Title: Asymmetric Direct Transformations of Aromatic Compounds
Speaker: Researcher YOU Shuli (Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences)
Time: 10:00a.m., April 6th, 2017
Venue: Room 405, Shaw Engineering Building, Wushan Campus

Abstract: A symmetric dearomatization reactions are particularly attractive methods in organic synthesis given the facts that the starting materials arenes are highly abundant and readily available, and the dearomatization reaction would provide direct access to polycylces and spirocycles bearing quaternary stereogenic center. However, due to the extra stability of “aromaticity” of the arenes, their dearomatization reaction with good enantioselective control has been a challenge.
In this talk, the progress from the You laboratory on the development of catalytic asymmetric dearomatization processes will be introduced. Direct asymmetric dearomatization reactions of various aromatic compounds were realized with a proper choice of catalysts.

References
(1).Zhuo, C.-X.; Zheng, C.; You, S.-L. Transition-metal-catalyzed Asymmetric Allylic Dearomatization ReactionsAcc. Chem. Res.2014, 47, 2558-2573.
(2).Zhuo, C.-X.; Zhang, W.; You, S.-L.Catalytic Asymmetric Dearomatization Reactions.Angew. Chem. Int. Ed. 2012, 51, 12662-12686.
(3). You, S.-L. Asymmetric Functionalization of C–H Bonds. RSC:2015.
(4). You, S.-L. Asymmetric Dearomatization Reactions. Wiley-VCH:2016.