张琨雨    副教授（博导）

办公电话：020-81182184

电子邮件: kyuzhang@scut.edu.cn

办公地址：广州国际校区C1-b509

2021 — 至今 华南理工大学生物医学科学与工程学院 副教授

2019 — 2021 美国约翰霍普金斯大学  博士后

2018 — 2019  新加坡南洋理工大学  博士后

2014 — 2018  香港中文大学  博士

2010 — 2014  香港理工大学、中山大学  学士

生物医学工程（学博、学硕）、生物学（学博、学硕）、药学（专硕）、材料与化工（工程博士）

生物材料、力学生物学、细胞工程、再生医学

主要研究方向包括生物支架材料的设计及其在细胞工程、再生医学中的应用。重点关注动态微环境中生物化学及生物物理信号对细胞命运的影响，成功调控了不同细胞行为，从而满足不同细胞治疗的需求。共计发表学术论文30余篇，申请/授权国内外专利3项，其中第一或共同第一作者论文16篇，包括Chemical Reviews，Science Translational Medicine， Advanced Materials，Advanced Functional Materials，Advanced Science，Biomaterials，Small等领域内知名期刊。曾荣获中国生物材料大会青年学者奖、香港医疗保健器械业协会学生研究成就奖、美国生物材料年会STAR奖等国内外奖项与荣誉。

代表性论文

1. +Zhang, K.; +Feng, Q.; Fang, Z.; *Gu, L.; *Bian, L. “Structurally dynamic hydrogels for biomedical applications: pursuing a fine balance between macroscopic stability and microscopic dynamics”, Chemical Reviews, 2021.

2. +Xu, X.; +Xia, X.; +Zhang, K.; Rai, A.; Li, Z.; Zhao, P.; Wei, K.; Zou, L.; Yang, B.; Wong, W. K.; *Chiu, P. W. Y.; *Bian, L. “Bioadhesive hydrogels demonstrating pH-independent and ultrafast gelation promote gastric ulcer healing in pigs”, Science Translational Medicine, 2020, 12, eaba8014.

3. +Zhang, K.; +Chooi, W. H.; Liu, S.; Chin, J. S.; Murray, A.; Nizetic, D.; Cheng, D.; *Chew, S. Y. “Localized delivery of CRISPR/dCas9 via layer-by-layer self-assembling peptide coating on nanofibersfor neural tissue engineering”, Biomaterials, 2020, 120225.

4. +Zhang, K.; +Yuan, W.; Wei, K.; Yang, B.; Chen, X.; Li, Z.; *Zhang, Z.; *Bian, L. “Highly dynamic nanocomposite hydrogels self-assembled by metal ion-ligand coordination”, Small, 2019, 1900242.

5. +Kang, H.; +Zhang, K.; Jung, H. J.; Yang, B.; Chen, X.; Pan, Q.; Li, R.; Xu, X.; Li, G.; Dravid, V. P.; *Bian, L. “An in situ reversible heterodimeric nanoswitch controlled by metal ion-ligand coordination regulates the adhesion, release, and differentiation of stem cells”, Advanced Materials, 2018, 201803591.

6. +Zhang, K.; +Jia, Z.; Yang, B.; Feng, Q.; Xu, X.; Yuan, W.; Li, X.; Chen, X.; Duan, L.; *Wang, D.; *Bian, L. “Adaptable hydrogels mediate cofactor-assisted activation of biomarker-responsive drug delivery via positive feedback for enhanced tissue regeneration”, Advanced Science, 2018, 201800875.

7. +Kang, H.; +Zhang, K.; Pan, Q.; Lin, S.; Wong, D. S. H.; Li, J.; Lee, W. Y. W.; Yang, B.; Han, F.; Li, G.; *Li, B.; *Bian, L. “Remote control of intracellular calcium using upconversion nanotransducers regulates stem cell differentiation in vivo”, Advanced Functional Materials, 2018, 201802642.

8. +Kang, H.; +Zhang, K.; Wong, D. S. H.; Han, F.; *Li, B.; *Bian, L. “Near-infrared light-controlled regulation of intracellular calcium to modulate macrophage polarization”, Biomaterials, 2018, 178, 681.

9. Zhang, K.; Feng, Q.; Xu, J.; Xu, X.; Tian, F.; Yeung, K. W. K.; *Bian, L. “Self-assembled injectable nanocomposite hydrogels stabilized by bisphosphonate-magnesium (Mg²⁺) coordination regulates the differentiation of encapsulated stem cells via dual crosslinking”, Advanced Functional Materials, 2017, 1701642. 

10. +Zhang, K.; +Lin, S.; Feng, Q.; Dong, C.; Yang, Y.; *Li, G.; *Bian, L. “Nanocomposite hydrogels stabilized by self-assembled multivalent bisphosphonate-magnesium nanoparticles mediate sustained release of magnesium ion and promote in-situ bone regeneration”, Acta Biomaterialia, 2017, 64, 389. (Featured by Materials Today)

研究团队网站： https://www.x-mol.com/groups/bian_lab?lang=en

英才专访

星光领路人第5期|张琨雨：真正的研究，要么上书架，要么上货架