
王志仁 教授
国家级青年人才项目入选者
办公地址:广州国际校区C1-b410
王志仁 教授
国家级青年人才项目入选者
办公地址:广州国际校区C1-b410
2024-至今 华南理工大学生物医学科学与工程学院 教授
2019-2024 美国亚利桑那大学药学院 博士后
2017-2018 中山大学 特聘副研究员
2016-2016 美国加州大学San Diego分校 博士后
2011-2016 中山大学药学院 博士
生物医学工程(学博、学硕)、生物学(学博、学硕)、材料与化工(工程博士)、生物与医药(工程博士)
药物制剂、药物递送、肿瘤免疫治疗
主要从事新型磷脂及其前药分子技术的开发、构建脂质体药物制剂平台及其在药物递送、肿瘤免疫治疗以及神经退行性疾病创新疗法等方面的研究。在Nature Nanotechnology、Nature Cancer、Nature Communications、Biomaterials、Journal of Controlled Release、Journal of Medicinal Chemistry等学术期刊发表20余篇研究论文,申请新型药物分子发明专利5项,授权3项,主持国家海外高层次引进人才青年项目。
代表性论文列表:
1. Zhiren Wang, Wenpan Li, Yanhao Jiang, Teng Ma, Mengwen Li, et al. A sphingolipid-derived Paclitaxel nanovesicle enhances efficacy of combination therapies in triple negative breast cancer and pancreatic cancer. Nature Cancer 2025, in press.
2. Zhiren Wang, Jianqin Lu. A sphingolipid-derived paclitaxel nanovesicle for improved cancer therapy. Nature Cancer 2025, in press.
3. Zhiren Wang, Nicholas Little, Jiawei Chen, Kevin Tyler Lambesis, Kimberly Thi Le, et al. Immunogenic camptothesome nanovesicles comprised by sphingomyelin-derived camptothecin bilayers for safe and synergistic cancer immunochemotherapy. Nature Nanotechnology 2021, 16, 1130-1140.
4. Zhiren Wang, Wenpan Li, Yanhao Jiang, Tuyen Ba Tran, Leyla Estrella Cordova, et al. Sphingomyelin-derived nanovesicles for the delivery of the IDO1 inhibitor epacadostat enhance metastatic and post-surgical melanoma immunotherapy. Nature Communications, 2023, 14, 7235.
5. Zhiren Wang, Wenpan Li, Jonghan Park, Karina Marie Gonzalez, Xiangmeng Wu, et al. Cholesterol-modified sphingomyelin chimeric lipid bilayer for fortified therapeutic delivery. Nature Communications, 2024, 15, 2073.
6. Zhiren Wang, Wenpan Li, Yanhao Jiang, Tuyen Ba Tran, Jinha Chung, et al. Camptothesome-based combination nanotherapeutic regimen for improved colorectal cancer immunochemotherapy. Biomaterials, 2024, 306, 122477.
7. Zhiren Wang, Wenpan Li, Jonghan Park, Karina Marie Gonzalez, Aaron James Scott, et al. Camptothesome elicits immunogenic cell death to boost colorectal cancer immune checkpoint blockade. Journal of Controlled Release, 2022, 349, 929-939.
8. Zhiren Wang, Jiawei Chen, Nicholas Little, Jianqin Lu. Self-assembling prodrug nanotherapeutics for synergistic tumor targeted drug delivery. Acta Biomaterialia 2020, 111, 20-28.
9. Zhiren Wang, Karina Marie Gonzalez, Leyla Estrella Cordova, Jianqin Lu. Nanotechnology-empowered therapeutics targeting neurodegenerative diseases. WIREs Nanomedicine & Nanobiotechnology 2023, 15, e1907.
10. Zhiren Wang, Jinhui Hu, Xiaoping Yang, Xing Feng, Xingshu Li, et al. Design, synthesis, and evaluation of orally bioavailable quinoline–indole derivatives as innovative multitarget-directed ligands: promotion of cell proliferation in the adult murine hippocampus for the treatment of Alzheimer’s disease. Journal of Medicinal Chemistry 2018, 61, 1871-1894.
11. Zhiren Wang, Yali Wang, Bo Wang, Wenrui Li, Ling Huang, et al. Design, synthesis and evaluation of orally available clioquinol-moracin M hybrids as multi-target-directed ligands for cognitive improvement in a rat model of neurodegeneration in Alzheimer’s disease. Journal of Medicinal Chemistry 2015, 58, 8616-8637.