Xiaozhong Shi

Degree: Ph.D

Title: Professor

Research area: transcriptional regulation of gene expression

Email: xiaozhongshi@scut.edu.cn

Education:

1997: B.S., Xiamen University; Major: biochemistry;

2002: Ph.D, Shanghai Institutes of Biological Sciences, CAS; Major: Biochemistry and molecular biology

Work Experience:

I had my postdoctoral training in UT Southwestern Medical Center at Dallas after Ph.D graduation in 2002, and then was recruited to the Medical School at the University of Minnesota as an Assistant Professor in 2007. I have joined the faculty member in the School of Bioscience and Bioengineering at the South China University of Technology in 2016.

Research:

My research is related to the transcriptional regulation of gene expression, with the primary interest in the regulatory mechanisms during skeletal muscle differentiation. A variety of techniques have been employed to examine the mechanisms governing gene expression: biochemistry, molecular biology, cell biology, gene targeting, transgenic animal, and in vitro culture of embryonic stem cell.

Publication:

(1) Wuming Gong, Rachel M Gohla, Kathy M Bowlin, Naoko Koyano-Nakagawa, Daniel J Garry, Xiaozhong Shi*. Kelch repeat and BTB domain-containing protein 5 (Kbtbd5) regulates skeletal muscle myogenesis through the E2F1-DP1 complex. J Biol Chem, 2015, 290(24):15350-15361.

(2) Kathy MBowlin, Laurence J Embree, Mary G Garry, Daniel J Garry, Xiaozhong Shi*. Kbtbd5 is regulated by MyoD and restricted to the myogenic lineage.  Differentiation. 2013，86(4-5):184-191.

(3) Xiaozhong Shi, Jai Richard, Katie M Zirbes, Wuming Gong, Gufa Lin, Michael Kyba, Jamie A Thomson, Naoko Koyano-Nakagawa, Daniel J Garry. Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages.  Dev Biol. 2014, 389(2):208-218;

(4) Sunny S Chan, Xiaozhong Shi, Akira Toyama, Robert W Arpke, Abhijit Dandapat, Michelina Iacovino, Jin-Joo Kang, Gengyun Le, Hannah R Hagen, Daniel J Garry, Michael Kyba. Mesp1 Patterns Mesoderm into Cardiac, Hematopoietic, or Skeletal Myogenic Progenitors in a Context-Dependent Manner, Cell Stem Cell, 2013: 12, 587-601.

(5) Xiaozhong Shi, Alicia M Wallis, Robert D Gerard, Kevin A Voelker, Robert W Grange, Ronald A Depinho, Mary G Garry, Daniel J Garry. Foxk1 promotes muscle stem cell proliferation by repressing Foxo4 and Mef2c factors. Journal of Cell Science, 2012, 125:5329-5337;

(6) Xiaozhong Shi, David C Seldin, Daniel Garry. Foxk1 recruits the Sds3 complex and represses gene expression in myogenic progenitors. Biochemical Journal, 2012, 446, 349-357.