美国罗德岛大学药学院Hang Ma助理教授学术报告

报告题目：Development of A Platform to Identify Molecular Target(s) of Small Molecules Based Therapeutics with Proteomics and Biophysical Binding Techniques

报告人：Hang Ma 助理教授，美国罗德岛大学

报告时间：2024年12月04日（星期三）上午9：00-11：30

报告地点：华南理工大学食品科学与工程学院13号楼东糖厅

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食品科学与工程学院

2024年12月3日

内容摘要：

A platform using acombination of proteomics (with data obtained from in vivo and in vitro models)and surface plasmon resonance (SPR) binding assays were developed to facilitatethe identification of the molecular targets that are responsible for the biological effects of small molecules. For instance, we utilized this platform to uncover the anti-inflammatory mechanisms of phenolic-enriched maple syrupextract in LPS-indued peritonitis in mice using data-independent acquisitionproteomics analysis. In addition, the SPR technique was used to screen alibrary of natural products and FDA-approved drug chemicals for specificblockade effects on the interactions of immune checkpoints includingPD-1/PD-L1.

报告人简介：

Hang Ma, Ph.D., is an Assistant Professor in the Department of Biomedical and Pharmaceutical Sciences at the College ofPharmacy of the University of Rhode Island (URI). He is the Director of the Bioactive Botanical Research Laboratory (BBRL) and the Head of the Research Unit for Nutraceutical and Cosmeceutical Applications (RUNCA) at URI. Dr. Ma received his Master's and Doctoral degrees in Pharmaceutical Sciences in 2011 and 2015 from URI, respectively. Dr. Ma has over 15 years of research experience in natural product chemistry. His research interests include the phytochemical and biological investigations of natural products from medicinalplants and functional foods for their nutraceutical and cosmeceutical applications. Dr. Ma has co-authored over 110 original peer-reviewed researcharticles, 4 review articles, and 1 international patent on novel botanical extracts for cosmetics.