王志仁 教授

国家级青年人才项目入选者

电子邮件:zhirenwang@scut.edu.cn

办公地址：广州国际校区C1-b410

ORCID: https://orcid.org/0000-0002-2016-0517

2024-至今 华南理工大学生物医学科学与工程学院 教授

2019-2024 美国亚利桑那大学药学院 博士后

2017-2018 中山大学 特聘副研究员

2016-2016 美国加州大学San Diego分校 博士后

2011-2016 中山大学药学院 博士

生物医学工程（学博、学硕）、生物学（学博、学硕）、材料与化工（工程博士）、生物与医药（工程硕博）

脂质体药物、药物递送、纳米医学

致力于开发新型磷脂构建脂质体药物制剂平台用于药物递送、肿瘤免疫治疗以及神经退行性疾病创新疗法等方面。在Nature Nanotechnology、Nature Cancer、Nature Communications、Biomaterials、Journal of Controlled Release、Journal of Medicinal Chemistry等学术期刊发表20余篇研究论文，申请新型药物分子发明专利5项，授权3项，主持国家海外高层次引进人才青年项目，国家自然科学基金面上项目、青年科学基金及省部级项目。

代表性论文列表：

1. Zhiren Wang, Wenpan Li, Yanhao Jiang, Teng Ma, Mengwen Li, etal. A sphingolipid-derived Paclitaxel nanovesicle enhancesefficacy of combination therapies in triple negative breast cancer andpancreatic cancer. Nature Cancer 2025, 6,1734-1753.

2. Zhiren Wang, Jianqin Lu. A sphingolipid-derived paclitaxel nanovesicle for improvedcancer therapy. Nature Cancer 2025, 6, 1619-1620.

3. Zhiren Wang,Nicholas Little, Jiawei Chen, Kevin Tyler Lambesis, Kimberly Thi Le, et al.Immunogenic camptothesome nanovesicles comprised by sphingomyelin-derived camptothecinbilayers for safe and synergistic cancer immunochemotherapy. Nature Nanotechnology 2021, 16, 1130-1140.

4. Zhiren Wang,Wenpan Li, Yanhao Jiang, Tuyen Ba Tran, Leyla Estrella Cordova, et al. Sphingomyelin-derivednanovesicles for the delivery of the IDO1 inhibitor epacadostat enhancemetastatic and post-surgical melanoma immunotherapy. Nature Communications, 2023, 14, 7235.

5. Zhiren Wang,Wenpan Li, Jonghan Park, Karina Marie Gonzalez, Xiangmeng Wu, et al.Cholesterol-modified sphingomyelin chimeric lipid bilayer for fortified therapeuticdelivery. Nature Communications, 2024,15, 2073.

6. Zhiren Wang,Wenpan Li, Yanhao Jiang, Tuyen Ba Tran, Jinha Chung, et al. Camptothesome-basedcombination nanotherapeutic regimen for improved colorectal cancerimmunochemotherapy. Biomaterials, 2024, 306, 122477.

7. Zhiren Wang,Wenpan Li, Jonghan Park, Karina Marie Gonzalez, Aaron James Scott, et al. Camptothesome elicits immunogenic cell death to boost colorectalcancer immune checkpoint blockade. Journal ofControlled Release, 2022, 349, 929-939.

8. Zhiren Wang, Jiawei Chen, NicholasLittle, Jianqin Lu. Self-assembling prodrug nanotherapeuticsfor synergistic tumor targeted drug delivery. Acta Biomaterialia 2020, 111,20-28.

9. Zhiren Wang, Karina Marie Gonzalez, LeylaEstrella Cordova, Jianqin Lu. Nanotechnology-empowered therapeutics targetingneurodegenerative diseases. WIREs Nanomedicine & Nanobiotechnology 2023, 15,e1907.

10. Zhiren Wang,Jinhui Hu, Xiaoping Yang, Xing Feng, Xingshu Li, et al. Design, synthesis, and evaluationof orally bioavailable quinoline–indole derivatives as innovative multitarget-directedligands: promotion of cell proliferation in the adult murine hippocampus forthe treatment of Alzheimer’s disease. Journal of Medicinal Chemistry 2018, 61,1871-1894.

11. Zhiren Wang,Yali Wang, Bo Wang, Wenrui Li, Ling Huang, et al. Design, synthesisand evaluation of orally available clioquinol-moracin M hybrids as multi-target-directedligands for cognitive improvement in a rat model of neurodegeneration inAlzheimer’s disease. Journal of Medicinal Chemistry 2015, 58, 8616-8637.