王真真 教授（PI）

国家级青年人才项目入选者

华南理工大学TCL青年学者

电子邮件:zwang@scut.edu.cn

办公地址：广州国际校区C1-b312

2023-至今，华南理工大学生物医学科学与工程学院 教授

2020-2023，美国北卡罗来纳州立大学 博士后

2018-2020，美国国立环境健康科学研究所 博士后

2012-2018，中国科学院大学长春应用化学研究所 无机化学 博士

生物医学工程（学博、学硕）、生物学（学博、学硕）、材料与化工（工程博士）、生物与医药（工程硕博）

生物活性材料、再生医学、纳米医学、药物递送载体

长期聚焦于生物活性材料与再生医学的交叉前沿，尤以工程化外泌体及细胞膜仿生纳米系统为核心工具，致力于攻克肺部重症疾病与恶性肿瘤治疗中的关键科学瓶颈。近年来在Nature Biomedical Engineering, Nature Nanotechnology, Science Advances, Nature Communications、Nature Biotechnology等国际高质量期刊发表论文50余篇，引用次数超8000余次，H-index为38，主持海外高层次引进人才项目。担任Biomimetics及Frontiers in Bioengineering and Biotechnology客座编辑。

代表性论文：

1. Zhenzhen Wang, Kristen D. Popowski, Dashuai Zhu, Blanca López de Juan Abad, Xianyun Wang, Mengrui Liu, Halle Lutz, Nicole De Naeyer, C. Todd DeMarco, Thomas N. Denny, Phuong-Uyen C. Dinh, Zhenhua Li, Ke Cheng, Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine. Nature Biomedical Engineering, 2022, 6 (7), 791-805 (封面文章). 

2. Zhenzhen Wang*, Shiqi Hu, Kristen D. Popowski, Shuo Liu, Dashuai Zhu, Xuan Mei, Junlang Li, Yilan Hu, Phuong-Uyen C. Dinh, Xiaojie Wang, Ke Cheng, Inhalation of ACE2-expressing lung exosomes provides prophylactic protection against SARS-CoV-2. Nature Communications, 2024, 15, 942-951.

3. Zhenzhen Wang, Zhenhua Li, Weiwei Shi, Dashuai Zhu, Shiqi Hu, Phuong-Uyen C. Dinh, Ke Cheng, A SARS-CoV-2 and influenza double hit vaccine based on RBD-conjugated inactivated influenza A virus. Science Advances, 2023, 9 (25), eabo4100.

4. Zhenhua Li#, Zhenzhen Wang#, Phuong-Uyen C. Dinh, Dashuai Zhu, Kristen D. Popowski, Halle Lutz, Shiqi Hu, Mark G. Lewis, Anthony Cook, Hanne Andersen, Jack Greenhouse, Laurent Pessaint, Leonard J. Lobo, Ke Cheng, Cell-mimicking nanodecoys neutralize SARS-CoV-2 and mitigate lung injury in a non-human primate model of COVID-19. Nature Nanotechnology, 2021, 16, 942-951.

5. Shuo Liu#, Mengrui Liu#, Zhenzhen Wang#, Shiqi Hu, Kaiyue Zhang, Chao Lu, Xiao Cheng, Ming Shen, Jianning Bi, Dashuai Zhu, Ke Cheng, Engineering bispecific exosome activators of T cells to target immune checkpoint inhibitor-resistant metastatic melanoma. Nature Biotechnology, 2026, DOI: 10.1038/s41587-025-02890-8.

6. Zhenzhen Wang, Yan Zhang, Enguo Ju, Zhen Liu, Fangfang Cao, Zhaowei Chen, Jinsong Ren, Xiaogang Qu, Biomimetic Nanoflowers by Self-Assembly of Nanozymes to Induce Intracellular Oxidative Damage Against Hypoxic Tumors. Nature Communications, 2018, 9, 3334.

7. Zhaowei Chen#, Zhenzhen Wang#; Jinsong Ren, Xiaogang Qu, Enzyme Mimicry for Combating Bacteria and Biofilms. Acc Chem Res, 2018, 51, 789-799.

8. Zhenzhen Wang, Nikolaus Jork, Tamara Bittner, Huanchen Wang, Henning J Jessen, Stephen B Shears, Rapid stimulation of cellular Pi uptake by the inositol pyrophosphate InsP8 induced by its photothermal release from lipid nanocarriers using a near infra-red light-emitting diode. Chemical. Science. 2020, 11, 10265.

9. Zhenzhen Wang, Kai Dong, Zhen Liu, Yan Zhang, Zhaowei Chen, Hanjun Sun, Jinsong Ren, Xiaogang Qu, Activation of Biologically Relevant Levels of Reactive Oxygen Species by Au/g-C3N4 Hybrid Nanozyme for Bacteria Killing and Wound Disinfection. Biomaterials, 2017, 113, 145-157.

10. Zhenzhen Wang, Zhaowei Chen, Zhen Liu, Peng Shi, Kai Dong, Enguo Ju, Jinsong Ren, Xiaogang Qu, A Multi-Stimuli Responsive Gold Nanocage-Hyaluronic Platform for Targeted Photothermal and Chemotherapy. Biomaterials, 2014, 35, 9678-9688.