袁友永 教授
国家级青年人才项目入选者
办公电话:
020-81182186
电子邮件:
yuanyy@scut.edu.cn
办公地址：
广州国际校区C1-c908
袁友永 教授
国家级青年人才项目入选者
2017-至今 华南理工大学 教授
2012-2017 新加坡国立大学 博士后 （导师：刘斌 教授）
2007-2012 中国科学技术大学 博士 （导师：王均 教授）
2003-2007 安徽大学 学士
生物医学工程、生物学、材料与化工、药学
纳米药物与药物递送系统、生物医用材料、生物成像
主要从事生物医用高分子在药物递送、荧光探针和肿瘤免疫治疗等方面的研究。先后在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Adv. Mater.等国际著名杂志上发表SCI学术论文五十余篇，获得授权专利7项。主持海外高层次引进人才青年项目、科技部重点研发计划课题、国家自然科学基金等项目。
代表性论文：
1. Yansong Dong, Ye Liu, Yalan Tu, Youyong Yuan,* Jun Wang.* AIEgens Cross-Linked Iron OxideNanoparticles Synchronously Amplify Bimodal Imaging Signals in Situ by TumorAcidity-Mediated Click Reaction. Angew.Chem. Int. Ed.2023, 62, e202310975.
2.Yansong Dong, Yalan Tu, Ye Liu, Maolin Jiang, EmilBulatov, YouyongYuan,*Jun Wang.*Perivascular nanocarrier aggregation as a drug reservoir augments tumor drug delivery andtreatmentefficacy. NanoToday, 2023, 53, 102004.
3.YangyangZhao, Yansong Dong, Shuhan Yang, Yalan Tu, Chengbo Wang, Jun Li, Youyong Yuan,* Zhexiong Lian. Bioorthognal Equipping CAR-TCells with Hyaluronidase and Checkpoint Blocking Antibody for Enhanced SolidTumor Immunotherapy, ACSCentral Science,2022, 8, 603–614.
4.KeweiWang, Maolin Jiang, Jielian Zhou, Ye Liu, Qingyu Zong, and Youyong Yuan.* Tumor-Acidity and BioorthogonalChemistry-Mediated On-Site Size Transformation Clustered Nanosystem to OvercomeHypoxic Resistance and Enhance Chemoimmunotherapy, ACS Nano, 2022, 16, 721–735.
5.YalanTu, Xuan Xiao, Yansong Dong, Jisi Li, Ye Liu, Qingyu Zong, Youyong Yuan*, Cinnamaldehyde-based poly(thioacetal): AROS-awakened self-amplifying degradable polymer for enhanced cancerimmunotherapy, Biomaterials, 2022, 289, 121795.
6.Kewei Wang, Xuan Xiao, Ye Liu, Qingyu Zong, YalanTu, YouyongYuan*, Self-immolativepolyprodrug-based tumor-specific cascade amplificated drug release nanosystemfor orchestrated synergistic cancer therapy, Biomaterials, 2022, 289, 121803.
7.Kewei Wang,Xuan Xiao, MaolinJiang, Jisi Li, Jielian Zhou, Youyong Yuan.* An NIR-Fluorophore-Based Theranostic forSelective Initiation of Tumor Pyroptosis-Induced Immunotherapy, Small, 2021, 17, 2102610.
8.Fangzhou Yu, Yalan Tu, Shiwei Luo,Xuan Xiao, Wang Yao, Maolin Jiang, Xinqing Jiang,* Ruimeng Yang,* Youyong Yuan.* Dual-Drug Backboned Polyprodrug with a Predefined Drug Combination forSynergistic Chemotherapy, Nano Letters, 2021, 21, 2216.
9.Xuan Xiao, KeweiWang, Qingyu Zong, Yalan Tu, Yansong Dong, Youyong Yuan.* Polyprodrugwith Glutathione Depletion and Cascade Drug Activation for Multi-drugResistance Reversal, Biomaterials, 2021, 270, 120649.
10.Yansong Dong, Yalan Tu,Kewei Wang, Congfei Xu, Youyong Yuan,* Jun Wang.* A General Strategyfor Macrotheranostic Prodrug Activation: Synergy by Tumor AcidicMicroenvironment and Bioorthogonal Chemistry. Angew. Chem. Int. Ed., 2020, 59, 7168-7172.