边黎明 教授
IEEE 高级会员 Senior Membe
国际华人骨研究协会ICMRS 会员
办公电话：
电子邮件：bianlm@scut.edu.cn
教育与工作经历：
2004 年– 2009 年，美国哥伦比亚大学，生物医学工程学系，博士
2009 年– 2012 年，美国宾夕法尼亚大学，生物工程学系，博士后研究员，
2012 年– 2018年，香港中文大学, 生物医学工程学系，助理教授
2018 年– 2021年，香港中文大学, 生物医学工程学系，长聘副教授
2021 年– 今，华南理工大学, 生物医学科学与工程学院，长江学者特聘教授
研究方向：
生物材料、干细胞组织工程、水凝胶
主讲课程：
组织工程与人工器官
研究成果：
代表性论文（*通讯作者,+共一作者）
1. +Peng, X.; +Xia, X., +Xu, X.; Yang, X.; Yang, B.; Zhao, P.; Yuan, W.; *Chiu P.W.R.; *Bian, L. Ultra-fast self-gelling powder mediate robust wet adhesion to promote healing of gastrointestinal perforations. Science Advances, 2021, Vol. 7, no. 23, eabe8739
2. +Yang, B.; +Wei, K.; Loebel, C.; Zhang, K.; Feng, Q.; Li, R.; Wong, D.S.H.; Xu, X.; Lau, C.; Chen, X.; Zhao, P.; Yin, C.; Burdick, J.A.; *Wang, Y.; *Bian, L. Enhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics. Nature Communications, 2021, Article number: 3514.
3. +Wong, S.H.D.; +Xu, X.; Chen, X., Xing, Y.; Xu, L.; Lai, N.C.H.; Oh, J.; Wong, R.W.K.; Wang, X.; Han, S.; You, W., Shuai, X.; Wong, N., *Tan, Y.; *Duan, L.; *Bian, L. Manipulation of the nanoscale presentation of integrin ligand produces cancer cells with enhanced stemness and tumorigenicity. Nano Letters, 2021, 21, 7, 3225–3236.
4. +Zhao, P.; +Yang, B.; Xu, X.; Lai, N.C.H.; Li, R.; Yang, X.; *Bian, L. Nanoparticle-assembled vacuolated coacervates control macromolecule spatiotemporal distribution to provide a stable segregated cell microenvironment. Advanced Materials, 2021, 33, 9, 2007209.
5. +Xu, X.; +Xia, X.; +Zhang, K.; Rai, A.; Li, Z.; Zhao, P.; Wei, K.; Zou, L.; Yang, B.; Wong, W.K.R., *Chiu, P.W.Y.;*Bian, L. Bioadhesive hydrogels demonstrating pH-independent and ultrafast gelation promote gastric ulcer healing in pigs. Science Translational Medicine 2020, 12, 58, eaba8014.
6. Li, R.; Lin, S.; Zhu, M.; Deng, Y.; Chen, X.; Wei, K.; Xu, J.; Li, G.; *Bian, L. Synthetic presentation of noncanonical Wnt5a motif promotes mechanosensing-dependent differentiation of stem cells and regeneration. Science Advances, 2019, 5: eaaw3896.
7. Chen, X.; Li, R; Wong, S.H.D.; Wei, K.; et al.; Xia, J.; Chen, G..; L., G.; *Bian, L. Conformational manipulation of scale-up prepared single chain polymeric nanogels for multiscale regulation of cells. Nature Communications, 2019, volume 10, Article number: 2075.
8. +Kang, H.; +Yang, B.; Zhang, K.; Pan, Q.; Yuan, W.; Li, G.; *Bian, L. Immunoregulation of macrophages by dynamic ligand presentation via ligand-cation coordination. Nature Communications, 2019, volume 10, Article number: 1696.
9. +Kang, H.; + Jung, H.J.; Wong, S.H.D.; Kim, S.K.; Lin, S.; Chan, K.F.; Zhang, L.; Li, G.; Dravid, V.; *Bian, L. Remote control of heterodimeric magnetic nanoswitch regulates the adhesion and differentiation of stem cells. J. Am. Chem. Soc., 2018;140 (18): 5909-5913.
10. Bian, L.; Guvendiren, M.; Mauck, R.L.; Burdick, J.A. Hydrogels that mimic developmentally relevant matrix and N-cadherin interactions enhance MSC chondrogenesis. Proc. Natl. Acad. Sci. USA.2013 Jun 18; 110(25):10117-22.
专利
1. 美国专利: osteochondral implants, arthroplasty methods, devices and systems. Inventors: Hung C.T, Ateshian, G.A, Lima, E.G., Cook, J.L., Bian, L. Publication number: US 2010/0036492 A1)
2. 美国专利(US 9,889,086 B2)：A bioadhesive and injectable hydrogel. Inventors: Feng, Q.; Wei, K.; Lin, S.; Li, G.; Bian, L.
3. 美国专利（US 2016/0220708A1）: Nano-constructs for polynucleotide delivery. Inventors: Choi, C.K.; Choi, C.H.; Bian, L.
4. 美国、中国专利(US 2017/0204161 A1): Fast and efficient conjugation method based on thiourea–catechol coupling. Inventors: Xu, Y.; Zhao, P.; Wei, K.; Bian, L.
5. 中国专利(201711461139.6): 一种大量制备多种聚合物单链纳米颗粒的可扩展的通用方法. Inventors: Chen, X..; Wei, K.; Bian, L.
6. 美国(US20180169141)、中国专利(201711374158.5): injectable hydrogels that promote mineralization and afford sustained release of bioactive ions. Inventors: Zhang, K.; Bian, L.