Title:Palacký University Professor Alexander Dömling: Automation + Miniaturization = Acceleration 

Speaker: Alexander Dömling (Professor, Palacký University)   

Invited by: Professor Huang Liangbin   

Time: 10:00 a.m.–12:00 p.m., Friday, 16 January 2026   

Venue: Room 105of the Shaw Engineering Building, Wushan Campus   

Organizer: School of Chemistry and Chemical Engineering   

[Speaker biography]

 Prof Alexander Dömling (ERA Chair ofInnovative Chemistry Group at the Palacky University Olomouc) . He devotes hisacademic life to the design and discovery of bioactive compounds for difficulttargets such as protein protein interactions, transcription factors, or RNA. Hestudied multi-component reactions with Ivar Ugi at the Technical UniversityMunich (PhD), and with double Nobel laureate Barry Sharpless at The ScrippsResearch Institute (PD). At the University of Pittsburgh, he became associateand full professor and he introduced the “google-like” web-based technologyANCHOR.QUERY together with Carlos Camacho. ANCHOR.QUERY can screen very large(billions) of virtual compounds in just seconds for pharmacophores and based onkey interacting fragments, e.g. large amino acid side chains of amino acids (inPPIs). Interestingly the resulting virtual hits can be instantaneouslysynthesized using convergent and fast multicomponent reaction chemistry inorder to test the virtually generated hypothesis. From 2011 till 2022 he wasProfessor and chair of Drug Design at the University of Groningen. Anotherdevelopment is the technology platform Automated, miniaturized and accelerateddrug discovery (AMADEUS) which was recently rewarded by an ERC Advanced grant.Here a fundamentally novel approach towards preclinical drug discovery anddevelopment is introduced by blending Instant Chemistry, nL dispensing, HTpurification, HTS and machine learning. The indication areas Alexander Dömlingis interested in are cancer immunology, infectious diseases and metabolicdisorders. He has published more than 300 scientific articles, reviews andapplied for >70 patents. Additionally, Alexander Dömling is a serialentrepreneur trying to make the expression “from bench to bedside” become true.

Announced by School of Chemistry and Chemical Engineering.