hldu@scut.edu.cn
39380667
Education and work experience
1995.9-1999.7: Bachelor degree, South China Agricultural University
1999.9-2002.7: Master degree, South China Agricultural University
2002.9-2005.7: Doctor degree, South China Agricultural University
2006.1-2009.8: lecturer at South China University of Technology
2009.9-2015.8: Associate Professor, South China University of Technology
2015.8- so far: Professor at South China University of Technology
Research interests and key performance
Research interests: (1) Researches for potential biomarkers and targets of major diseases: A mass of omics data were accumulated along with the rapid development of omics science and technology. We are focusing on revealing the pathogenesis of this disease from all levels using the method of interdisciplinary thinking and systems biology, and identifying potential biomarkers and targets of T2D and cancer at present. (2) The application of high-throughput genomic technology in disease prediction and prevention: Some prospective studies on the prediction and prevention of major geriatric diseases and tumors.
Key performance: Chaired or participated in more than 20 of the Major Projects and Technology Support projects. Published more than 30 papers at Nat Biotechnol, Sci Rep, PloS One and other international SCI magazine, the total impact factor was 151.14, the total cited was 503 times. Applied for 6 patents.
Representative research projects
1.Participated in the National 863 Project: Research, Development of integrated software for the prediction of SNPs effects on drug metabolizing. (2008-2011) 150 thousand
2.Chaired the Guangdong Sience and Technology Project: Establishment of a gene library and a MHC allele information library for immune and disease related genes in cynomolgus monkeys (2010-2012) 150 thousand
3.Chaired the Basic Research Project of the Central University of South China University of Technology: The genetic markers of type 2 diabetes mellitus model of the cynomolgus monkey (2011-2012) 200 thousand
4.Participated in the 125 Major Projects (deputy head): Primate model resource platform construction for human major diseases (2011-2013) 1 million 120 thousand
5.Chaired the Innovation Fund for SCUT-BGI: The molecular mechanism and therapy target screening in the pathogenesis of type 2 diabetes mellitus (2013-2015) 230 thousand
6.Chaired the National Natural Science Foundation of China: Study on the molecular mechanism of the pathogenesis of type 2 diabetes mellitus in cynomolgus monkey (2014) 150 thousand
7.Participated in the National Natural Science key Fund: Key problems of biogeochemical cycle in metal mining area (2014-2018) 250 thousand
8.Participated in the Scientific and Technological Support Project: Research and demonstration of primate model of human important disease (2014-2016) 250 thousand
9.Participated in the Scientific and Technological Support Project: New techniques, methods research and application for MFIA, PCR-HRM, gene chip detection and diagnosis of infectious diseases, and SNP detection of genetic quality of laboratory animals, (2015-2017) 1 million 100 thousand
10.Chaired Major projects in Guangzhou: Prediction, prevention of major chronic non communicable diseases based on SNP chip technology and popularization (2015-2017): 1 million
Representative papers
1.Li Y, Zheng H, Luo R, Wu H, Zhu H, Li R, Cao H, Wu B, Huang S, Shao H, Ma H,Zhang F, Feng S, Zhang W, Du H, Tian G, Li J, Zhang X, Li S, Bolund L,Kristiansen K, de Smith AJ, Blakemore AI, Coin LJ, Yang H, Wang J, Wang J. Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de novo assembly. Nature Biotechnology. 2011,29(8):723-730（SCI IF=31.1）
2.Yan G, Zhang G, Fang X, Zhang Y, Li C, Ling F, Cooper DN, Li Q, Li Y, van Gool AJ, Du H, Chen J, Chen R, Zhang P, Huang Z, Thompson JR, Meng Y, Bai Y, Wang J, Zhuo M, Wang T, Huang Y, Wei L, Li J, Wang Z, Hu H, Yang P, Le L, Stenson PD, Li B, Liu X, Ball EV, An N, Huang Q, Zhang Y, Fan W, Zhang X, Li Y, Wang W, Katze MG, Su B, Nielsen R, Yang H, Wang J, Wang X, Wang J. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques.Nature Biotechnology. 2011, 29(11):1019-23.（SCI IF=31.1）
3.Meng Y, et al. RNA-seq analysis of the hypothalamic transcriptome reveals the networks regulating physiopathological progress in the diabetic GK rat. Scientific Reports. 2016, 6:34138. doi: 10.1038/srep34138. Corresponding author （SCI IF=5.3）
4.Zhang X, Meng Y, Houghton P, Liu M, Kanthaswamy S, Oldt R, Ng J, Trask JS,Huang R, Singh B, Du H, Smith DG. Ancestry, Plasmodium cynomolgi prevalence and rhesus macaque admixture in cynomolgus macaques (Macaca fascicularis) bred for export in Chinese breeding farms. J Med Primatol. 2017, 46(2):31-41. Corresponding author
5.Jin X, He M, Ferguson B, Meng Y, Ouyang L, Ren J, Mailund T, Sun F, Sun L, Shen J, Zhuo M, Song L, Wang J, Ling F, Zhu Y, Hvilsom C, Siegismund H, Liu X, Gong Z, Ji F, Wang X, Liu B, Zhang Y, Hou J, Wang J, Zhao H, Wang Y, Fang X, Zhang G, Wang J, Zhang X, Schierup MH, Du H, Wang J, Wang X. An effort to use human-based exome capture methods to analyze chimpanzee and macaque exomes. PLoS One. 2012;7(7):e40637. Corresponding author （SCI IF=4.0）
6.Chen J, Meng Y, Zhou J, Zhuo M, Ling F, Zhang Y, Du H, Wang X. Identifying candidate genes for Type 2 Diabetes Mellitus and obesity through gene expression profiling in multiple tissues or cells. J Diabetes Res. 2013, 2013:970435. doi:10.1155/2013/970435. Corresponding author （SCI IF=3.5）
7.Zhou J et al. Comparative MicroRNA Expression Profiles of Cynomolgus Monkeys, Rat and Human Reveal miR-182Involved in T2D Pathogenic Processes. J Diabetes Res.2014, 2014: 760397Corresponding author（SCI IF=3.5）
8.Wang Y, et al. Identifying Human Genome-wide CNV, LOH and UPD by Targeted Sequencing of Selected Regions. PLoS One. 2015, 10(4):e0123081 Corresponding author
9.Meng Y, et al. Genome-wide Analysis of Positively Selected Genes in Seasonal and Non-seasonal Breeding Species. PLoS One. 2015, 10(5):e0126736 Corresponding author
10.Chen B, et al. A Genome-Wide mRNA Screen and Functional Analysis Reveal FOXO3 as a Candidate Gene for Chicken Growth. PLoS One. 2015, 10(9):e0137087. Corresponding author
Others (Invention patents and software copyrights)
1.patent 201510828517.4, A method of screening susceptibility SNP combination of complex disease based on susceptibility SNP (The first inventor)
2.patent 201510828705.7, A method of rapid screening of disease candidate markers or targets (The first inventor)
3.Licensed Patents 2009SR056211, neural network based drug metabolism prediction software (V1.0 version), 2009, People's Republic of China national copyright administration computer software copyright registration
4.Apply for software copyright: Screening software for disease diagnosis markers or therapeutic target combinations
