Title: Construction and Application of Electrochemiluminescent Sensing Interfaces Based on Cell-Free Expression
Speaker: Professor Lin Zhenyu (Fuzhou University)
Inviter: Professor Liu Jinbin
Time: July 19, 2025 (Friday) from 9:30 AM to 12:00 PM
Venue: Conference Room 216, Building 15, School of Chemistry and Chemical Engineering
Organizing Unit: School of Chemistry and Chemical Engineering
Speaker Introduction:
Professor Lin Zhenyu is the director of the Key Laboratory of Food Safety and Bioanalysis at the Ministry of Education (Fuzhou University) and a doctoral supervisor. He graduated in 1998 from the School of Chemical Engineering and Materials, Beijing Institute of Technology, majoring in Polymer Materials and Engineering. In 2007, he obtained his Ph.D. in Analytical Chemistry from Fuzhou University. From October 2007 to March 2009, he carried out postdoctoral research in Environmental Science at Tohoku University in Japan. He has led the National Excellent Young Scientist Fund (2012) and received the Fujian Province May Fourth Youth Medal (2014), is recognized as a New Century Excellent Talent by the Ministry of Education (2012), and a Leading Talent in Science and Technology Innovation in Fujian Province (2017).
His primary research focuses on precise analysis of disease biomarkers, food processing and safety evaluation, as well as the transformation of related products. Since starting his career in 2009, he has undertaken eight projects funded by the National Natural Science Foundation and eight provincial and ministerial-level projects as the principal investigator. He holds 14 authorized national invention patents as the first inventor, has led the development and transformation of two products, and has published over 200 papers in prominent domestic and international journals, including Nat. Commun., Adv. Sci., Angew. Chem. Int. Ed., Adv. Healthc. Mater., Nano Today, and Anal. Chem.
He has received several awards, including nominations for the National Excellent Doctoral Dissertation Award, the Fujian Youth Science and Technology Award, and the Fujian Yuncheng Youth Science and Technology Award. He was awarded the Third Prize for Scientific Progress in Fujian Province (1st) in 2010, the First Prize for Natural Science in Fujian Province (5th) in 2015, the First Prize for Scientific Progress in Fujian Province (1st) in 2019, the Second Prize for Technological Invention in Hubei Province (4th) in 2020, and the Third Prize for Scientific Progress in Fujian Province (1st) in 2021. He serves as the associate editor of “Global Translational Medicine” and as a youth executive editorial board member of “Journal of Chemical Education” and “Chemical Research in Chinese Universities.”
Report Abstract:
Live cell systems are limited by the growth cycle, cell state, and production adaptability of living cells. In contrast, cell-free systems do not require maintenance of cellular life, allowing them to overcome these limitations and adapt highly to various production and testing environments, with advantages of high yield, multifunctionality, and low cost. In cell-free systems, responsive gene circuits can be designed so that when the gene circuit binds to specific targets, it triggers the transcription or translation of reporter molecules. By combining different detection technologies, highly sensitive and specific biosensors can be constructed for detecting various types of targets. Electrochemiluminescence (ECL) detection technology is characterized by its simplicity of instrumentation and high sensitivity, making it commonly used for analyzing trace or even minute target substances. Our research group has combined the advantages of cell-free expression systems with ECL detection to construct relevant biosensing interfaces for the analysis of disease biomarkers and others.
