2023—至今 华南理工大学生物医学科学与工程学院 教授
2019—2023 香港中文大学 博士后
2015—2019 香港中文大学生物医学工程系 博士
2011—2015 山东大学 学士生物医学工程（学博、学硕）、生物学（学博、学硕）、材料与化工（工程博士）、生物与医药（工程硕博）
研究围绕液-液相分离凝聚体生物材料与重大疾病治疗的交叉领域开展。主要研究方向包括：
（1）凝聚体（Coacervates）生物材料设计与组装机制：发展了多种多价弱相互作用驱动的生理稳定型凝聚体，从材料设计层面推动凝聚体由易解离的体外科学模型转变为可在复杂体内环境中使用的工程化生物材料。
（2）凝聚体及凝聚体衍生材料（如水凝胶）在无膜细胞器/细胞/组织仿生构建、药物递送、疾病免疫治疗、组织工程与再生医学等交叉领域的应用。
液-液相分离是生命体系实现分子组织、反应区室化、细胞功能调控及组织异质结构形成的重要基本机制。围绕“如何将生命体系中普遍存在但难以工程化利用的液-液相分离凝聚体，通过高分子化学、材料科学或合成生物学等手段，转化为可设计、结构稳定、具有独特生物医学功能的新型液体生物材料”的关键科学问题，在Nat. Biomed. Eng.、Nat. Chem.、Nat. Rev. Mater.、Natl. Sci. Rev.、Sci. Adv.、Nat. Commun.、J.Am. Chem. Soc.、Angew. Chem. Int. Ed.、Adv. Mater. 等期刊以通讯作者或第一作者发表论文20余篇。主持国家自然科学基金优青（海外）、国家重点研发计划课题、国家自然科学基金面上等多项国家及省部级项目。
欢迎感兴趣的本科生、研究生和博士后加入。研究背景包括但不限于生物医学工程、高分子化学/材料学、化学、生命科学、合成生物学、生物三维打印、人工智能与材料设计、临床医学等。
研究团队网站：https://www.x-mol.com/groups/bian_lab/people
代表性论文
1. Sirong Chen, *Pengchao Zhao, *Liming Bian, et al. Cartilage-binding coacervate with therapeutic payload delivery and biomimetic lubrication alleviates osteoarthritis by reducing joint friction and inflammation. Nature Biomedical Engineering, 2026, Accepted.
2. Bo Yi, *Kunyu Zhang, *Pengchao Zhao, *Liming Bian, et al. Superspreadingand ultra-infiltrative coacervate mediates strong underwater adhesion on hydrated and lipidic substrates. Nature Chemistry, 2026, 18, 790–799.
3. Bo Yi, *Yan Qiao, *Pengchao Zhao, *Liming Bian, et al. Engineered coacervates as emerging liquid biomaterials. Nature Reviews Materials,2026, https://doi.org/10.1038/s41578-026-00950-2.
4. Xian Xie, *Yi Wang, *Pengchao Zhao, *Liming Bian, et al. A designer minimalistic model parallels the phase separation-mediated assembly and biophysical cues of extracellular matrix. Nature Chemistry, 2025, 17, 1216.
5. Fengming Tan, *XiayiXu, *Pengchao Zhao, *Liming Bian, et al. Muco-Infiltrating Prodrug Coacervates with Prolonged Colonic Retention Enhance IBD-Associated Depression Therapy. National Science Review, 2026, nwag487.
6. Qian Chen, *PengchaoZhao, *Liming Bian, et al. Targeting Non-Classical Monocytes via Artificial Cell-Microneedles for Precision Psoriasis Therapy. Advanced Materials, 2026, e74726.
7. Jianyang Zhao, *XaixiXu, *Miao Cui, *Pengchao Zhao, *Liming Bian, et al. Tissue-conforming organoselenium hydrogel with microphase-controlled acylhydrazone crosslinking kinetics expedites diabetic wound healing by inhibiting AGE-RAGE pathways. Advanced Materials, 2026, e72776.
8. Ruinan Wang, *Xuefeng Yang, *Pengchao Zhao, *Liming Bian, et al. Enhanced biofilm infiltration by drug-laden coacervatefor treating refractory infections. Advanced Materials, 2026, e21500.
9. Qingqiao Xie, *Yong Li, *PengchaoZhao, *Liming Bian, et al. Fluidic microgel assemblies with enhanced oral delivery of biologics alleviate colonic inflammation in murine and canine models. Science Advances, 2025, eadv6994.
10. Tianshen Jiang, *Liming Bian, *Pengchao Zhao, *Fuxin Wei, et al. Superporoussponge prepared by secondary network compaction with enhanced permeability and mechanical properties for non-compressible hemostasis in pigs. Nature Communications, 2024, 15, 5460.
11. Xuefeng Yang, *Pengchao Zhao, *LimingBian,et al. Coacervation-mediated cytocompatible formation of supramolecular hydrogels with self-evolving macropores for 3D multicellular spheroid culture. Advanced Materials,2023, 202300636.
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