Title：Stereoselective Construction of Challenging CC Bonds and the Development of Antimetastatic Agents

 Speaker：Prof. P. Andrew Evans (Queen’s University)

 Invited by：Prof. Liangbin Huang

 Time：November 18, 2026 (Wednesday), 10:00 AM – 12:00 PM

 Venue：Meeting Room 105 of the Shaw Engineering Building, Wushan Campus

 Organizer：School of Chemistry and Chemical Engineering

 Biography

 Professor P. Andrew Evans is the Alfred R. Bader Chair of Organic Chemistry and a Tier 1 Canada Research Chair in Organic and Organometallic Chemistry in the Department of Chemistry at Queen’s University. He is also a Changjiang Scholar at Central South University in China. He received a B.Sc. with honors in Applied Chemistry at Newcastle Polytechnic in 1987 and completed his Ph.D. at the University of Cambridge in 1991 under the supervision of Andrew B. Holmes, FRS. He then pursued postdoctoral research with Philip D. Magnus, FRS, at the University of Texas at Austin as a NATO Postdoctoral Fellow. In 1993, he began his independent career at the University of Delaware, where he was promoted to Professor before moving to Indiana University in 2001. In 2006, he became the Heath Harrison Chair of Organic Chemistry at the University of Liverpool before assuming his current role in 2012. His recent awards include the R. U. Lemieux Award, the Paul G. Gassman Distinguished Service Award, the Harry and Carol Mosher Award, a Changjiang Scholar Award, an ACS Cope Scholar Award and the RSC Pedler Award. He has been actively involved in the ACS Division of Organic Chemistry, serving as a MemberatLarge, Councilor, National Organic Symposium Executive Officer and Division Chair. He currently cochairs the ACSDOC Graduate Research Symposium. Professor Evans has served as an Associate Editor for Chemical Communications and Synthesis. He is also the former EditorinChief and current President of Organic Reactions. He has published nearly 175 papers, articles, reviews, book chapters and monographs and has delivered more than 500 plenary and invited lectures.

 Abstract

 The seminar will explore the development and application of new stereoselective CC bondforming reactions in the synthesis of bioactive agents. Specifically, it will highlight a novel dynamic kinetic resolution of α,βunsaturated aldehydes,[1] the catalytic asymmetric alkylation of homoenolates[2] and the development of a concise, efficient and scalable synthesis of antimetastatic agents. [3]

 References

  (1) Majhi, J.; Turnbull, B. W. H.; Ryu, H.; Park, J.; Baik,M.-H.; Evans, P. A. J. Am Chem. Soc. 2019, 141, 11770. (b) Ma, J.; Li, H.;Majhi, J.; Evans, P. A. Angew. Chem. Int. Ed. 2026, e202620674.

(2) Wright, T. B.; Turnbull, B. W. H.; Evans, P. A. Angew.Chem. Int. Ed. 2019, 58, 9886. (b) Xie, H.; Hwang, D.; Yoo, S. Y.; Ma, J.;Howe, G. W.; Baik, M.-H.; Evans, P. A. “Catalytic Stereochemical Relay for theEnantioselective Synthesis of Acyclic Quaternary Stereocenters” J. Am. Chem.Soc. 2026, 148, 40651.

(3) Bhavin V. Pipaliya, B. V.; Trofimova, D. N.;Grange, R. L.; Aeluri, M.; Deng, X.; Shah, K.; Craig, A. W.; Allingham, J. S.;Evans, P. A. J. Am. Chem. Soc. 2021, 143, 6847. (b) D. N. Trofimova, M. Aeluri,K. D. Veeranna, Y. Jiang, R. L. Grange, B. V. Pipaliya, M. Subaramanian, A. W.Craig, P. A. Evans andJ. S. Allingham, J. Med. Chem. 2024, 67, 5315.

 Announced by School of Chemistry and Chemical Engineering.