钱洁颖 博士
电子邮件: qianjieying1314@scut.edu.cn
2021-至今 华南理工大学 博士后
2017-2020 华南理工大学 生物医学工程 医学博士
2014-2017 广西医科大学 生物化学与分子生物学 硕士
2010-2014 广东医科大学 临床药学 学士
纳米材料的生物学效应及利用纳米策略调控蛋白质稳态的研究
噬菌体展示技术筛选功能短肽、肿瘤免疫调节生物材料
主要从事纳米生物效应调控蛋白质稳态及重大疾病治疗的研究。在靶向突变p53抗肿瘤的研究领域积累了相关工作基础，已开发多种具有独特生物活性的工程化纳米药物来调控突变型p53的稳定性、实现了肿瘤高效精准治疗的研究。近年来以第一（或共第一）或共通讯作者在Nature Nanotechnology、Advanced Materials、Advanced Functional Materials、Angewandte ChemieInternational Edition、Nano Today、ACS Applied Materials & Interfaces、J Nanobiotechnology等杂志发表SCI论文10篇；其中影响因子>10 7篇，申请国家发明专利7项，授权4项；主持国家自然科学基金青年基金项目、中国博士后科学基金特别资助项目、广州市科技计划项目。
(1) Jieying Qian#, Zhenyu Yang#,Wang Zhang#, YaYi Ye, Yang Song, Yingxuan Ye, Yuping Zhou, QingqiZheng, Xiaowan Huang, Sitong Du, Hao Zhang, Meng Gao, Yunjiao Zhang*, NIREmissive Functional Nanoparticles Promote Precise Pancreatic Cancer Therapy byCo-targeting Mutant p53 and Oncogenic KRAS, Advanced Functional Materials,2024. 2312610. (IF=19.0, JCR:1区).
(2) Xiaowan Huang#,Ziyang Cao#, Jieying Qian#, Tao Ding, Hao Zhang,Suqin Zhong, Xiaoli Wang, Xiaoguang Ren, Wang Zhang,Youcui Xu, Guangyu Yao, Xianzhu Yang*, Longping Wen,* & Yunjiao Zhang*,Nanoreceptors promote mutant p53 protein degradation by mimicking selectiveautophagy receptors, NatureNanotechnology. 2024 (Online, IF=38.0, JCR:1区).
(3) Xiaoli Wang#,Jieying Qian#,ZhenyuYang#, Wenping Pan, Yang Song, Yayi Ye, Xiaohua Qin, Xianwu Yan,Xiaowan Huang, Li Yan, Jieying Qian*, Meng Gao*, Yunjiao Zhang*, Photodynamic Modulation of Endoplasmic Reticulum andMitochondria Network Boost Cancer Immunotherapy, Advanced Materials,2023, e2310964. (IF=29.4, JCR:1区).
(4) Yang Song#,Zhenyu Yang#, Xiaoli Wang, Yayi Ye, Xianwu Yan, Yubing Huang,Xiaowan Huang, Hao Zhang, Jieying Qian*, Yunjiao Zhang *, Harnessing a triphenylphosphine-based AIE nano-platform fortriggering incomplete mitophagy to continuously augment anti-tumor immuneresponse in hepatocellular carcinoma, Nano Today,2023,102090, 1748-0132. (IF=17.4, JCR:1区)
(5) Jieying Qian#, Wenbin Zhang#, Pengfei Wei#,Guangyu Yao*, Tianxiang Yi, Hao Zhang, He Ding, Xiaowan Huang, Meimei Wang,Yang Song, Suqin Zhong, Lijiao Yang, Jinhao Gao, Zijian Zhou, Longping Wen* andYunjiao Zhang*. Enhancing Chemotherapy of p53-Mutated Cancer throughUbiquitination-Dependent Proteasomal Degradation of Mutant p53 Proteins byEngineered ZnFe-4 Nanoparticles. Advanced Functional Materials,2020, 30,2001994 (IF=19.0, JCR:1区).
(6) Zikai Zhou#, Jieying Qian#, Kai Liu*, YunjiaoZhang*, Meng Gao*, Ben Zhong Tang*, A Water-Stable and Red-Emissive RadicalCation for Mutp53 Cancer Therapy, Angewandte Chemie International Edition,2022,61(46):e202212671 (IF=16.6, JCR:1区).
(7)Tianxiang Yi#, Jieying Qian#*, Yayi Ye, Hao Zhang,Xin Jin, Meimei Wang, Zhenyu Yang, Wang Zhang, Longping Wen*, Yunjiao Zhang*,Crizotinib Nanomicelles Synergize with Chemotherapy through InducingProteasomal Degradation of Mutp53 Proteins. ACS Applied Materials &Interfaces, 2023, 15(1):511-523.(IF=9.5, JCR:1区).
(8) Hao Zhang, Wang Zhang, Bochuan Hu, Xiaohua Qin, Tianxiang Yi, Yayi Ye,Xiaowan Huang, Yang Song, Zhenyu Yang, Jieying Qian*, Yunjiao Zhang*, Precise pancreatic cancer therapy through targeteddegradation of mutant p53 protein by cerium oxide nanoparticles, JNanobiotechnology, 2023, 21(1):117.(IF=10.2, JCR:1区).