Name：Ling Wang
E-mail：lingwang@scut.edu.cn
Education and working experience
2014.07 Sun Yat-sen University PHD in medicinal chemistry
2016.10 South China University of Technology Postdoctoral research
2016.11 South China University of Technology Lecturer
2017.01 South China University of Technology Associate researcher
Major research interests
Drug design、Medicinal chemistry、Chemical biology、Bioinformatics
1. Developing new methodologies for drug design and bioinformatics
2. Design, synthesis, biological evaluation of new anticancer agents targeting mTOR kinase or Tubulin
3. D Drug repositioning database (DRD) and algorithm
Selected Recent Publications（*Corresponding author）
1.Luo Yao and Ling Wang*.Discovery and development of ATP-Competitive mTOR inhibitors using computational approaches. Current Pharmaceutical Design, 2017, In press. (invited review paper).
2.Jinling Shang, Xi Dai, Yecheng Li, Marco Pistolozzi and Ling Wang*. HybridSim-VS: a web server for large-scale ligand-based virtual screening using hybrid similarity recognition techniques. Bioinformatics2017,In press.
3.Ling Wang*, Xiaoqian Pang, Yecheng Li, Ziying Zhang, and Wen Tan*. RADER: a RApid DEcoy Retriever to facilitate decoy based assessment of virtual screening. Bioinformatics2017,1-3.
4.Ling Wang*, Yu Wang, Yiguang Tian, Jinling Shang, Xiaoou Sun, Hongzhuan Chen, Hao Wang*, Wen Tan*. Design, synthesis, biological evaluation, and molecular modeling studies of chalcone-rivastigmine hybrids as cholinesterase inhibitors. Bioorg. Med. Chem. 2017, 25, 360–371.
5.Ling Wang, Lei Chen, Miao Yu, Li-Hui Xu, Bao Cheng, Yong-Sheng Lin, Qiong Gu, Xian-Hui He* and Jun Xu*. Discovering new mTOR inhibitors for cancer treatment through virtual screening methods and in vitro assays. Sci. Rep.2016, 6, 18987; doi: 10.1038/srep18987.
6.Ling Wang, Yecheng Li, Mengyan Xu, Xiaoqian Pang, Zhihong Liu, Wen Tan* and Jun Xu*. Chemical fragments-based CDK4/6 inhibitors prediction and web server. RSC Adv., 2016, 6, 16972–16981.
7.Ling Wang*, Ranran Zeng, Xiaoqian Pang, Qiong Gu* and Wen Tan*. The Mechanisms of Flavonoids Inhibiting Conformational Transition of Amyloid-β42 Monomer: A Comparative Molecular Dynamics Simulation Study. RSC Adv., 2015, 5, 66391–66402.
8.Ling Wang, Xiu Le, Long Li, Yingchen Ju, Zhongxiang Lin, Qiong Gu and Jun Xu*. Discovering New Agents Active against Methicillin-resistant Staphylococcus aureus with Ligand-based Approaches. J. Chem. Inf. Model.2014, 54 (11), 3186–3197.
9.Ling Wang, Lei Chen, Zhihong Liu, Minghao Zheng, Qiong Gu and Jun Xu*. Predicting mTOR Inhibitors with a Classifier Using Recursive Partitioning and Naïve Bayesian Approaches. Plos One2014, 9(5): e95221.
10.Ling Wang, Qiong Gu*, Xuehua Zheng, Jiming Ye, Zhihong Liu, Jiabo Li, Xiaopeng Hu, Arnold T. Hagler*, and Jun Xu*. Discovery of New Selective Human Aldose Reductase Inhibitors through Virtual Screening Multiple Binding Pocket Conformation. J. Chem. Inf. Model.2013, 53, 2409-2422.
