王均 教授

办公电话:

020-81182182

电子邮件:

mcjwang@scut.edu.cn

办公地址：广州国际校区C1-c808

国家自然科学基金杰出青年获得者、国家重点研发计划项目负责人、“十四五”科技部“高端功能与智能材料”重点研发专项总体专家组成员；

国际生物材料科学与工程会士、英国皇家化学会会士、中国生物材料学会首届会士、“万人计划”科技创新领军人才、科技部“中青年科技创新领军人才”、中国科学院“百人计划”；

Biomaterials副主编，Advanced HealthcareMaterials、ActaBiomaterialia、Journalof Controlled Release、Aggregate等编委，Biomaterials Science、ChemNanoMat等顾问编委，《生物材料科学与工程》丛书执行副总主编，《中国卫生标准管理》杂志社第一届药品监管科学与现代药事管理编委会副主编，中国生物材料学会常务理事，中国生物材料学会智能仿生生物材料分会主任委员等

实验室网站链接：https://www2.scut.edu.cn/nanomedicine/yjtdcy/list.htm

2018-至今，华南理工大学生物医学科学与工程学院，教授，创院院长

2018-至今，国家人体组织功能重建工程技术研究中心，副主任

2019-2021，广东省生物医学工程重点实验室，主任

2016-2020，华南理工大学生命科学研究院，教授

2006-2016，中国科学技术大学生命科学学院，教授；合肥微尺度物质科学国家实验室（筹），研究员；中科院天然免疫和慢性疾病重点实验室，副主任；中国科学技术大学医学中心，副主任

2006.06-2006.08，德国罗斯托克大学医学院，高级访问教授

2004-2006，中国科学技术大学高分子科学与工程系，教授

2002-2004，约翰霍普金斯大学医学院生物医学工程系，博士后

1999-2002，Johns Hopkins Singapore，博士后

1993-1998，武汉大学，博士，高分子化学与物理专业

1989-1993，武汉大学，学士，主修化学专业，辅修细胞生物学专业

生物医学工程（学博、学硕）、材料与化工（工程博士）、生物学（学博、学硕）、药学（专硕）

纳米生物医学、药物递送系统、肿瘤免疫和生物治疗、mRNA疫苗

在Nat.Nanotechnol.、Sci. Transl. Med.、Nat. Commun.、Proc. Natl.Acad. Sci. U. S. A.、Angew. Chem. Int. Ed.等杂志发表研究论文250余篇，被引用22600余次，H-Index 81；2021~2023年入选科睿唯安“高被引科学家”和爱思唯尔中国高被引学者；申请发明专利40余件，授权22件；获国家自然科学奖二等奖、广东省科学技术奖一等奖、教育部自然科学奖一等奖、中国生物材料学会科学技术奖、第二届生物医用高分子材料大会“杰出贡献奖”、国际药物控制释放协会“Capsugel Awardon Innovative Aspects of Gastrointestinal Drug Absorption and Delivery”等；主持国家重点研发计划、国家自然科学基金重点等研究项目。

代表性论文列表：

[1] Mingdong Liu#, LiangqiHuang#, Weinan Zhang#, Xiaochuan Wang, Yuanyuan Geng, Yuhao Zhang, Li Wang,Wenbin Zhang, Yun-Jiao Zhang, Shiyan Xiao*, Yan Bao*, Menghua Xiong*, JunWang*, ATransistor-Like pH-Sensitive Nanodetergent for Selective Cancer Therapy, NatureNanotechnology, 2022, 17, 541-551.

[2] Gui Zhao#, Yue Zhang#,Cong-Fei Xu*, Jun Wang*, In VivoProduction of CAR-T Cells Using Virus-mimetic Fusogenic Nanovesicles, Science Bulletin, 2024, 69, 354-366.

[3]Kuirong Mao, Jialiang Wang,Qianyue Xie, Yong-Guang Yang, Song Shen, Tianmeng Sun, Jun Wang*, Cationic Nanoparticles-based Approaches for ImmuneTolerance Induction In Vivo, Journal ofControlled Release, 2024, 366, 425-447.

[4]Junbin Chen, Miao Su,Congfei Xu, Ziyang Cao, Xianzhu Yang*, JunWang*, Cationic Lipid-Polymer Hybrid Nanoparticle Drives in situ Generationand Lymphatic Navigation of Tumor Antigens to Prime Systemic AntitumorImmunity, Nano Today, 2024, 57,102335.

[5]Yansong Dong#, Ye Liu#,Yalan Tu, Youyong Yuan*, Jun Wang*,AIEgens Cross-linked Iron Oxide Nanoparticles Synchronously Amplify BimodalImaging Signals in Situ by Tumor Acidity-Mediated Click Reaction, Angewandte Chemie International Edition,2023, 62, e202310975.

[6]Yue Wang#, Shi-Kun Zhou#,Yan Wang, Zi-Dong Lu, Yue Zhang, Cong-Fei Xu*, Jun Wang*, Engineering Tumor-Specific Gene Nanomedicine to Recruitand Activate T Cells for Enhanced Immunotherapy, Nature Communications, 2023, 14, 1993.

[7]Yue Zhang#, Gui Zhao#, JingLiu, Hou-Bing Zhang, Yue Wang, Ying-Li Luo, Zi-Dong Lu, Xiao-Jiao Du, SongShen, Jin-Zhi Du, Cong-Fei Xu*, Jun Wang*,Gene-Activating Nanomedicine for the Tumor-Oriented Infiltration of T Cells toEnhance Immunotherapy against Solid Tumors, NanoToday, 2023, 52, 101992.

[8]Yansong Dong#, Yalan Tu#, YeLiu, Maolin Jiang, Emil Bulatov, Youyong Yuan*, Jun Wang*, Perivascular Nanocarriers Aggregation as Drug ReservoirsAugments Tumor Drug Delivery and Treatment Efficacy, Nano Today, 2023, 53,102004.

[9]Yue Zhang, Gui Zhao, Yi-FangChen, Shi-Kun Zhou, Yue Wang, Yi-Qun Sun, Song Shen, Cong-Fei Xu*, Jun Wang*, Engineering Nano-ClusteredMultivalent Agonists to Cross-Link TNF Receptors for Cancer Therapy, Aggregate, 2023, 4, e393.

[10]Mengwen Huang#, Songrong Wang#, Senbiao Chen#, Jilong Wang,Congfei Xu, Jing Liu, Zhexiong Lian*, Xiaojiao Du*, Jun Wang*, Pegylated Liposomal Mitoxantrone Modulates Tumor ImmuneLandscape to Boost PD-L1 Blockade Therapy, NanoToday, 2022, 44, 101500.

[11]Jia Shi#, Meng-Wen Huang#, Zi-Dong Lu, Xiao-Jiao Du, Song Shen,Cong-Fei Xu*, Jun Wang*, Delivery ofmRNA for Regulating Functions of Immune Cells, Journal of Controlled Release, 2022, 345, 494-511.

[12]Wei-Hai Chen, Qi-Wen Chen, Qian Chen, Chunyan Cui, Shun Duan,Yongyuan Kang, Yang Liu, Yun Liu, Wali Muhammad, Shiqun Shao, Chengqiang Tang,Jinqiang Wang, Lei Wang, Meng-Hua Xiong, Lichen Yin, Kuo Zhang, Zhanzhan Zhang,Xu Zhen, Jun Feng*, Changyou Gao*, Zhen Gu*, Chaoliang He*, Jian Ji*, XiqunJiang*, Wenguang Liu*, Zhuang Liu*, Huisheng Peng*, Youqing Shen*, Linqi Shi*,Xuemei Sun*, Hao Wang*, Jun Wang*,Haihua Xiao*, Fu-Jian Xu*, Zhiyuan Zhong*, Xian-Zheng Zhang*, Xuesi Chen*,Biomedical Polymers: Synthesis, Properties, and Applications, SCIENCE CHINA Chemistry, 2022, 65,1010-1075.

[13]Cheng-Tao Jiang#, Kai-Ge Chen#, An Liu, Hua Huang, Ya-Nan Fan,Dong-Kun Zhao, Qian-Ni Ye, Hou-Bing Zhang, Cong-Fei Xu, Song Shen*, Meng-HuaXiong, Jin-Zhi Du, Xian-Zhu Yang, JunWang*, Immunomodulating Nano-Adaptors Potentiate Antibody-Based CancerImmunotherapy, Nature Communications,2021, 12, 1359.

[14]Yansong Dong, Yalan Tu, Kewei Wang, Congfei Xu, Youyong Yuan*, Jun Wang*, A General Strategy forMacrotheranostic Prodrug Activation: Synergy between the Acidic TumorMicroenvironment and Bioorthogonal Chemistry. Angewandte Chemie International Edition, 2020, 59, 7168-7172.

[15]Hong-Jun Li#, Jing Liu#, Ying-Li Luo, Sen-Biao Chen, Rong Liu,Jin-Zhi Du*, Jun Wang*, IntratumorPerformance and Therapeutic Efficacy of PAMAM Dendrimers Carried by ClusteredNanoparticles. Nano Letter, 2019, 19,8947-8955.

[16]Hua Huang, Cheng-Tao Jiang, Song Shen*, An Liu, Yun-Jiu Gan,Qi-Song Tong, Sen-Biao Chen, Zhu-Xin Gao, Jin-Zhi Du, Jie Cao*, Jun Wang*, Nanoenabled Reversal ofIDO1-Mediated Immunosuppression Synergizes with Immunogenic Chemotherapy forImproved Cancer Therapy. Nano Letter,2019, 19, 5356-5365.

[17]Jin-Zhi Du*, Hong-Jun Li, JunWang*, Tumor-Acidity Cleavable Maleic Acid Amide (TACMAA): A Powerful Toolfor Designing Smart Nanoparticles to Overcome Delivery Barriers in CancerNanomedicine, Accounts of ChemicalResearch, 2018, 51, 2848-2856.

[18]Cong-Fei Xu#, Zi-Dong Lu#, Ying-Li Luo, Yang Liu, Zhi-Ting Cao,Song Shen, Hong-Jun Li, Jing Liu, Kai-Ge Chen, Zhi-Yao Chen, Xian-Zhu Yang,Zhen Gu, Jun Wang*, Targeting ofNLRP3 Inflammasome with Gene Editing for the Amelioration of InflammatoryDiseases, Nature Communications,2018, 9, 4092.

[19]Hong-Jun Li#, Jin-Zhi Du#, Xiao-Jiao Du#,Cong-Fei Xu, Chun-Yang Sun, Hong-Xia Wang, Zhi-Ting Cao, Xian-Zhu Yang, Yan-HuaZhu, Shu-Ming Nie*, Jun Wang*,Stimuli-responsive Clustered Nanoparticles for Improved Tumor Penetration andTherapeutic Efficacy, Proceedings of the National Academy of Sciences of theUnited States of America, 2016, 113, 4164-4169.

[20]Yan-Dan Yao#, Tian-Meng Sun#, Song-Yin Huang, Shuang Dou, LingLin, Jia-Ning Chen, Jian-Bin Ruan, Cheng-Qiong Mao, Feng-Yan Yu, Mu-Sheng Zeng,Jian-Ye Zang, Qiang Liu, Feng-Xi Su, Peter Zhang, Judy Lieberman*, JunWang*, Erwei Song*, Targeted Delivery of PLK1-siRNA by ScFvSuppresses Her2+ Breast Cancer Growth and Metastasis, Science TranslationalMedicine, 2012, 4, 130ra48 (Highlighted by Nature Review Cancer)

论文详细列表：http://www.researcherid.com/rid/F-9033-2011