张元教授（PI）

办公电话:

电子邮件:

mczhang@scut.edu.cn

办公地址：广州国际校区C1-b315

2019 -至今 华南理工大学 教授

2016-2019 美国罗德岛大学 助理教授

2013-2016 美国麻省理工学院 博士后

2009-2013 美国北卡罗莱纳大学教堂山分校分子药剂系 博士

2007-2009 北京大学药剂系 硕士

2003-2007 北京大学药学专业 学士

生物制药与制药工程

主要从事纳米药物和基因递送，免疫治疗和疫苗开发等方面的研究, 包括利用纳米技术和生物工程技术设计开发新型纳米载体和RNA疫苗、递送功能性蛋白分子，用于相关疾病的预防和治疗。以第一或通讯作者在Nat Commun, Biomaterials, J. Control. Release, Mol. Ther., Nano Res.等期刊发表论文十余篇，参与撰写英文专著两部。申请或授权美国及国际发明专利三项，中国发明专利六项。曾主持或在研主持美国国立卫生研究院和基金会项目，国家海外引进人才青年项目、国家自然科学基金面上项目、广东省基础与应用基础研究基金等。

代表性论文：

1.Huan Yan, Guibin Lin, Zhanyan Liu, Fei Gu, Yuan Zhang*. Nano-adjuvants and immuneagonists promote antitumor immunity of peptide amphiphiles. Acta Biomaterialia, 2023

2.Huan Yan, Zhanyan Liu, Guibin Lin, Fei Gu, YanLiu, Yuxiao Xu, Xueli Kuang, Yuan Zhang*.Systemic delivery of gemcitabine analogue and STAT3 siRNA promotes antitumorimmunity against melanoma. Nano Research,15:9057-9072, 2022.

3.Yuan Zhang*, Xin Bush, BingfangYan, Justin A Chen.  Gemcitabinenanoparticles promote antitumor immunity against melanoma.  Biomaterials,189:48-59, 2019

4.Yuan Zhang*, Na Li, HeikyungSuh, Darrell J. Irvine*.  Nanoparticleanchoring targets immune agonists to tumors enabling anti-tumor efficacywithout systemic toxicity.  Nature Communications, 9 (1): 6, 2018

5.Yuan Zhang, Lei Peng, RussellJ Mumper, Leaf Huang*.  Combinationaldelivery of c-Myc siRNA and nucleoside analogues in a single, syntheticnanocarrier for targeted cancer therapy.  Biomaterials.34 (33): 8459-68, 2013.

6.Jing Yao#, Yuan Zhang#, SrinivasRamishetti, Yuhua Wang, Leaf Huang*.  Turningan antiviral into an anticancer drug: nanoparticle delivery of acyclovirmonophosphate.  Journal of Controlled Release. 170 (3): 414-420, 2013.

7.Yuan Zhang,Nicole Mj Schwerbrock, Arlin B Rogers, William Y Kim, Leaf Huang*.  Codelivery of VEGF siRNA and gemcitabinemonophosphate in a single nanoparticle formulation for effective treatment ofNSCLC.  Molecular Therapy. 21(8): 1559-69, 2013.

8.YuanZhang, William Y Kim, LeafHuang*.  Systemic delivery of gemcitabine triphosphatevia LCP nanoparticles for NSCLC and pancreatic cancer therapy.  Biomaterials.34 (13): 3447-58, 2013.

9.YuanZhang, Andrew Satterlee,Leaf Huang*.  In vivo gene delivery by nonviral vectors:overcoming hurdles?  Molecular Therapy. 20 (7): 1298-304, 2012.

10.Yuan Zhang*, Xueqing Wang, JianchengWang, Xuan Zhang, Qiang Zhang*.  Octreotide-modifiedpolymeric micelles as potential carriers for targeted docetaxel delivery tosomatostatin receptor overexpressing tumor cells.  PharmaceuticalResearch. 28 (5): 1167-78, 2011.