over time as new tissues grow, which eliminates the need for secondary surgeries and associated complications. Recent researches on biodegradable polymers and metals have demonstrated their potentials for clinical translations, but there are still major challenges yet to be addressed, e.g. (1) controlling their degradation rates with tissue healing rates, and (2) modulating their bioactivities to promote healing functions of desirable cells while inhibiting bacterial infections. In this presentation, our recent progress on developing bioresorbable alloys and nanostructured composites as the next-generation biomaterials, and creating new surface modification strategies and biodegradable composites to regulate their degradation rates, will be discussed. Degradation of bioalloys and composites and their in vitro cytocompatibility with relevant host cells, and functional evaluation in animal models in vivo will be presented.