Name:
HuanFeng Jiang
Introduction
Huanfeng Jiang was born in Hubei province, China in 1961. He obtained his B.Sc. degree from Hubei University in 1983, M.Sc. degree from Wuhan University in 1990, and Ph.D. degree from Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences with Professor Xiyan Lu in 1993. He joined South China University of Technology as professor in 2008. His current research interests include transition metal-catalyzed organic synthetic methodologies and green chemistry. He has received a number of honors for research and teaching, including (Chinese Chemical Society)-BASF Youth Innovation Award (2002), First-Grade Guangdong Scientific and Technological Award (2010), Asian Core Program Lectureship Award Research (2014).He has published >400 peer-reviewed articles, 3 books, and has given > 60 invited lectures.His research has been cited widely in the literature > 5, 500 times.
appendix：
Key Laboratory of Functional Molecular
Engineering of Guangdong Province
Aboult the lab：
The Key Laboratory of Functional Molecular Engineering of Guangdong Province at South China University of Technology was officially operated in Dec. 2016. The mission of this key laboratory aims to reveal the relationship and laws between function, structure and synthesis at the molecular level, achieve success in a significant impact on the world scientific frontier, provide technical reserve for the relevant strategic emerging industries of Guangdong Province, and establish a key technology platform to manifest academic research level and cross disciplines, talent cultivations and academic communication, by the mean of molecular engineering and taking creation and application of new structure and special functional organic molecular system as foundation.
In basic research, the project oriented by the requirements of specific functions, design to develop the synthesis, preparation and assembly methodology of functional molecules and their systems, then study and summarize related principles and laws between function-structure-synthesis to achieve innovation on theory. The completion of this project will resolve fragmented state of functions, structures, and synthesis in traditional studies, establish the chemical and physical basis between the function, structure and synthesis, which shows great significance to improve the research level and influence of organic chemistry in Guangdong Province, especially functional organic molecules.
The implementation of the project will greatly accelerate the improvement of the independent innovation capability of the pillar industries and the new strategic industries related to the field of molecular engineering in Guangdong Province, which provide strategic and forward-looking knowledge reserves for these industries to meet the technical needs of specific industries. The contribution of pillar industries such as petrochemical, chemical pharmacy, electronic information, textile and apparel, forestry and paper making and strategic emerging industries such as biotechnology, energy saving and environmental protection, new material, new energy and semiconductor lighting to the economic development of the eastern province is self-evident. In the petrochemical industry, the chemical bond selective cleavage, environmentally friendly synthesis, catalyst construction and catalytic system screening and other series of molecular engineering related to the functional molecular engineering research will be widely used. Thus, the development of green technologies in the downstream of petrochemical industry even output high value-added new functional auxiliaries, coating monomers, electric chemicals, high polymer solvents and other products; In the biomedical industry, the advanced synthesis methodes of molecular engineering achieves the high efficiency, low cost and environmentally friendly manufacturing of target molecules, bulk pharmaceutical or pharmaceutical intermediates and new medical materials. The design and screening technologies of lead compounds, the development of innovative drugs, the treatment of local major diseases and the treatment of major infectious diseases are also inseparable from the chemical and physical basis of molecular engineering. In new materials industry, molecular engineering will functionally synthesize molecules with specific photoelectric properties and molecular aggregates as light, electricity or thermally responsive materials based on the principle of structural efficiency, while achieving its low cost and environmentally friendly manufacturing, will greatly increase the industry competitiveness.
Research Area：
1、Research on the structure and function of conjugated and agminated molecules
The research focused on molecular structure and property research of conjugated organic molecules, which reveal the general rule of relationship between structure and property of functionalized molecules. Then, investigate how to assemble to form ordered super-structure of molecular aggregator through synergistic effect, probe the context between molecular structure and the advanced structure of molecular aggregates, and applies the research results to fluorescent sensor, cell imaging, dye sensitized solar cell, biological sciences and super-molecular chemistry. From the framework of functional molecular engineering, the research is a significant part of functional-oriented constructing molecular structures-property studies, and also is the foundation of discovering new features in creating and transformating new materials.
2、Research on the biological functionalized molecules and leadsdrug molecules
This research direction focused on obtaining functional organic molecules especially heterocyclic organic molecules, developing new structures, new mechanisms and new functions, investigating the new phenomena, new effects and new laws from the interaction between molecules, life system and cellular, exploring and expanding its biological functions and properties via advanced synthetic methods, which will provide the basis for designing molecular structure and screening guidance biological molecules to make a breakthrough and high research results. This research direction will contribute to the structure-property research of new functional molecules from the perspective of the overall framework of functional organic molecular engineering.
3、Exploration of newmethods and strategies for synthesis offunctionalized molecules
This research direction mainly focuses on development new methods and new strategies with important industrial application value directing with special function (or specific structure). Carrying out this research from the molecular engineering of catalytic system, functional organic molecular precision initiative and controllable synthesis, we focus on developing several new environmental friendly catalytic systems, exploring the internal relationship and mechanism between the key reaction materials, catalysts, and reaction mediums, striving for make a breakthrough in high efficiency, low cost and environmental friendly molecular engineering and obtain some international academic achievements. This research direction is aiming to provide more possibilities and new technologies for the controlled synthesis, accurate preparation and efficiently convert of new structure molecules.
Publications：
In 2017, more than 22 research articles are indexed by SCI in the laboratory so far, and there are 25 research articles are indexed by SCI in 2016, containing 24 articles with IF>4.
2017-
1 Huang J; Li J; Zheng J; Wu W; Hu W; Ouyang L; Jiang H. Dual role of H2O2 in palladium-catalyzed dioxygenation of terminal alkenes [J]. Org. Lett.,2017, DOI: 10.1021/acs.orglett.7b01228.
2 Li J; Ren Y; Qi C; Jiang H. The first porphyrin-salen based chiral metal-organic framework for asymmetric cyanosilylation of aldehydes [J]. Chem. Commun., 2017, DOI: 10.1039/C7CC03499G.
3 Jiang H; Huang W; Yu Y; Yi S; Li J; Wu W. Transition-metal-free synthesis ofβ-trifluoromethylated enamines with trifluoromethanesulfinate [J]. Chem. Commun., 2017, DOI: 10.1039/c7cc03125d.
4 Qi C; Hu X; Jiang H. Copper-mediated C–H cyanation of (hetero)arenes with ethyl (ethoxymethylene) cyanoacetate as a cyanating agent [J]. Chem. Commun., 2017, DOI: 10.1039/c7cc03384b.
5 Wu W; An Y; Li J; Yang S; Zhu Z; Jiang H. Iodine-catalyzed cascade annulation of alkynes with sodium arylsulfinates: assembly of 3-sulfenylcoumarin and 3-sulfenylquinolinone derivatives [J]. Org. Chem. Front., 2017, DOI: 10.1039/c7cc03384b.
6 Li J; An Y; Li J; Yang S; Wu W; Jiang H. Palladium-catalyzed C-S bond activation and functionalization of 3-sulfenylindoles and related electron-rich heteroarenes [J]. Org. Chem. Front., 2017, DOI: 10.1039/c7qo00215g.
7 Guo W; Liao J; Liu, D; Li J; Ji F; Wu W; Jiang H. A four-component reaction strategy for pyrimidine carboxamide synthesis [J]. Angew.Chem. Int.Ed.,2017, 56, 1289-1293.
8 Wu W; Yi S; Huang W; Luo D; Jiang H. Ag-catalyzed oxidative cyclization reaction of 1,6-enynes and sodium sulfinate: access to sulfonylated benzofurans [J]. Org. Lett.,2017, 19, 2825-2828.
9 Peng J; Gao Y; Zhu, C; Liu, B; Gao, Y; Hu M; Wu W; Jiang H. Synthesis of polysubstituted 3‑amino pyrroles via palladium-catalyzed multicomponent reaction [J]. J. Org. Chem.,2017, 82, 3581-3588.
10 Zhu,Z; Tang X; Li J; Li X; Wu W; Deng G; Jiang H. Iron-catalyzed synthesis of 2H-imidazoles from oxime acetates and vinyl azides under redox-neutral conditions [J]. Org. Lett.,2017, 19, 1370-1373.
11 Liao J; Fan L; Guo W; Zhang Z; Li J; Zhu C; Ren Y; Wu W; Jiang H. Palladium-catalyzed fluoroalkylative cyclization of olefins [J]. Org. Lett.,2017, 19, 1008-1011.
12 Hu W; Li J; Xu Y; Li J; Wu W; Liu H; Jiang H. Palladium-catalyzed redox-neutral N−O/C(sp3)−H functionalization of aryl oximes with isocyanides [J]. Org. Lett.,2017, 19, 678-681.
13 Wang X; Huang Y; Xu Y; Tang X; Wu W; Jiang H. Palladium-catalyzed denitrogenative synthesis of aryl ketones from arylhydrazines and nitriles using O2 as sole oxidant [J]. J. Org. Chem.,2017, 82, 2211-2218.
14 Wu W; Yi S; Yu Y; Huang W; Jiang H. Synthesis of sulfonylated lactones via Ag-catalyzed cascade sulfonylation/cyclization of 1,6-enynes with sodium sulfinates [J]. J. Org. Chem.,2017, 82, 1224-1230.
15 Li Z; Zheng J; Hu W; Li J; Wu W; Jiang H. Synthesis of 1,4-enyne-3-ones via palladiumcatalyzed sequential decarboxylation and carbonylation of allyl alkynoates [J]. Org. Chem. Front., 2017, 4, 1363-1366.
16 Li J; Ren Y; Qi C; Jiang H. A chiral salen-based MOF catalytic material withhigh thermal, aqueous and chemical stabilities [J]. Dalton Trans., 2017, 46, 7821-7832.
17 Guo W; Liu D; Liao J; Ji F; Wu W; Jiang H. Cu-Catalyzed intermolecular [3 + 3] annulation involving oxidative activation of an unreactive C(sp3)–H bond: access to pyrimidine derivatives from amidines and ketones [J]. Org. Chem. Front., 2017, 4, 1107-1111.
18 Xiong W; Qi C; Guo T; Zhang M; Chen K; Jiang H. A copper-catalyzed oxidative coupling reaction of arylboronic acids, amines and carbon dioxide using molecular oxygen as the oxidant [J]. Green Chem., 2017, 19, 1642-1646.
19 Zhu C; Chen P; Zhu R; Lin Z; Wu W; Jiang H. C=N bond formation via palladium-catalyzed carbene insertion into N=N bonds: inhibiting the general 1,2-migration process of ylide intermediates [J]. Chem. Commun., 2017, 53, 2697-2700.
20 Peng Y; Liu J; Qi C; Yuan G; Li J; Jiang H. nBu4NI-catalyzed oxidative cross-coupling of carbon dioxide, amines, and aryl ketones: access to O-β-oxoalkyl carbamates [J]. Chem. Commun., 2017, 53, 2665-2668.
21 Li J; Hu W; Li C; Yang S; Wu W; Jiang H. Palladium-catalyzed cascade reaction of haloalkynes with unactivated alkenes for assembly of functionalized oxetanes [J]. Org. Chem. Front., 2017, 4, 373-376.
22 Chen P; Zhu C; Zhu R; Lin Z; Wu W; Jiang H. Synthesis of 3-azabicyclo[3.1.0]hexane derivatives via palladium-catalyzed cyclopropanation ofmaleimides with N-tosylhydrazones: practical and facile access to CP-866,087 [J]. Org. Biomol. Chem., 2017, 15, 1228-1235.
23 Yu Y; Chen Y; Wu W; Jiang H. Facile synthesis of cyanofurans via Michaeladdition/ cyclization of ene-yne-ketones with trimethylsilyl cyanide [J]. Chem. Commun., 2017, 53, 640-643.
24 Qi C; Peng Y; Ouyang, L; Ren Y; Jiang H. Base-promoted addition of arylacetonitriles to terminal alkynes: regio-and stereoselective access to disubstituted acrylonitriles [J]. Adv.Synth. Catal.,2017, 359,1339-1350.
25 Jiang G; Zhu C; Li J; Wu W; Jiang H. Silver-catalyzed regio- and stereoselective thiocyanation of haloalkynes: access to (z)-vinyl thiocyanates [J]. Adv. Synth. Catal.,2017, 359, 1208-1212.
26 Gao Y; Gao Y; Wu W; Jiang H; Yang X; Liu W; Li C.-J. Palladium-catalyzed tandem oxidative arylation/olefination of aromatic tethered alkenes/alkynes [J]. Chem. Eur.J.,2017 , 23,793-797.
2016
27 Yu Y; Huang W; Chen Y; Gao B; Wu W; Jiang H. Calcium carbide as the acetylide source: transition-metal-free synthesis of substituted pyrazoles via [1,5]-sigmatropic rearrangements [J]. Green Chem., 2016, 18, 6445-6449.
28 Wu Li; Zhang Z; Liao J; Li J; Wu W; Jiang H. MnO2-promoted carboesterification of alkenes with anhydrides: a facile approach to γ-lactones [J]. Chem. Commun., 2016, 52, 2628-2631.
29 Ren Y; Jiang O; Zeng H; Mao Q; Jiang H. Lewis acid-base bifunctional aluminum-salen catalysts: synthesis of cyclic carbonates from carbon dioxide and epoxides [J]. RSC Adv., 2016, 6, 3243-3249.
30 Zheng, M; Chen P; Wu W; Jiang H. Palladium-catalyzed Heck-type reaction of oximes with allylic alcohols: synthesis of pyridines and azafluorenones [J]. Chem. Commun., 2016, 52, 84-87.
31 Liang R; Chen K; Zhang Q; Zhang, J; Jiang, H; Zhu S. Rapid access to 2-methylene tetrahydrofurans and g-Lactones:a tandem four-step process [J]. Angew.Chem. Int.Ed.,2016, 55,2587-2591.
32 Xiao X; Hou C; Zhang Z; Ke Z; Lan J; Jiang H; Zeng W. Iridium(III)-catalyzed regioselective intermolecular unactivated secondary Csp3-H bond amidation [J]. Angew. Chem. Int. Ed.,2016, 55, 11897-11901.
33 Zheng J; Li Z; Wu W; Jiang H. Controllable O-nucleometalation cyclization strategy: access to divergent ring-functionalized molecules [J]. Org. Lett.,2016, 18, 6232-6235.
34 Hu W; Zheng J; Li J; Liu B; Wu W; Liu H; Jiang H. Assembly of polysubstituted maleimides via palladium-catalyzed cyclization reaction of alkynes with isocyanides [J]. J. Org. Chem.,2016, 81, 12451-12458.
35 Peng J; Gao Y; Hu, W; Gao Y; Hu M; Wu W; Ren Y; Jiang H. Palladium-catalyzed multicomponent reaction (MCR) of propargylic carbonates with isocyanides [J]. Org. Lett.,2016, 18, 5924-5927.
36 Li C; Li J; An Y; Peng J; Wu W; Jiang H. Palladium-catalyzed allylic C-H oxidative annulation for assembly of functionalized 2-substituted quinoline derivatives [J]. J. Org. Chem.,2016, 81, 12189-12196.
37 Tang X; Yang J; Zhu Z; Zheng M; Wu W; Jiang H. Access to thiazole via copper-catalyzed [3+1+1]-type condensation reaction under redox-neutral conditions [J]. J. Org. Chem.,2016, 81, 11461-11466.
38 Zhu C; Chen, P; Wu W; Qi C; Ren Y; Jiang H. Transition-metal-free diastereoselective epoxidation of tifluoromethylketones with N-tosylhydrazones: access to tetrasubstituted trifluoromethylated oxiranes [J]. Org. Lett.,2016, 18, 4008-4011.
39 Li J; Li C; Yang S; An Y; Wu W; Jiang H. Palladium-catalyzed oxidative sulfenylation of indoles and related electron-rich heteroarenes with aryl boronic acids and elemental sulfur [J]. J. Org. Chem.,2016, 81, 7771-7783.
40 Zheng J; Li Z; Huang L; Wu W; Li J; Jiang H. Palladium-catalyzed intermolecular aerobic annulation of o-alkenylanilines and alkynes for quinoline synthesis [J]. Org. Lett.,2016, 18, 3514-3517.
41 Guo W; Li C; Liao J; Ji F; Liu D; Wu W; Jiang H. Transition metal free intermolecular direct oxidative C-N bond formation to polysubstituted pyrimidines using molecular oxygen as the sole oxidant [J]. J. Org. Chem.,2016, 81, 5538-5546.
42 HuangY; Li X; Yu Y; Zhu C; Wu W; Jiang H. Copper-mediated [3 + 2] oxidative cyclization reaction of N-tosylhydrazones and β‑ketoesters: synthesis of 2,3,5-trisubstituted furans [J]. J. Org. Chem.,2016, 81, 5014-5020.
43 Li J; Li C; Yang S; An Y; Wu W; Jiang H. Assembly of 3‑sulfenylbenzofurans and 3-sulfenylindoles by palladium-catalyzed cascade annulation/arylthiolation reaction [J]. J. Org. Chem.,2016, 81, 2875-2887.
44 Zhu C; Li J; Chen P; Wu W; Ren Y; Jiang H. Transition-metal-free cyclopropanation of 2‑aminoacrylates with N-tosylhydrazones: a general route to cyclopropane α‑amino acid with contiguous quaternary carbon centers [J]. Org. Lett.,2016, 18, 1470-1473.
45 Gao Y; Gao Y; Tang X; Peng J; Hu M; Wu W; Jiang H. Copper-catalyzed oxysulfenylation of enolates with sodium sulfinates: a strategy to construct sulfenylated cyclic ethers [J]. Org. Lett.,2016, 18, 1158-1161.
46 Jiang H; Yang J; Tang X; Wu W. Divergent syntheses of isoquinolines and indolo[1,2-a]quinazolines by copper-catalyzed cascade annulation from 2-haloaryloxime acetates with active methylene compounds and indoles [J]. J. Org. Chem.,2016, 81, 2053-2061.
47 Zhu Z; Tang X; Li, Wu W; Deng G; Jiang H. Palladium-catalyzed C-H functionalization of aromatic oximes: a strategy for the synthesis of isoquinolines [J]. J. Org. Chem.,2016, 81, 1401-1409.
48 Yu Y; Yi S; Zhu C; Hu W; Gao B; Chen Y; Wu W; Jiang H. Csp3-P versus Csp2-P bond formation: catalyst-controlled highly regioselective tandem reaction of ene-yne-ketones with H-phosphonates [J]. Org. Lett.,2016, 18, 400-403.
49 Liao J; Guo W; Zhang Z; Tang X; Wu W; Jiang H. Metal-free catalyzed regioselective allylic trifluoromethanesulfonylation of aromatic allylic alcohols with sodium trifluoromethanesulfinate [J]. J. Org. Chem.,2016, 81, 1304-1309.
50 Ouyang L; Qi C; He H; Peng Y; Xiong W; Ren Y; Jiang H. Base-promoted formal [4 + 3] annulation between 2-fluorophenylacetylenes and ketones: a route to benzoxepines [J]. J. Org. Chem.,2016, 81, 912-919.
51 Tang X; Zhu Z; Qi C; Wu W; Jiang H. Copper-catalyzed coupling of oxime acetates with isothiocyanates: a strategy for 2-aminothiazoles [J]. Org. Lett.,2016, 18, 180-183.
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