沈松 教授 （博导）

国家级青年人才项目入选者

电子邮件:

shensong@scut.edu.cn

办公地址：

广州国际校区C1-c807

实验室网站链接：https://www2.scut.edu.cn/nanomedicine/yjtdcy/list.htm

2025.10-至今  华南理工大学生物医学科学与工程学院 教授

2019.09-2025.10 华南理工大学生物医学科学与工程学院 副教授

2017—2019 华南理工大学医学院 博士后

2011—2017 中国科学技术大学 博士

2007—2011 安徽师范大学 学士

生物医学工程（学博、学硕）、生物学（学博、学硕）、材料与化工（工程博士）、生物与医药（工程硕博）

抗体工程、蛋白和核酸药物递送载体、肿瘤免疫治疗

主要从事生物大分子药物递送载体的研究，在Nature Biomedical Engineering、Nature Communications、AdvancedMaterials、Nano Today等国际知名学术期刊共发表论文50余篇，总被引3500余次，其中以一作或通讯作者发表的论文26篇。申请中国发明专利、美国发明专利、PCT专利共17项，已授权8项；参与撰写2部著作的章节。先后主持国家自然科学基金青年科学基金（B类）[原“优青”]、广东省自然科学基金杰出青年项目、国家自然科学基金面上项目（3项）、青年科学基金项目及博士后创新人才支持计划等，作为核心骨干参与国家重点研发计划、广州市重点领域研发计划等项目。

1.Ya-Nan Fan, Long Zhu, Yu-Xin Qing, Si-Yi Ye,Qian-Ni Ye, Xiao-Yi Huang, Dong-Kun Zhao, Tai-Yu Tian, Fang-Chao Li, Guan-RongYan, Xian-Zhu Yang, Song Shen*, Jun Wang*, Engineering multi-specificnano-antibodies based on a versatile nano-adaptor for cancer immunotherapy, NatureBiomedical Engineering, 2025, doi: 10.1038/s41551-025-01425-5.

2.Qian-Ni Ye, Long Zhu, Jie Liang, Dong-KunZhao, Tai-Yu Tian, Ya-Nan Fan, Si-Yi Ye, Hua Liu, Xiao-Yi Haung, Zhi-Ting Cao, Song Shen*, Jun Wang*, Orchestrating NK and T cells via tri-specificNano-Antibodies for synergistic antitumor immunity, NatureCommunications, 2024, 15, 6211.

3. Cheng-Tao Jiang#, Kai-Ge Chen#,An Liu, Hua Huang, Ya-Nan Fan, Dong-Kun Zhao, Qian-Ni Ye, Hou-Bing Zhang,Cong-Fei Xu, Song Shen*, Meng-Hua Xiong, Jin-Zhi Du, Xian-Zhu Yang, Jun Wang*, Immunomodulating nano-adaptors potentiate antibody-based cancerimmunotherapy. Nature Communications,2021, 12, 1359.

4.Hua Huang#, Qi-Song Tong#,Jing-Yang Zhang, Rong Liu, Yang Chen, Song Shen*, Jin-Zhi Du*, Jun Wang, Phagocytosis-Activating Nanocomplex OrchestratesMacrophage-Mediated Cancer Immunotherapy, Advanced Materials, 2025,e2500982.

5.Jie Liang#, Dong-Kun Zhao#, Hao-Ming Yin, Tai-YuTian, Jian-Kang Kang, Song Shen*, Jun Wang, Combinatorial screening ofnanomedicines in patient-derived cancer organoids facilitates efficient cancertherapy, Nano Today, 2025, 61, 102665.

6.Boya Yu, Zekai Xiao, Shuaiqi Shao, Mingda Yang, Houjin Jing, Song Shen*,Ziyang Cao*, and Xianzhu Yang*, An Iron-Polyphenol Decorated siRNA-EncapsulatedNanomedicine Multifacetedly Promoted Macrophage Phagocytosis forSynergistic Ferroptosis-Immunotherapy, Advanced Functional Materials,2025, 2417548.

7.Zheng Zhang#, Ya-Nan Fan#, Si-Qi Jiang, Ya-JingMa, Yao-Ru Yu, Yu-Xin Qing, Qian-Ru Li, Yi-Lin Liu, Song Shen*, Jun Wang*,Recent Advances in mRNA Delivery Systems for Cancer Therapy, AdvancedScience, 2025, e17571.

8.Qi-Song Tong#, Hua Huang#,Hui-Han Yu, Rong Liu, Song Shen*, Jin-Zhi Du*, A Size-switchableNanocluster Remodels the Immunosuppressive Microenvironment of Tumor andTumor-draining Lymph Nodes for Improved Cancer Immunotherapy, Biomaterials,2025, 315, 122910.

9.Kai-Ge Chen#,An Liu#, Cheng-Tao Jiang, Dong-Kun Zhao, Qian-Ni Ye, Yu-Qi Liao,Cong-Fei Xu, Song Shen*, Jun Wang, Dual-functional super bispecificnano-antibodies derived from monoclonal antibodies potentiate the antitumoreffect of innate immune cells. Nano Today 2021, 39, 101209.

10.Qian-Ni Ye#, Yue Wang#, Song Shen*, Cong-FeiXu, Jun Wang*, Biomaterials-Based Delivery of Therapeutic Antibodies for CancerTherapy, Advanced Healthcare Materials, 2021,2002139.