Title: Enantiospecific and Green Click Chemistry  

 Speaker: Prof. Han Zuilhof (Wageningen University)  

 Invited by: Xuefeng Xia  

 Time: October 22, 2026 (Thursday), 10:00 AM – 12:30 PM  

 Venue: Room 105 of the Shaw Engineering Building, Wushan Campus  

 Organizer: School of Chemistry and Chemical Engineering

 Abstract

 Click chemistry has revolutionized many facets of the molecular sciences, enabling modular reactions with broad substrate scope, excellent yields, stereospecificity, and minimal or benign solvents. Despite these remarkable merits, three aspects remain surprisingly underexplored: (a) the creation of inherently chiral click reactions that are enantiospecific (rather than merely enantioselective relying on chiral auxiliaries); (b) modularity, as most established click reactions resemble onedimensional LEGO bricks; and (c) stringent constraints on permissible solvents.

 This presentation focuses on our research on S(VI) exchange chemistry, with particular attention to the following directions: (a) the design of inherently enantiospecific click reactions and their applications for constructing chiral macrocycles or synthetic polymers featuring 100% backbone chirality with combined stability and degradability; (b) multimodular click chemistry and singlepolymer characterization via AFM, TEM and scanning Auger microscopy; (c) the recent development of solventfree enantiospecific click reactions.

 Biography

 Prof. Han Zuilhof holds the Chair of Organic Chemistry at Wageningen University, the Netherlands, and maintains close research collaborations with multiple universities in China, including Tianjin University and Jiaxing University. His research interests encompass surfacebound organic chemistry (controlling organic transformations at interfaces) and the development of more efficient, mild organic synthetic routes for small molecules, macrocycles, polymers and polymer brushes. In his spare time, he enjoys astronomical observation with a telescope. He appreciates all regions of China, with Guizhou as his favourite province.

 Announced by School of Chemistry and Chemical Engineering