袁友永教授
办公电话:
020-81182186
电子邮件:
yuanyy@scut.edu.cn
办公地址：广州国际校区C1-c807
2017-至今 华南理工大学 教授
2012-2017 新加坡国立大学 博士后 （导师：刘斌 教授）
2007-2012 中国科学技术大学 博士 （导师：王均 教授）
2003-2007 安徽大学 学士
生物医学工程、生物学、材料与化工、药学
纳米药物与药物递送系统、生物医用材料、生物成像
主要从事生物医用高分子在药物递送、荧光探针和肿瘤免疫治疗等方面的研究。先后在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Adv. Mater.等国际著名杂志上发表SCI学术论文五十余篇，获得授权专利7项。主持海外高层次引进人才青年项目、科技部重点研发计划课题、国家自然科学基金等项目。
代表性论文：
1. Maolin Jiang, Ye Liu, Yansong Dong, Kewei Wang, and Youyong Yuan.* Bioorthogonal Chemistry and Illumination Controlled Programmed Size-Changeable Nanomedicine for Synergistic Photodynamic and Hypoxia-Activated Therapy, Biomaterials, 2022, 284, 121480.
2. Yangyang Zhao, Yansong Dong, Shuhan Yang, Yalan Tu, Chengbo Wang, Jun Li, Youyong Yuan,* Zhexiong Lian. Bioorthognal Equipping CAR-T Cells with Hyaluronidase and Checkpoint Blocking Antibody for Enhanced Solid Tumor Immunotherapy, ACS Central Science, 2022, 8, 603–614.
3. Kewei Wang, Maolin Jiang, Jielian Zhou, Ye Liu, Qingyu Zong, and Youyong Yuan.* Tumor-Acidity and Bioorthogonal Chemistry-Mediated On-Site Size Transformation Clustered Nanosystem to Overcome Hypoxic Resistance and Enhance Chemoimmunotherapy, ACS Nano, 2022, 16, 721–735.
4. Yalan Tu, Xuan Xiao, Yansong Dong, Jisi Li, Ye Liu, Qingyu Zong, Youyong Yuan*,Cinnamaldehyde-based poly(thioacetal): A ROS-awakened self-amplifying degradable polymer for enhanced cancer immunotherapy, Biomaterials, 2022, 289, 121795.
5. Kewei Wang, Xuan Xiao, Ye Liu, Qingyu Zong, Yalan Tu, Youyong Yuan*, Self-immolative polyprodrug-based tumor-specific cascade amplificated drug release nanosystem for orchestrated synergistic cancer therapy, Biomaterials, 2022, 289, 121803.
6. Kewei Wang,Xuan Xiao, Maolin Jiang, Jisi Li, Jielian Zhou, Youyong Yuan.* An NIR-Fluorophore-Based Theranostic for Selective Initiation of Tumor Pyroptosis-Induced Immunotherapy, Small, 2021, 17, 2102610.
7. Fangzhou Yu,† Yalan Tu,† Shiwei Luo, Xuan Xiao, Wang Yao, Maolin Jiang, Xinqing Jiang,* Ruimeng Yang,* Youyong Yuan.* Dual-Drug Backboned Polyprodrug with a Predefined Drug Combination for Synergistic Chemotherapy, Nano Letters, 2021, 21, 2216.
8. Xuan Xiao,† Kewei Wang,† Qingyu Zong,Yalan Tu,Yansong Dong, Youyong Yuan.* Polyprodrug with Glutathione Depletion and Cascade Drug Activation for Multi-drug Resistance Reversal, Biomaterials, 2021, 270, 120649.
9. Yalan Tu, Yansong Dong, Kewei Wang, Song Shen, Youyong Yuan,* Jun Wang.* Intercellular Delivery of Bioorthogonal Chemical Receptors for Enhanced Tumor Targeting and Penetration, Biomaterials, 2020, 259, 120298.
10. Yansong Dong, Yalan Tu, Kewei Wang, Congfei Xu, Youyong Yuan,* Jun Wang.* A General Strategy for Macrotheranostic Prodrug Activation: Synergy by Tumor Acidic Microenvironment and Bioorthogonal Chemistry. Angew. Chem. Int. Ed., 2020, 59, 7168-7172.