袁友永 教授
国家级青年人才项目入选者
办公电话:
020-81182186
电子邮件:
yuanyy@scut.edu.cn
办公地址：
广州国际校区C1-c908
袁友永 教授
国家级青年人才项目入选者
2017-至今 华南理工大学 教授
2012-2017 新加坡国立大学 博士后 （导师：刘斌 教授）
2007-2012 中国科学技术大学 博士 （导师：王均 教授）
2003-2007 安徽大学 学士
生物医学工程（学博、学硕）、生物学（学博、学硕）、材料与化工（工程博士）、生物与医药（工程硕博）
纳米药物与药物递送系统、生物医用材料、生物成像
主要从事生物医用高分子在药物递送、荧光探针和肿瘤免疫治疗等方面的研究。先后在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Adv. Mater.等国际著名杂志上发表SCI学术论文五十余篇，获得授权专利7项。主持海外高层次引进人才青年项目、科技部重点研发计划课题、国家自然科学基金等项目。
代表性论文：
1. Qiaoling Tan#, Yandong Zhao#, Yangning Zhang#, Hao Chen, Zhiqi Xu, Zhenhai Pan, Mohamed E El-Khouly, Youyong Yuan*. Inhalable Polymeric PROTACNanococktail for Targeted Protein Degradation in Idiopathic Pulmonary Fibrosis. J. Am.Chem. Soc., 2026, 148,27869-27883.
2. He Dong, Cilong Chu, IhsanUllah, Qing Xu, Zhenhai Pan, Youyong Yuan*. Split-Deliver-Click: Tumor-Specific Protein Degradation viaAND Logic-Gated In-Cell Bioorthogonal Clicking of PROTACs. Angew. Chem. Int. Ed., 2026, 65, e20774.
3. Ye Liu, Maolin Jiang, MengchaoDing, Ihsan Ullah, Haiyang Wang, Wenjiao Xie, Kewei Wang, Youyong Yuan*. PROTAC-based synthetic lethalitystrategy endogenously activates systemic STlNG boost antitumour immunity. Sci. Adv., 2026, 12, eado7448.
4. Maolin Jiang, Ye Liu, KeweiWang, Yansong Dong, Xiangyu Hu, Youyong Yuan*. Mutual Reinforced Activatable NIR Fluorescence/MR Bimodal ImagingEnabled by Tumor-Specific Biomarker Amplification in Positive Feedback Loop. Cell Biomater., 2025, 1, 10044.
5. Taosha Jin, Haiyang Wang, IhsanUllah, Wenjiao Xie, Taian Lin, Qiaoling Tan, Xiaoyu Pan, Youyong Yuan*, A Wireless Operated FlexibleBioelectronic Microneedle Patch for Actively Controlled Transdermal DrugDelivery, Adv.Mater., 2025, 37, e2417136.
6. Tao Li, Qingyu Zong, He Dong,Ihsan Ullah, Zhenhai Pan, Youyong Yuan*, Non-invasive monitoring of PROTACs mediated protein degradation in vivousing an environment-sensitive reporter. Nat. Commun., 2025, 16, 1892.
7. Mengchao Ding, Qingyu Zong, DanZhang, Ihsan Ullah, Xingzu Zhang, Wenhua Liang, Xinchun Li, Emil Bulatov, Youyong Yuan*. Self-Adaptive NanocarriersOvercome Multiple Physiological Barriers to Boosting Chemotherapy of OrthotopicPancreatic Cancer. ACS Nano, 2025, 19, 662-679.
8. Qingyu Zong, Jun Li, Qing Xu,Ye Liu, Kewei Wang, Youyong Yuan*. Self-immolative Poly(thiocarbamate) with Localized H2SSignal Amplification for Precise Cancer Imaging and Therapy. Nat. Commun., 2024, 15, 7558.
9. Kewei Wang, Maolin Jiang, TaoLi, Ye Liu, Qingyu Zong, Qing Xu, Ihsan Ullah, Yahui Chen, Wei Xue, Youyong Yuan*. A Synergistic ChemoimmunotherapySystem Leveraging PD-L1 Blocking and Bioorthogonal Prodrug Activation. Adv. Mater., 2024, 36, e2402322.
10. Yansong Dong, Ye Liu, YalanTu, Youyong Yuan*, Jun Wang*. AIEgens Cross-Linked Iron Oxide NanoparticlesSynchronously Amplify Bimodal Imaging Signals in Situ by Tumor Acidity-MediatedClick Reaction. Angew.Chem. Int. Ed., 2023, 62, e202310975.
11. Kewei Wang, Maolin Jiang,Jielian Zhou, Ye Liu, Qingyu Zong, Youyong Yuan*. Tumor-Acidity and Bioorthogonal Chemistry-Mediated On-Site SizeTransformation Clustered Nanosystem to Overcome Hypoxic Resistance and EnhanceChemoimmunotherapy. ACS Nano, 2022, 16, 721-735.
12. Yansong Dong, Yalan Tu, KeweiWang, Congfei Xu, YouyongYuan*, Jun Wang*. A General Strategy for Macrotheranostic ProdrugActivation: Synergy by Tumor Acidic Microenvironment and BioorthogonalChemistry. Angew.Chem. Int. Ed., 2020,59, 7168-7172.
论文详细列表：https://webofscience.clarivate.cn/wos/author/record/L-4466-2017