Title: Target and Methodology-oriented Total Synthesis of Natural Products

Speaker: Prof. Jie Ping Zhu

Time: Thursday, March 6, 2025 16:00-17:00 PM

Venue: Conference Room on the Fourth Floor of the Shaw Engineering Building

[Speaker's Profile]

 Professor Jieping Zhu graduated with a Bachelor's degree from Hangzhou Normal University in 1984. He subsequently obtained his Master's degree from Lanzhou University and his Ph.D. from Université de Paris-Sud in France. From 1991 to 1992, he conducted postdoctoral research at Texas A&M University. Between 1992 and 2010, he worked independently at the Institut de Chimie des Substances Naturelles, CNRS in France. Since 2010, he has been conducting research on total synthesis,multicomponent reactions,  metal-catalyzed domino reactions, and catalytic asymmetric transformations at the Swiss Federal Institute of Technology Lausanne(EPFL). His honors include:Japan Society for the Promotion of Science(JSPS) Fellow(2002); National Science Foundation Outstanding Young Oversea Scientist Award(China)(2003); Liebig Lectureship of the German Chemical Society(2004); and the Royal Society of Chemistry(RSC)Natural Product Chemistry Award, UK(2016).

[Recent representative publications]

1) Q. Feng; Q. Wang; J. Zhu. Oxidative rearrangement of 1,1-disubstituted alkenes to ketones, Science 2023, 379, 1363.

2) Q. Feng; C. Liu; Q. Wang; J. Zhu, Palladium‐Based Dyotropic Rearrangement Enables A Triple Functionalization of Gem‐Disubstituted Alkenes: An Unusual Fluorolactonization Reaction, Angew. Chem. Int. Ed. 2024, 63, e202316393.

3) B. Yang, G. Li, Q. Wang, J. Zhu. Enantioselective Total Synthesis of (+)-Stephadiamine, J. Am. Chem. Soc. 2023, 145, 5001.

4) G. Yang, H. Wu, S. Gallarati, C. Corminboeuf, Q. Wang, J. Zhu. Migrative Carbofluorination of Saturated Amides Enabled by Pd-Based Dyotropic Rearrangement, J. Am. Chem. Soc. 2023, 144, 14047.