蒋兴垭 教授（PI）
国家级青年人才项目入选者
办公地址：广州国际校区C1-b313
电子邮件:xingyajiang@scut.edu.cn
蒋兴垭 教授（PI）
国家级青年人才项目入选者
2021 — 至今 华南理工大学生物医学科学与工程学院 教授
2019 — 2021 美国哈佛大学医学院 博士后
2014 — 2019 美国德克萨斯大学达拉斯分校 博士
2010 — 2014 北京理工大学 学士
生物医学工程（学博、学硕）、材料与化工（工程博士）、生物学（学博、学硕）、生物与医药（工程硕博）
纳米生物效应、纳米生理学、分子/纳米探针、RNA药物
主要运用分析化学、分子生物学和生物成像等手段研究纳米粒子与活体的界面相互作用机制，主要关注纳米粒子与肝脏、肾脏和肿瘤等器官和组织的相互作用及其体内转运和代谢清除过程，以促进对纳米材料与体内复杂生理环境相互作用的认知，并基于此进一步设计和开发新型纳米药物用于相关疾病诊疗。课题组主要开展体内纳米生物学效应、疾病诊断探针和肝肾脏靶向药物/基因递送等领域研究，研究成果以第一/通讯作者发表于NatureNanotechnology、Science Advances、Nature Communications、Angew. Chem. Int. Ed.、ACSNano、Nano Letters 等国际知名学术期刊。发表英文专著2章，授权国内外发明专利7项，主持/参与国家级青年人才项目、国自然面上项目、国家重点研发计划青年项目、广州市基础与应用基础研究项目等。
1. Yunfeng Ren, Fang Mei, Huixu Lu, Yazhe Liang, Rui Zheng, Ziyuan Wang,Fengying Liang, Bujie Du*, Xingya Jiang* “Priming the Liver Endocytic Pathwayto Accelerate Hepatobiliary Clearance of Nanoparticles” ACS Nano, 2026,DOI: 10.1021/acsnano.5c20532
2. Yazhe Liang, Huixu Lu, JunyangZhong, Xiang Li, Rui Zheng, Bujie Du*, Xingya Jiang*. Alloying impacts in vivo behaviors of ultrasmall noble-metalnanoparticles through intermetallic charge-transfer mediated ligand-coreinteractions Nano Letters, 2026, 26(3),1135
3.Jieman Liu, Xiang Li, Huixu Lu, Fengying Liang,Yiqiao Chen, Yexi Peng, Bujie Du*, Xingya Jiang*. Charge-Pairing EnabledRenal-Clearable Chemiluminescent Gold Nanoprobes for Ratiometric Imaging andUrinalysis of Pathological Reactive Oxygen Species ACS Nano, 2025,19, 39, 34772–34784
4. Mingze Xu, Yuming Qi, Yexi Peng, Huixu Lu, Yiqiao Chen, Ziyuan Wang,Yuming Lin, Xingya Jiang*, Bujie Du*.Reno-protective CT ContrastNanoagent Targets Proximal Tubular Epithelium for Kidney Disease Imaging andRepair in a Mouse Model Nature Communications, 2025, 16, 9346
5.Lu, Huixu; Ren, Yunfeng; Qi, Yuming; Xu, Mingze; Liang,Fengying; Wang, Ziyuan; Liu, Jieman; Du, Bujie*; Jiang,Xingya*.Overcoming Hepatic Biotransformation Barrier of GoldNanoparticles via Au-Se Bond for Enhanced In-Vivo Active Targeting ACSNano, 2024, 18, 42, 29178–29188
6.Qi, Yuming, Mingze Xu, Huixu Lu, Xiaoxian Wang, YexiPeng, Ziyuan Wang, Fengying Liang, Xingya Jiang,* and Bujie Du*. HepaticBiotransformation of Renal Clearable Gold Nanoparticles for NoninvasiveDetection of Liver Glutathione Level via Urinalysis. AngewandteChemie International Edition, 2024,63, e202409477.
7.Xu, Mingze, Yuming Qi, Gaoshuo Liu, Yuanqing Song,Xingya Jiang*, and Bujie Du*. Size-Dependent In Vivo Transport ofNanoparticles: Implications for Delivery, Targeting, and Clearance. ACSNano, 2023, 17(21). 20825-20849.
8.Xingya Jiang#; Qinhan Zhou#; Bujie Du; Siqing Li; Yingyu Huang;Zhikai Chi; William M. Lee; Mengxiao Yu; Jie Zheng*; Noninvasive Monitoring of HepaticGlutathione Depletion Through Fluorescence Imaging and Blood Testing, ScienceAdvances, 2021, 7(8): eabd9847.
9. Xingya Jiang; Bujie Du; Shaoheng Tang; Jer-Tsong Hsieh; Jie Zheng*;Photoacoustic Imaging of Nanoparticle Transport in the Kidneys at High TemporalResolution, Angewandte Chemie International Edition, 2019,58(18):5994-6000.
10. Xingya Jiang; Bujie Du; Jie Zheng*; Glutathione-mediated Biotransformationin the Liver Modulates Nanoparticle Transport, Nature Nanotechnology,2019, 14(9): 874-882.
实验室网页:https://www.x-mol.com/groups/ultranano
英才专访
蒋兴垭：科研需要不断地尝试与坚持，才能体会到它带来的成就与快乐