王真真 教授（PI）

国家级青年人才项目入选者

电子邮件:zwang@scut.edu.cn

办公地址：广州国际校区C1-b312

2023-至今，华南理工大学生物医学科学与工程学院 教授

2020-2023，美国北卡罗来纳州立大学 博士后

2018-2020，美国国立环境健康科学研究所 博士后

2012-2018，中国科学院大学长春应用化学研究所 无机化学 博士

生物医学工程（学博、学硕）、生物学（学博、学硕）、材料与化工（工程博士）、药学（专硕）

细胞外囊泡、生物医学材料、再生医学

从事工程化外泌体疫苗的研发以及细胞外囊泡在肺部疾病的再生医学。近年来，以第一作者在Nature Biomedical Engineering, Nature Nanotechnology, ScienceAdvances, Nature Communications等国际高质量期刊发表论文10篇，引用次数超4000余次，H-index为28，主持海外高层次引进人才项目。担任Biomimetics及Frontiers in Bioengineering and Biotechnology客座编辑。

代表性论文：

1.Zhenzhen Wang, Kristen D. Popowski, Dashuai Zhu, Blanca López de Juan Abad, Xianyun Wang, Mengrui Liu, Halle Lutz, Nicole De Naeyer, C. Todd DeMarco, Thomas N. Denny, Phuong-Uyen C. Dinh, Zhenhua Li, Ke Cheng, Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine. Nature Biomedical Engineering, 2022, 6 (7), 791-805 (封面文章).

2.Zhenzhen Wang, Yan Zhang, Enguo Ju, ZhenLiu, Fangfang Cao, Zhaowei Chen,Jinsong Ren, Xiaogang Qu, Biomimetic Nanoflowers bySelf-Assembly of Nanozymes to Induce Intracellular Oxidative Damage AgainstHypoxic Tumors. Nature Communications, 2018, 9, 3334.

3.Zhenzhen Wang, Zhenhua Li, Weiwei Shi, Dashuai Zhu,Shiqi Hu, Phuong-Uyen C. Dinh, Ke Cheng, ASARS-CoV-2 and influenza double hit vaccine based on RBD-conjugated inactivatedinfluenza A virus. Science Advances (June, 2023)

4.Zhenhua Li#, Zhenzhen Wang#, Phuong-Uyen C. Dinh, DashuaiZhu, Kristen D. Popowski, Halle Lutz, Shiqi Hu, Mark G. Lewis, Anthony Cook,Hanne Andersen, Jack Greenhouse, Laurent Pessaint, Leonard J. Lobo, Ke Cheng,Cell-mimicking nanodecoys neutralize SARS-CoV-2 and mitigate lung injury ina non-human primate model of COVID-19. Nature Nanotechnology, 2021, 16,942-951.

5.Zhaowei Chen#, Zhenzhen Wang#; Jinsong Ren, XiaogangQu, Enzyme Mimicry for Combating Bacteria and Biofilms. Acc Chem Res, 2018, 51,789-799.

6.Zhenzhen Wang, Nikolaus Jork, Tamara Bittner,Huanchen Wang, Henning J Jessen, Stephen B Shears, Rapid stimulation of cellular Pi uptake by the inositol pyrophosphateInsP8 induced by its photothermal release from lipid nanocarriers using a nearinfra-red light-emitting diode. Chemical. Science. 2020, 11, 10265.

7.Zhenzhen Wang, Kai Dong, Zhen Liu, Yan Zhang, ZhaoweiChen, Hanjun Sun, Jinsong Ren, Xiaogang Qu, Activation of Biologically RelevantLevels of Reactive Oxygen Species by Au/g-C3N4 HybridNanozyme for Bacteria Killing and Wound Disinfection. Biomaterials, 2017, 113,145-157.

8.Zhenzhen Wang, Zhaowei Chen, Zhen Liu, Peng Shi, KaiDong, Enguo Ju, Jinsong Ren, Xiaogang Qu, A Multi-Stimuli Responsive GoldNanocage-Hyaluronic Platform for Targeted Photothermal and Chemotherapy. Biomaterials,2014, 35, 9678-9688.