张琨雨    教授（博导）

办公电话：020-81182184

电子邮件: kyuzhang@scut.edu.cn

办公地址：广州国际校区C1-b509

2021 — 2025 华南理工大学生物医学科学与工程学院 副教授

2019 — 2021 美国约翰霍普金斯大学  博士后

2018 — 2019  新加坡南洋理工大学  博士后

2014 — 2018  香港中文大学  博士

2010 — 2014  香港理工大学、中山大学  学士

生物医学工程（学博、学硕）、生物学（学博、学硕）、材料与化工（工程博士）、生物与医药（工程硕博）

生物材料、力学生物学、细胞工程、再生医学

主要研究方向包括仿生超分子水凝胶的设计制备, 实现细胞与类器官的三维培养, 探索组织发育、再生及疾病进展过程中的力学生物学现象，建立神经系统、肌肉骨骼系统等复杂组织损伤再生修复的新策略。先后主持国家重点研发计划青年科学家项目、广东省自然科学基金杰出青年项目、国家自然科学基金面上项目等科研项目, 以通讯/第一作者在Nat Chem、Sci Transl Med、Nat Commun、Sci Adv、JACS、AdvMater等国际顶尖期刊上发表论文40余篇, 4篇论文(曾)入围“ESI高被引论文”。2023-2025年连续入选美国斯坦福大学联合爱思唯尔数据库发布的“全球前2%年度影响力顶尖科学家”榜单；并以科研反哺教学，荣获广东省第七届高校（本科）青年教师教学大赛一等奖。担任中国生物材料学会烧创伤创面修复材料分会委员、中国研究型医院学会神经再生与修复专业委员会委员、广东省生物医学工程学会生物3D打印与再生医学分会青年委员会主任委员等。

代表性论文

[1]Yi,B.; +Li, H.; Chen, S.; Lian H.; Tan F.; Yao, H.; Xu, X.; *Zhang, K.; *Zhao, P.;*Bian, L. Superspreading and ultra-infiltrative coacervate mediates strongunderwater adhesion on hydrated and lipidic substrates. Nature Chemistry,2026.

[2]Ling,Q.; +Li, H.; Zhao, J.; Guo, W.; Yu, H.; Li, Z.; Hu, Y.; Wei S.; Fu, Y.; *ZhangY.; *Zhang, K.; *Bian, L. Mechanically heterogeneous hydrogel withcell-programmed network restructuring promotes tissue regeneration bymechano-epigenetic modulation. Nature Communications, 2026.

[3]Zhong,X.; +Liu, X.; +Luo, J.; Liu, X.; Wei, X.; Peng, X.; Wang, L.; Wang, H.; *Zhang,K.; *Bian, L.; *Shi, P. Cell surface engineering with a pseudo-fibrotic ECMreprograms the anti-fibrotic activity of mesenchymal stromal cells. ScienceAdvances, 2026, 12(3), aea0998.

[4]Li,J.; +Zhang, Y.; +Liu, Y.; Xu, Y.; Xu, H.; Ling, Q.; Tian, Z.; Ling, C.; Tang,Z.; Kiram, A.; Li, Y.; Hu, Z.; Qiu, Y.; *Bian, L.; *Zhu, Z.; *Zhang, K.; *Liu,Z. Dual-action bisphosphonate hydrogel preserves cortical bone integrity andrestores healing cascade in osteoporotic fracture-related infection. NatureCommunications, 2026, 17, 1276.

[5]Zhang,K.; +Zhu, H.; +Sun, Q.; +Yang, J.; Zhao, G.; *Wei, Q.; *Lin, M.; *Cao, Y.;*Bian, L. Materiomechanobiology: bridging material sciences, mechanics and cellbiology for advanced therapeutics. Materials Today, 2025, 90,353-374.

[6]Li,H.; +Wei, S.; +Ling, Q.; Wang, R.; Liu, T.; Yu, H.; Zhao, P.; *Zhang, K.;*Bian, L.; *Liao, W. Nanozyme-reinforced hydrogel spray as a reactive oxygenspecies-driven oxygenator to accelerate diabetic wound healing. AdvancedMaterials, 2025, 2504829.

[7]Lyu,Y.; Peng, M.; *Hu, Y.; Hu, X.; Zhang, Y.; Zhao, P.; *Wang, T.; *Xu, S.; *Zhang,K.; *Bian, L. Molecular tautomerism-induced formation of supramolecularhydrogel for mRNA enrichment and delivery. Cell Biomaterials,2025, 1(8), 100124.

[8]Zhao,J.; +Hu, Y.; +Li, H.; Liu, C.; Nie, Z.; Chen, Z.; Ling, Q.; Li, Z.; Zhao, P.;*Song, B.; *Zhang, K.; *Bian, L. Liquid–liquid phase separation-mediatedcellular-scale compartmentalization of hydrogel covalent crosslinking promotesmicrotubule-based mechanosensing. Journal of the American ChemicalSociety, 2025, 147(17), 14336-14347.

[9]Yang,B.; +Li, Z.; +Yang, Z.; Lin, S.; Wu, J.; Liu, W.; Yang, X.; Xie, X.; Zong, Z.;Lyu, Y.; Yang, Z.; Zhao, P.; Li, G.; *Ngai, T.; *Zhang, K.; *Bian, L.Recapitulating hypoxic metabolism in cartilaginous organoids via adaptivecell-matrix interactions enhances histone lactylation and cartilageregeneration. Nature Communications, 2025, 16, 2711.

[10] Chen,X.; Zhang, R.; Zhang, H.; Hu, X.; Wang, R.; Ling, Q.; *Shi, P.; *Zhang, K.;*Bian, L. Non-equilibrium hydrogel demonstrates cytocompatible and seamlessheterotrophic self-growth. Advanced Functional Materials,2025, 35(44), 2508978.

[11] Li,H.; +Lyu, Y.; +Wang, R.; Yu, H.; Lin, M.; Li, Z.; Zhong, Y.; *Sheng, P.;*Zhang, K.; *Liao, W.; *Bian, L. Supramolecular drug-laden hydrogel based onstructural tautomerization enhances drug delivery for rheumatoid arthritistreatment. Bioactive Materials, 2025, 53, 495-506.

[12] Xie,Q.; Yan, C.; Liu, G.; *Bian, L.; *Zhang, K. In-situ triggered self-contractionbioactive microgel assembly accelerates diabetic skin wound healing byactivating mechanotransduction and biochemical pathway. Advanced Materials, 2024, 202406434.

[13] Gao,Y.; +Wang, Y.; Zhang, J.; Zhang, M.; Dai, C.; Zhang, Y.; Zhang, L.; *Bian, L.;*Yang, Y.; *Zhang, K.; *Zhao, Y. Advancing neural regeneration via adaptablehydrogels: enriched with Mg2+ and silk fibroin to facilitateendogenous cell infiltration and macrophage polarization, Bioactive Materials, 2024, 33, 100-113.

[14]Wong,S.H.D.; +Yin, B.; Li, Z.; Yuan, W.; Zhang, Q.; Xie, X.; Tan, Y.; Wong, N.;*Zhang, K.; *Bian, L. Mechanical manipulation of cancer cell tumorigenicity viaheat shock protein signaling, ScienceAdvances, 2023, adg9593.

[15] Yang,X.; +Gao, S.; +Yang, B.; Yang, Z.; Lou, F.; Huang, P.; Zhao, P.; Guo, J.; Fang,H.; Chu, B.; He, M.; Wang, N.; Chan, A.H.L.; Chan, R.H.F.; *Wang, Z.; *Bian,L.; *Zhang, K. A bioinspired tumor-targeting and biomarker-activatablecell-material interfacing system enhances osteosarcoma treatment viabiomineralization, Advanced Science,2023, 202302272.

研究团队网站： https://www.x-mol.com/groups/bian_lab?lang=en

英才专访

星光领路人第5期|张琨雨：真正的研究，要么上书架，要么上货架