Introduction:

Name:Liangbin Huang

Title: Professor

E-mail: huanglb@scut.edu.cn

Personal homepage: https://www.x-mol.com/groups/huang_liangbin

Supervisor: PhD Supervisor

Area: 

During the traditional petrochemical era， unsaturated hydrocarbon compounds (such as alkenes， alkynes， and aromatics) derived from basic petrochemical resources like coal， petroleum， and natural gas through chemical processing and refining served as fundamental raw materials for organic synthesis (Figure 1， left). The relatively low π-bond energy in these unsaturated hydrocarbons enables easy coordination and activation with metal catalysts. Their transformation chemistry has been extensively studied by organic chemists， yielding fruitful achievements that have provided abundant functional chemicals for human societal development. With the increasing depletion of petrochemical resources and the advancement of China's “Dual Carbon“ strategy， there is an urgent need to shift the primary feedstocks for organic synthesis from petrochemical-based unsaturated hydrocarbons to biomass platform molecules (Figure 1， right). This project aims to focus on developing novel and value-added transformation pathways for carboxylic acid platform molecules. It seeks to achieve rapid construction of functional carboxylic acid molecular databases and complete deoxygenation conversion of carboxylic acid molecules， while exploring high-value， precise， green， and efficient organic synthesis methods along with applications for biomass-derived carboxylic acids. The research will provide scientific support for realizing the “Dual Carbon“ objectives.The research group will employ transition-metal catalysis to design novel ligands and develop new catalytic systems， aiming to achieve three innovative reaction modes for carboxylic acids: 1) Developing new ligands to expand the scope of meta-functionalization reactions in aryl carboxylic acids; 2) Exploring efficient catalytic systems to enable divergent coupling of alkenyl carboxylic acids. Building on these advancements， the team plans to rapidly construct a functional carboxylic acid molecular database. 3) Creating a groundbreaking strategy for complete deoxygenation conversion of carboxylic acids to facilitate rapid construction of three distinct chemical bonds at the carbon center.

Education:

2018. 09 – until now Professor， South China University of Technology

2017. 08. -  2018. 09 Postdoctoral， University of Wisconsin-Madison Topic: Bimetallic CatalysisSupervisor: Prof. Daniel J. Weix

2016. 04. -  2017. 08 Postdoctoral， University of RochesterTopic: Reductive Cross CouplingSupervisor: Prof. Daniel J. Weix

2013. 08 – 2016. 03 Postdoctoral (Alexander von Humboldt Fellowship)Technische Universität Kaiserslautern， GermanyTopic: Catalytic Reactions of Carboxylic Acids with C–C- and/or C–H ActivationSupervisor: Prof. Lukas J. Gooßen

2008. 09 - 2013. 06 Ph.D， South China University of Technology， ChinaThe title of thesis: “Transition metal catalyzed oxidative functionalization of alkenes”Supervisor: Prof. Huanfeng Jiang

2004. 09 - 2008. 07 Bachelor’s Degree， Pharmaceutical EngineeringBeijing University of Chemical Technology， China

Research interests:

(1)  organic synthesis

(2)  metal catalysis

(3)  functional molecular scale up preparation

Representative publications :

(1) Xiaoyan Jia， Shuo Zhang， Yue Zeng， Zhewei Li， Ganchun Wu， Ming Lei*， Liangbin Huang*， Regiodivergent Access to alfa- and beta-Amino Acids via Solvent-Controlled Rh-Catalyzed Carboamidation of beta，garm-Unsaturated Carboxylic Acids， J. Am. Chem. Soc.， 2025， DOI: 10.1021/jacs.5c08142

(2) Zining Liu， Yandong Wang， Jiahui Liu， Huanfeng Jiang， Minyan Wang*， Liangbin Huang*， Nickel-Catalyzed Cross-Electrophile Coupling to Access Polysubstituted Cyclobutenes， Angew. Chem. Int. Ed. 2025， DOI: 10.1002/anie.202507087. (Hot Paper)

(3) Xianglin Luo， Peichao Hou， Jiayi Shen， Yifeng Kuang， Fengchao Sun， Huanfeng Jiang， Lukas J. Gooßen*， Liangbin Huang*， Ligand-Enabled Ruthenium-Catalyzed meta-C−H Alkylation of (hetero)Aromatic Carboxylic Acids， Nature Communications. 2024. 15， DOI: 10.1038/s41467-024-49362-2.

(4) Donghui Xing， Jinlin Liu， Dingxin Cai， Bin Huang， Huanfeng Jiang， Liangbin Huang*， Cobalt-Catalyzed Cross-Electrophile Coupling of Alkynyl Sulfides with Unactivated Chlorosilanes， Nature Communications. 2024. DOI: 10.1038/s41467-024-48873-2.

(5) Xiaoyan Jia， Gui-Lin Hao， Mengxia Feng， Huanfeng Jiang， Shou-Guo Wang*， Liangbin Huang*， Rh(III)-Catalyzed Diastereo- and Enantioselective Regiodivergent (Het-ero)Arylamidation of (Homo)Allylic Sulfides， J. Am. Chem. Soc. 2024. 146， 9768-9778.