陈文，博士，教授，博士生导师。曾师从陈章良，提前1年从中国农业大学获得本科学位，后加入美国仁斯利尔理工学院并于2012年获得博士学位。陈文博士拥有在默克药厂和Flagship Pioneering投资公司的工作经历，并先后在汉密尔顿学院、哈佛医学院担任博士后、特聘科学家和研究员，2021年加入华南理工大学食品科学与工程学院。独立主持并完成美国Health Assistance Foundation支持的艾尔兹海默症相关项目1项，共同主持并完成多项美国国家卫生院（NIH）课题。目前主持包括基金委面上项目、科技部重点研发、广东省基金委面上项目等多个课题。

近年来，在大量的核磁共振和蛋白质工程的基础上，陈文博士以生物膜蛋白质为研究对象，结合纳米技术，发明了新型脂质体复合物的组装方法，并以此为基础优化抗体和小分子的体外筛选；同时发展了核酸适体的筛选平台，并完善了大分子和小分子的检测体系。多次在Nature、Cell、Nature Protocols、Nature Communications、Angew Chem、JACS等顶级期刊发表论文，拥有重要专利，受到美国农业部和美国垦务局的嘉奖。并获得过哈佛医学院华人生命科学杰出科研奖和中华海外磁共振协会年度科学家奖。长期受邀担任多家知名国际学术期刊的审稿人，包括JACS 、Medicinal Chemistry 、Bioinformatics、Journal of Neurochemistry、Journal of Lipid Research、Plos Computational Bilogy、International Journal of Molecular Sciences、 Journal of Biophysics、Applied Microbiology and Biotechnology、Biochemistry、Plos One、Journal of Theoretical Biology等超过15家学术期刊。

（1）国家基金委，面上项目，32371259，乙烯受体激活与抑制分子机制研究及结构导向的抑制剂筛选，2024-01至2027-12，在研，主持

（2）中央高校重点项目，利用单向抗原呈递技术筛选葡萄糖转运蛋白拮抗抗体及抗体机理研究，2023-01至2024-12，在研，主持

（3） 科技部, 国家重点研发计划, 2022YFC2104905, DHA甘油三酯酶法制备技术及产业化示范, 2022-11 至2025-10, 490万元, 在研, 主持

（4） 广东省基础与应用基础研究基金, 广东省自然科学基金-面上项目, 2023A1515010701, 乙烯受体调控机理及分子拮抗作用研究, 2023-01 至 2025-12, 10万元, 在研, 主持

（5） 美国Health Assistance Foundation, 青年科研, A2016340S, Structural Biology of Amyloid Beta Generation, 2016-07 至 2019-06, 280万元, 结题, 主持

（6） 美国NIH, R01, 5R01GM16898, Function and Mechanism of the HCV p7 Channel and its Therapeutic Potential, 2016-07 至 2019-06, 1200万元, 结题, 参与

（7） 美国NIH, R01, 5R01A1127193, Structure-Function studies of the Membrane-Interacting Domains of HIV-1 Env Spike, 2016-02 至 2021-01, 3000万元, 结题, 参与

（8） 美国NIH, R01, 5R01HL130143, Molecular Architecture of the Mitochondrial Calcium Uniporter, 2017-02 至 2020-01, 2100万元, 结题, 参与

1. Menglei Yan, Weifei Wang, Qingqing Xu, Qian Zou, Wen Chen, Dongming Lan, Yonghua Wang. “Novel oxidation indicator films based on natural pigments and corn starch/carboxymethyl cellulose” Int. J. Biol. Macromol., Volume 253, Part 2, 2023, 126630

2. Xiaoyu Sun, Xuechen Zhao, Wen Chen, Expression, purification and micelle reconstruction of the transmembrane domain of the human amyloid precursor protein for NMR studies, 生物工程学报, 2023,39(4):1633~1643

3. Jian Li, Wen Chen, Debao Niu, Rui Wang, Fei-Yue Xu, Bo-Ru Chen, Jia-Wei Lin, Zhong-Sheng Tang, Xin-An Zeng. “Efficient and green strategy based on pulsed electric field coupled with deep eutectic solvents for recovering flavonoids and preparing flavonoid aglycones from noni-processing wastes” Journal of Cleaner Production, 2022, 368, 133019

4. Alessandro Piai, Qingshan Fu, Yongfei Cai, Fadi Ghantous, Tianshu Xiao, Md Munan Shaik, Hanqin Peng, Sophia Rits-Volloch, Wen Chen, Michael S Seaman, Bing Chen, James J Chou. “Structural basis of transmembrane coupling of the HIV-1 envelope glycoprotein” Nature Communications, 2020, 11;2317

5. Wen Chen, Bo Ouyang, James J Chou. “Critical Effect of the Detergent: Protein Ratio on the Formation of the Hepatitis C Virus p7 Channel” Biochemistry, 2019, 58 (37), 3834-3837

6. Haotian Liao, Wen Chen, Yunlu Dai, Joseph J Richardson, Junling Guo, Kefei Yuan, Yong Zeng, Kunlin Xie. “Expression of Programmed Cell Death-Ligands in Hepatocellular Carcinoma: Correlation With Immune Microenvironment and Survival Outcomes” Frontiers in oncology, 2019, 9, 883

7. Wen Chen, Junling Guo, Yongfei Cai, Bill Fu, James J Chou. “Unidirectional presentation of membrane proteins in nanoparticle-supported liposomes” Angewandte Chemie, 2019, 58, 9866-9870 (封面论文)

8. Qingshan Fu*, Alessandro Piai*, Wen Chen*, Ke Xia, James Chou. “Structure Determination Protocol for Oligomeric Transmembrane Domains” Nature Protocols, 2019, 14, 2483-2520 (共一)

9. Liqiang Pan⃰, Tianming Fu⃰, Linlin Zhao⃰, Wen Chen, Wenhui Liu, Zhijun Liu, Alessandro Piai, Qingshan FU, Shuqing Chen, Hao Wu, James J Chou. “Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling” Cell, 2019, 176 (6), 1477-1489. e14

10. Ke Li, Yunlu Dai, Wen Chen, Kang Yu, Gao Xiao, Joseph Richardson, Wen Huang, Junling Guo, Xuepin Liao, Bi Shi. “Self-Assembled Metal-Phenolic Nanoparticles for Enhanced Synergistic Combination Therapy against Colon Cancer” Advanced Biosystems, 2019,3,1800241

11. Wen Chen, Bo OuYang, James Chou. “Re-evaluating the p7 viroporin structure Reply” Nature, 2018 562, E19-E20

12. Wen Chen, Jyoti Dev, Julija Mezhyrova, Liqiang Pan, Alessandro Piai, James J Chou. “The Unusual Transmembrane Partition of the Hexameric Channel of the Hepatitis C Virus” Structure. 2018, 26(4), 627-634, e4

13. Wen Chen, Wen Zeng, Jiansen Sun, Mingcan Yang, Li li, Jingting Zhou, Yangxiao Wu, Jun Sun, Ge Liu, Rui Tang, Ju Tan, Chuhong Zhu. “Construction of an aptamer–SiRNA chimera-modified tissue-engineered blood vessel for cell-type-specific capture and delivery” ACS Nano, 2015, 9 (6), 6069-6076

14. Wen Chen, Eric Gamache, David Rosenman, Xie Jian, Lopez Marimar, Yue-Ming Li, Chunyu Wang. “Familial Alzheimer's mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site” Nature Communication. 2014 Jan 6;5:3037

15. Wen Chen, Myriam Cotton. “Expression, purification, and micelle reconstitution of Antimicrobial Piscidin 1 and Piscidin 3 for NMR studies” Protein Expr Purif. 2014 Oct, 102: 63-68.

16. David J. Rosenman, Christopher Connors, Wen Chen, Chunyu Wang, and Angel E. Garcia. “Aβ Monomers Transiently Sample Oligomer and Fibril-like Configurations: Ensemble Characterization Using a Combined MD/NMR Approach” J Mol Biol. 2013. 425 (18): p. 3338-59

17. Wen Chen, Lingyun Li, Zhenming Du, Jiajing Liu, Julie N. Reitter, Kenneth V. Mills, Robert J. Linhardt, and Chunyu Wang. “Intramolecular Disulfide Bond between Catalytic Cysteines in an Intein Precursor” J. Am. Chem. Soc., 2012, 134 (5), pp 2500–2503

18. Wen Chen, Eric Gamache, Danielle Richardson, Zhenming Du, and Chunyu Wang. “Expression, purification, and reconstitution of the transmembrane domain of the human amyloid precursor protein for NMR studies” Protein Expr Purif. 2012 Jan;81(1):11-7

19. Zhenming.Du, Jiajing Liu, Clay Albracht, Alice Hsu, Wen.Chen, Michelle D. Marieni, Kathryn M. Colelli, Jennie E. Williams, Julie N. Reitter, Keneth V. Mills, and Chunyu Wang. “Structural and Mutational Studies of a Hyperthermophilic Intein from DNA Polymerase II of Pyrococcus abyssi” J Biol Chem. 2011 Nov 4;286(44):38638-48 (封面论文)