2019 -至今 华南理工大学 教授

2016-2019 美国罗德岛大学 助理教授

2013-2016 美国麻省理工学院 博士后

2009-2013 美国北卡罗莱纳大学教堂山分校分子药剂系 博士

2007-2009 北京大学药剂系 硕士

2003-2007 北京大学药学专业 学士

生物医学工程（学博、学硕）、生物学（学博、学硕）、材料与化工（工程博士）、药学（专硕）

生物制药与制药工程

主要从事纳米药物和基因递送，免疫治疗和疫苗开发等方面的研究, 包括利用纳米技术和生物工程技术设计开发新型纳米载体和RNA疫苗、递送功能性蛋白分子，用于相关疾病的预防和治疗。以第一或通讯作者在Nat Commun, Biomaterials, J. Control. Release, Mol. Ther., Nano Res.等期刊发表论文十余篇，参与撰写英文专著两部。申请或授权美国及国际发明专利三项，中国发明专利六项。曾主持或在研主持美国国立卫生研究院和基金会项目，国家海外引进人才青年项目、国家自然科学基金面上项目、广东省基础与应用基础研究基金等。

代表性论文：

1.GuibinLin, Huan Yan, Jing Sun, Jincun Zhao, YuanZhang*. Self-replicating RNAnanoparticle vaccine elicits protective immune responses against SARS-CoV-2. Molecular Therapy – Nucleic Acids, 2023(in press)

2.HuanYan, Guibin Lin, Zhanyan Liu, Fei Gu, YuanZhang*. Nano-adjuvants and immune agonists promote antitumor immunity ofpeptide amphiphiles. Acta Biomaterialia,161:213-225, 2023

3.HuanYan#, Zhanyan Liu#, Guibin Lin, Fei Gu, Yan Liu, YuxiaoXu, Xueli Kuang, Yuan Zhang#*. Systemic delivery of gemcitabineanalogue and STAT3 siRNA promotes antitumor immunity against melanoma. Nano Research, 15:9057-9072, 2022.

4.Yuan Zhang*,Xin Bush, Bingfang Yan, Justin A Chen. Gemcitabine nanoparticles promoteantitumor immunity against melanoma. Biomaterials,189:48-59, 2019

5.Yuan Zhang*,Na Li, Heikyung Suh, Darrell J. Irvine*. Nanoparticle anchoring targets immuneagonists to tumors enabling anti-tumor efficacy without systemic toxicity. Nature Communications, 9 (1): 6-20, 2018

6.Yuan Zhang,Lei Peng, Russell J Mumper, Leaf Huang. Combinational delivery of c-Myc siRNAand nucleoside analogues in a single, synthetic nanocarrier for targeted cancertherapy. Biomaterials. 34 (33): 8459-8468,2013.

7.JingYao*, Yuan Zhang*, Srinivas Ramishetti, Yuhua Wang, Leaf Huang. Turning anantiviral into an anticancer drug: nanoparticle delivery of acyclovirmonophosphate. Journal of ControlledRelease. 170 (3): 414-420, 2013.

8.Yuan Zhang,Nicole Mj Schwerbrock, Arlin B Rogers, William Y Kim, Leaf Huang. Codelivery ofVEGF siRNA and gemcitabine monophosphate in a single nanoparticle formulationfor effective treatment of NSCLC. MolecularTherapy. 21 (8): 1559-69, 2013.

9. YuanZhang, William Y Kim, LeafHuang. Systemic delivery of gemcitabine triphosphate via LCP nanoparticles forNSCLC and pancreatic cancer therapy. Biomaterials.34 (13): 3447-58, 2013.

10.YuanZhang, Andrew Satterlee,Leaf Huang. In vivo gene delivery by nonviral vectors: overcoming hurdles? Molecular Therapy. 20 (7): 1298-304,2012.

11.Yuan Zhang*, XueqingWang, Jiancheng Wang, Xuan Zhang, Qiang Zhang*. Octreotide-modified polymericmicelles as potential carriers for targeted docetaxel delivery to somatostatinreceptor overexpressing tumor cells. PharmaceuticalResearch. 28 (5): 1167-78, 2011.