王志仁 教授

国家级青年人才项目入选者

电子邮件:zhirenwang@scut.edu.cn

办公地址：广州国际校区C1-b410

2024-至今 华南理工大学生物医学科学与工程学院 教授

2019-2024 美国亚利桑那大学药学院 博士后

2017-2018 中山大学 特聘副研究员

2016-2016 美国加州大学San Diego分校 博士后

2011-2016 中山大学药学院 博士

生物医学工程（学博、学硕）、生物学（学博、学硕）、材料与化工（工程博士）、生物与医药（工程博士）

药物制剂、药物递送、肿瘤免疫治疗

 主要从事新型磷脂及其前药分子技术的开发、构建脂质体药物制剂平台及其在药物递送、肿瘤免疫治疗以及神经退行性疾病创新疗法等方面的研究。在Nature  Nanotechnology、Nature Cancer、Nature Communications、Biomaterials、Journal  of Controlled Release、Journal of Medicinal Chemistry等学术期刊发表20余篇研究论文，申请新型药物分子发明专利5项，授权3项，主持国家海外高层次引进人才青年项目。

代表性论文列表：

1. Zhiren Wang, Wenpan  Li, Yanhao Jiang, Teng Ma, Mengwen Li, et al. A sphingolipid-derived  Paclitaxel nanovesicle enhances efficacy of combination therapies in  triple negative breast cancer and pancreatic cancer. Nature Cancer 2025,  in press.

2. Zhiren Wang, Jianqin  Lu. A sphingolipid-derived paclitaxel nanovesicle for improved cancer  therapy. Nature Cancer 2025, in press.

3. Zhiren Wang, Nicholas  Little, Jiawei Chen, Kevin Tyler Lambesis, Kimberly Thi Le, et al. Immunogenic  camptothesome nanovesicles comprised by sphingomyelin-derived camptothecin  bilayers for safe and synergistic cancer immunochemotherapy. Nature  Nanotechnology 2021, 16, 1130-1140.

4. Zhiren Wang, Wenpan  Li, Yanhao Jiang, Tuyen Ba Tran, Leyla Estrella Cordova, et al. Sphingomyelin-derived  nanovesicles for the delivery of the IDO1 inhibitor epacadostat enhance  metastatic and post-surgical melanoma immunotherapy. Nature Communications,  2023, 14, 7235.

5. Zhiren Wang, Wenpan  Li, Jonghan Park, Karina Marie Gonzalez, Xiangmeng Wu, et al. Cholesterol-modified  sphingomyelin chimeric lipid bilayer for fortified therapeutic delivery.  Nature Communications, 2024, 15, 2073.

6. Zhiren Wang, Wenpan  Li, Yanhao Jiang, Tuyen Ba Tran, Jinha Chung, et al. Camptothesome-based  combination nanotherapeutic regimen for improved colorectal cancer immunochemotherapy.  Biomaterials, 2024, 306, 122477.

7. Zhiren Wang, Wenpan  Li, Jonghan Park, Karina Marie Gonzalez, Aaron James Scott, et al. Camptothesome  elicits immunogenic cell death to boost colorectal cancer immune checkpoint  blockade. Journal of Controlled Release, 2022, 349, 929-939.

8. Zhiren Wang, Jiawei  Chen, Nicholas Little, Jianqin Lu. Self-assembling prodrug  nanotherapeutics for synergistic tumor targeted drug delivery. Acta  Biomaterialia 2020, 111, 20-28.

9. Zhiren Wang, Karina  Marie Gonzalez, Leyla Estrella Cordova, Jianqin Lu. Nanotechnology-empowered  therapeutics targeting neurodegenerative diseases. WIREs Nanomedicine & Nanobiotechnology 2023, 15, e1907.

10. Zhiren Wang, Jinhui  Hu, Xiaoping Yang, Xing Feng, Xingshu Li, et al. Design, synthesis,  and evaluation of orally bioavailable quinoline–indole derivatives  as innovative multitarget-directed ligands: promotion of cell proliferation  in the adult murine hippocampus for the treatment of Alzheimer’s disease.  Journal of Medicinal Chemistry 2018, 61, 1871-1894.

11. Zhiren Wang, Yali  Wang, Bo Wang, Wenrui Li, Ling Huang, et al. Design, synthesis and evaluation  of orally available clioquinol-moracin M hybrids as multi-target-directed  ligands for cognitive improvement in a rat model of neurodegeneration  in Alzheimer’s disease. Journal of Medicinal Chemistry 2015, 58, 8616-8637.