阮志

阮志，博士，教授，博士生导师。2006至2010年就读于中山大学药学专业，获学士学位。2010至2015年在中国科学院上海药物研究所学习药理学，获博士学位。先后在美国德克萨斯大学西南医学研究中心、波士顿大学、梅奥诊所担任博士后、副研究员，并在国际知名制药公司阿尔凯默斯担任资深研究员，从事神经系统疾病原创新药的研发工作。2023年11月加入华南理工大学食品科学与工程学院。       本课题组主要关注脑衰老过程中脑内细胞功能衰退的物质基础，结合基因测序、蛋白质组学、营养物质鉴定以及脑细胞功能分析的研究策略，围绕健康脑细胞所需的营养成分及功能性食品开发领域开展深入交叉学科研究，从而为改善脑细胞功能及保护大脑健康提供精准的干预措施以及营养物质。此外，课题组关注小胶质细胞在维持中枢神经系统稳态中的相关机理以及干细胞来源的外泌体精准营养价值研究。主要研究成果已发表在Brain, Alzheimer's & Dementia, Molecular Neurodegeneration, Molecular Psychiatry, Cell Reports , 和Cellular and Molecular Life Sciences等国际著名刊物上，并多次受邀在国际学术会议作大会报告，包括Cold Spring Harbor Laboratory Conference，ISEV2021，AD/PD2022等。长期受邀担任多家国际学术期刊的审稿人，包括Alzheimer’s & Dementia, Brain, Ageing Research Reviews, Molecular Therapy, Alzheimer's Research and Therapy, Nutrient等超过15家学术期刊。

1.脑衰老中脂质代谢的特征；

2.小胶质细胞与衰老的关系；

3.小胶质细胞与神经免疫；

4.干细胞与神经再生研究；

5.外泌体的生物学功能与应用；

6.大脑营养成分与功能性食品开发。

1.Zhi Ruan, Kayo Takamatsu-Yukawa, Yuzhi Wang, Margaret L. Ushman, Adam Thomas Labadorf, Maria Ericsson, Seiko Ikezu, Tsuneya Ikezu*. Functional genome-wide short-hairpin RNA library screening identifies key molecules for extracellular vesicle secretion from microglia. Cell reports, 2022 May 10;39(6):110791.

2.Zhi Ruan, Dhruba Pathak, Srinidhi Venkatesan Kalavai , Asuka Yoshii-Kitahara, Satoshi Muraoka, Nemil Bhatt，  Kayo Takamatsu-Yukawa, Jianqiao Hu, Yuzhi Wang, Samuel Hersh, Maria Ericsson, Santhi Gorantla, Howard E Gendelman, Rakez Kayed, Seiko Ikezu, Jennifer I Luebke , Tsuneya Ikezu*. Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons. Brain, 2021 Feb 12;144(1):288-309.

3.Zhi Ruan#, Qing Lv#, Jennifer E. Wang#, Mi Zhou; Shuiqiao Liu; Hongxia Zhang; Akshay Durvasula; Yijie Wang; Yanan Wang; Weibo Luo; Yingfei Wang*. MIF promotes neurodegeneration and cell death via its nuclease activity following traumatic brain injury. Cellular and Molecular Life Sciences, 2021 Dec 18. PMID: 34921640.

4.Zhi Ruan, Jean Christophe Delpech, Alicia Van Enoo, Jianqiao Hu, Seiko Ikezu, Tsuneya Ikezu*. P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice. Molecular neurodegeneration, 2020 Aug 18;15(1):47.

5.Zhi Ruan*. Extracellular vesicles drive Tau spreading in Alzheimer’s disease, Neural Regeneration Research, 2022 Feb;17(2):328-329.

6.Satoshi Muraoka, Annina M DeLeo, Manveen Sethi, Kayo Yukawa-Takamatsu, Zijian Yang, Jina Ko, John D. Hogan, Zhi Ruan, Yang You, Yuzhi Wang, Maria Medalla, Seiko Ikezu, Mei Chen, Weiming Xia, Santhi Gorantla, Howard E. Gendelman, David Issadore, Joseph Zaia, Tsuneya Ikezu*. Proteomic Profiling and Biological Characterization of Extracellular Vesicles Isolated from Human Alzheimer’s Disease Brain Tissues. Alzheimer's & Dementia, 2020 Jun;16(6): 896-907.

7.Shuiqiao Liu, Mi Zhou, Zhi Ruan, Yanan Wang, Calvin Chang, Masayuki Sasaki, Veena Rajaram, Andrew Lemoff, Kalyani Nambiar, Jennifer E. Wang, Kimmo J. Hatanpaa, Weibo Luo, Ted M. Dawson, Valina L. Dawson*, Yingfei Wang*. AIF3 splicing switch triggers neurodegeneration, Molecular neurodegeneration, 2021 Apr 14; 16(1):25.

8.Seiko Ikezu, Hana Yeh, Jean Christophe Delpech, Maya E. Woodbury, Alicia A. Van Enoo, Zhi Ruan, Sudhir Sivakumaran, Yang You, Carl Holland, Teresa Guillamon-Vivancos, Asuka Yoshii-Kitahara, Mina B Botros, Charlotte Madore, Pin-Hao Chao, Ankita Desani, Solaiappan Manimaran, Srinidhi Venkatesan Kalavai, W Evan Johnson, Oleg Butovsky, Maria Medalla, Jennifer I Luebke, Tsuneya Ikezu*. Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities. Molecular Psychiatry, 2020 Feb 18;10.1038/s41380-020-0671-2.

9.Xia Liu#, Zhi Ruan#, Xing-cheng Shao#, Hong-Xuan Feng, Lei Wu, Wei Wang, Hong-Min Wang, Hong-Yan Mu, Ru-Jun Zhang, Wei-Min Zhao*, Hai-Yan Zhang*, Nai-Xia Zhang*. Protective effects of B-CA on the cerebral cortex of ischemic rats revealed by a NMR-based metabolomics analysis. Neurochemical Research, 2021 Jan 3. PMID: 33389470.

10.Zhi Ruan, Tsuneya Ikezu*. Tau Secretion. In: Takashima A., Wolozin B., Buee L. (eds) Tau Biology. Advances in Experimental Medicine and Biology, 2019  vol. 1184. Springer.