王均 教授

办公电话:

020-81182182

电子邮件:

mcjwang@scut.edu.cn

办公地址：广州国际校区C1-c808

国家自然科学基金杰出青年获得者、国家重点研发计划项目负责人、“十四五”科技部“高端功能与智能材料”重点研发专项总体专家组成员；

国际生物材料科学与工程学会联合会会士、英国皇家化学会会士、中国生物材料学会首届会士、“万人计划”科技创新领军人才、科技部“中青年科技创新领军人才”、中国科学院“百人计划”；

Biomaterials副主编，Advanced Healthcare Materials、Acta Biomaterialia、Journal of Controlled Release、Aggregate等编委，Biomaterials Science、ChemNanoMat等顾问编委，《生物材料科学与工程》丛书执行副总主编，《中国卫生标准管理》杂志社第一届药品监管科学与现代药事管理编委会副主编，中国生物材料学会常务理事，中国生物材料学会智能仿生生物材料分会主任委员等

实验室网站链接：https://www2.scut.edu.cn/nanomedicine/yjtdcy/list.htm

2018-至今，华南理工大学生物医学科学与工程学院，教授，创院院长

2018-至今，国家人体组织功能重建工程技术研究中心，副主任

2019-2021，广东省生物医学工程重点实验室，主任

2016-2020，华南理工大学生命科学研究院，教授

2006-2016，中国科学技术大学生命科学学院，教授；合肥微尺度物质科学国家实验室（筹），研究员；中科院天然免疫和慢性疾病重点实验室，副主任；中国科学技术大学医学中心，副主任

2006.06-2006.08，德国罗斯托克大学医学院，高级访问教授

2004-2006，中国科学技术大学高分子科学与工程系，教授

2002-2004，约翰霍普金斯大学医学院生物医学工程系，博士后

1999-2002，Johns Hopkins Singapore，博士后

1993-1998，武汉大学，博士，高分子化学与物理专业

1989-1993，武汉大学，学士，主修化学专业，辅修细胞生物学专业

生物医学工程（学博、学硕）、材料与化工（工程博士）、生物学（学博、学硕）、生物与医药（工程硕博）

纳米生物医学、药物递送系统、肿瘤免疫和生物治疗、mRNA疫苗

主要从事生物大分子药物、生物材料及递送系统研究，发展了肿瘤微环境响应的递送载体构建技术，研发了用于核酸药物递送的“CLAN”载体平台和用于抗体药物递送的“纳米适配子”载体技术，在Nat. Biomed.Eng.、Nat.Nanotechnol.、Sci. Transl. Med.、Nat. Commun.、Proc. Natl.Acad. Sci. U. S. A.、Angew. Chem. Int. Ed.、J. Am. Chem. Soc.、Adv. Mater.等杂志发表研究论文280余篇，被引用25700余次，H-Index 91；入选科睿唯安“高被引科学家”和爱思唯尔中国高被引学者；申请发明专利60余件，其中PCT专利9件，美国发明专利4件，授权发明专利33件，其中授权美国发明专利1件。

获国家自然科学奖二等奖、广东省科学技术奖一等奖、教育部自然科学奖一等奖、中国生物材料学会科学技术奖、第二届生物医用高分子材料大会“杰出贡献奖”、广东省学校优秀教学成果奖（高等教育一研究生类）一等奖等；主持国家重点研发计划、国家自然科学基金重点等研究项目。

担任Biomaterials副主编，Acta Biomaterialia、Journal of Controlled Release、Aggregate杂志编委；ChemNanoMat、AdvancedHealthcare Materials杂志顾问编委，《生物材料科学与工程》丛书执行副总主编，《中国卫生标准管理》杂志社第一届药品监管科学与现代药事管理编委会副主编，中国生物材料学会常务理事，中国生物材料学会智能仿生生物材料分会主任委员，中美纳米医学与纳米生物技术学会创会委员等。

代表性论文列表：

1.Ya-Nan Fan, LongZhu, Yu-Xin Qing, Si-Yi Ye, Qian-Ni Ye, Xiao-Yi Huang, Dong-Kun Zhao, Tai-YuTian, Fang-Chao Li, Guan-Rong Yan, Xian-Zhu Yang, Song Shen*, Jun Wang*, Engineering Multi-SpecificNano-Antibodies for Cancer Immunotherapy, Nature Biomedical Engineering, 2025 9, 2124–2140

2.Shi-Kun Zhou#,Jing-Tong Luo#, Yi-Fang Chen, Zi-Dong Lu, Qiu-Hong Jian, Shui-QingJiang, Jing Li, Xue-Qin Zhang, Xin-Yu Tan, Xian-Zhu Yang, Cong-Fei Xu*, JunWang*, Muscle-specific Gene Editing Therapy via Mammalian Fusogen-DirectedVirus-Like Particles, NatureCommunications, 2025, 16, 9145.

3.Yue Wang#,Min Yang#, Bao-Yue Zhang, Gui Zhao, Shi-Kun Zhou, Zi-Dong Lu,Cong-Fei Xu*, Jun Wang*, Leveraging T-Cell-Specific Fusogenicity of HIVfor invivo mRNA Delivery to Produce Human CAR-T Cells, Cell Biomaterials, 2025, 1, 100011

4.Yueqiang Zhu,Chaoran Chen, Junbin Chen, Miao Su, Wanling Huang, Sichen Liu, Mingda Yang, ChengqiongMao, Song Shen*, Xianzhu Yang*, JunWang*, In Vivo Generation and Manipulation of CAR-T-mimicking Cells viaMagnetic Bispecific Nano-antibody for Solid Tumor Therapy, Advanced Materials, 2026, 10.1002/adma.202520493

5.Qian-Ni Ye, LongZhu, Jie Liang, Dong-Kun Zhao, Tai-Yu Tian, Ya-Nan Fan, Si-Yi Ye, Hua Liu,Xiao-Yi Haung, Zhi-Ting Cao, Song Shen*, Jun Wang*, Orchestrating NK and T cells via tri-specific nano-antibodies forsynergistic antitumor immunity, Nature Communications, 2024, 15, 6211

6.Gui Zhao#, Yue Zhang#, Cong-Fei Xu*, Jun Wang*, In Vivo Production of CAR-T Cells Using Virus-mimetic FusogenicNanovesicles, Science Bulletin, 2024, 69, 354-366

7.Yansong Dong#,Ye Liu#, Yalan Tu, Youyong Yuan*, Jun Wang*, AIEgens Cross-linked Iron Oxide Nanoparticles Synchronously AmplifyBimodal Imaging Signals in Situ by Tumor Acidity-Mediated Click Reaction, Angewandte Chemie International Edition, 2023, 62, e202310975

8.Yue Wang#,Shi-Kun Zhou#, Yan Wang, Zi-Dong Lu, Yue Zhang, Cong-Fei Xu*, Jun Wang*, Engineering Tumor-SpecificGene Nanomedicine to Recruit and Activate T Cells for Enhanced Immunotherapy, Nature Communications, 2023, 14, 1993

9.Mingdong Liu#, Liangqi Huang#, Weinan Zhang#,Xiaochuan Wang, Yuanyuan Geng, Yuhao Zhang, Li Wang, Wenbin Zhang, Yun-JiaoZhang, Shiyan Xiao*, Yan Bao*, Menghua Xiong*, Jun Wang*, ATransistor-Like pH-Sensitive Nanodetergent for Selective Cancer Therapy, Nature Nanotechnology, 2022, 17, 541-551

10.Shasha He#, Jing Liu#, Chi Zhang, Jun Wang*, Kanyi Pu*, SemiconductingPolymer Nano-regulators with Cascading Activation for Photodynamic CancerImmunotherapy, Angewandte Chemie International Edition, 2022, 61, e202116669

11.Jing Liu#, Shasha He#, Yingli Luo, Yue Zhang,Xiaojiao Du, Cheng Xu, Kanyi Pu*, Jun Wang*, Tumor-Microenvironment-Activatable Polymer Nano-Immunomodulator forPrecision Cancer Photoimmunotherapy, Advanced Materials, 2022, 34, 2106654

12.Jing Liu, Si Si Liew, Jun Wang*,Kanyi Pu*, Bioinspired and Biomimetic Delivery Platforms for Cancer Vaccines, AdvancedMaterials, 2022, 34,2103790

13. Cheng-Tao Jiang#,Kai-Ge Chen#, An Liu, Hua Huang, Ya-Nan Fan, Dong-Kun Zhao, Qian-NiYe, Hou-Bing Zhang, Cong-Fei Xu, Song Shen*, Meng-Hua Xiong, Jin-Zhi Du,Xian-Zhu Yang, Jun Wang*, ImmunomodulatingNano-Adaptors Potentiate Antibody-Based Cancer Immunotherapy, Nature Communications, 2021, 12, 1359

14.Shuya Li#, Min Li#, Shaohu Huo, QinWang, Jing Chen, Shenggang Ding, Zhutian Zeng, Wenchao Zhou, Yucai Wang*, JunWang*, Voluntary-Opsonization-Enabled Precision Nanomedicinesfor Inflammation Treatment, Advanced Materials, 2021, 33,2006160

15. Yansong Dong, Yalan Tu, Kewei Wang, Congfei Xu, YouyongYuan*, Jun Wang*, A General Strategy for Macrotheranostic Prodrug Activation: Synergybetween the Acidic Tumor Microenvironment and Bioorthogonal Chemistry, Angewandte Chemie International Edition, 2020, 59, 7168-7172

16.Jin-Zhi Du*,Hong-Jun Li, Jun Wang*, Tumor-Acidity Cleavable Maleic Acid Amide (TACMAA): A Powerful Tool forDesigning Smart Nanoparticles to Overcome Delivery Barriers in CancerNanomedicine, Accounts ofChemical Research, 2018, 51,2848-2856

17.Cong-Fei Xu#, Zi-Dong Lu#, Ying-LiLuo, Yang Liu, Zhi-Ting Cao, Song Shen, Hong-Jun Li, Jing Liu, Kai-Ge Chen,Zhi-Yao Chen, Xian-Zhu Yang, Zhen Gu,Jun Wang*, Targeting of NLRP3 Inflammasome withGene Editing for the Amelioration of Inflammatory Diseases, Nature Communications, 2018, 9, 4092

18.Hong-Jun Li#, Jin-Zhi Du#,Xiao-Jiao Du#, Cong-Fei Xu, Chun-Yang Sun, Hong-Xia Wang, Zhi-TingCao, Xian-Zhu Yang, Yan-Hua Zhu, Shu-MingNie*, Jun Wang*, Stimuli-responsive Clustered Nanoparticles for Improved Tumor Penetrationand Therapeutic Efficacy, PNAS, 2016, 113, 4164-4169

19.Chun-Yang Sun#, Yang Liu#, Jin-ZhiDu#, Zhi-Ting Cao, Cong-Fei Xu, JunWang*, Facile Generation of Tumor pH-Labile Linkage-BridgedBlock Copolymers for Chemotherapeutic Delivery, Angewandte Chemie International Edition, 2016, 128,1022-1026

20.Chun-Yang Sun#, Song Shen#,Cong-Fei Xu, Hong-Jun Li, Yang Liu, Zhi-Ting Cao, Xian-Zhu Yang, Jin-Xing Xia, Jun Wang*, TumorAcidity-Sensitive Polymeric Vector for Active Targeted siRNA Delivery, Journal of the American Chemical Society, 2015, 137, 15217–15224

21.Xian-Zhu Yang#, Xiao-Jiao Du#, YangLiu, Yan-Hua Zhu, Yang-Zhong Liu, Ya-Ping Li, Jun Wang*, Rational Design of Polyion ComplexNanoparticles to Overcome Cisplatin Resistance in Cancer Therapy, Advanced Materials, 2014, 26, 931-936

22.You-Yong Yuan#, Chen-Qiong Mao#,Xiao-Jiao Du, Jin-Zhi Du, Feng Wang, JunWang*, Surface Charge Switchable Nanoparticles based onZwitterionic Polymer for Enhanced Drug Delivery to Tumor, Advanced Materials, 2012, 24, 5476-5480

23.Yuan-Zeng Min, Cheng-Qiong Mao, Si-Ming Chen, Guo-Lin Ma,Jun Wang*, Yang-Zhong Liu*, Combating theDrug Resistance of Cisplatin Using a Platinum Prodrug Based Delivery System, Angewandte Chemie-International Edition, 2012, 51, 6742-6747

24.Yan-Dan Yao#, Tian-Meng Sun#,Song-Yin Huang, Shuang Dou, Ling Lin, Jia-Ning Chen, Jian-Bin Ruan, Cheng-QiongMao, Feng-Yan Yu, Mu-Sheng Zeng, Jian-Ye Zang, Qiang Liu, Feng-Xi Su, PeterZhang, Judy Lieberman*, Jun Wang*,Erwei Song*, Targeted Delivery of PLK1-siRNA by ScFv Suppresses Her2+Breast Cancer Growth and Metastasis, Science Translational Medicine, 2012, 4, 130ra48

25.Meng-Hua Xiong#, Yan Bao#, Xian-ZhuYang, Yu-Cai Wang, Bao-Lin Sun*, JunWang*, Lipase-Sensitive Polymeric Triple-Layered Nanogel for“On-Demand” Drug Delivery, Journal of the American Chemical Society, 2012, 134, 4355-4362

论文详细列表：http://www.researcherid.com/rid/F-9033-2011