1. Taian Lin, Yixuan Hou, Xueqing Liu, Ihsan Ullah, Siyu Qiu, Zidong Lu*, Jianyong Qi*, and Youyong Yuan*, Fluorinated Proteolysis Targeting Chimeras-Sorafenib Nanoassembly for Epigenetic Remodeling to Combat Multi-Pathway Drug Resistance in Hepatocellular Carcinoma, ACS Nano, 2025, 19, 34659-34676.

2. Haiyang Wang, Yixuan Hou, Taian Lin, Ihsan Ullah, Qing Xu, Ye Liu, Taosha Jin, Yangning Zhang and Youyong Yuan*, Sono-Responsive Hydrogel for Fractionated PROTAC Release to Alleviate Resistance and Immunosuppression Induced by Multi-Course Postoperative Radiotherapy, Adv. Funct. Mater., 2025, e12954.

3. Xiangyu Hu, Xiaofan Tan, Ihsan Ullah, Taosha Jin, Zhiqi Xu, Junyue Zhang, Zhenhai Pan, Youyong Yuan*, Jun Wang*, Velcro-inspired Poly(ethylene glycol)-Gel (PEGgel) for Robust Interface Adhesion Between Hydrogel, Device, and Tissue, ACS Nano, 2025, 19, 20128-20143.

4. Qing Xu, Xiangyu Hu, Ihsan Ullah, Taian Lin, Ye Liu, He Dong, Qingyu Zong, Youyong Yuan* and Jun Wang, Biomimetic Hybrid PROTAC Nanovesicles Block Multiple DNA Repair Pathways to Overcome Temozolomide Resistance against Orthotopic Glioblastoma, Adv. Mater., 2025, 2504253.

5. Xiaofan Tan, Xiangyu Hu, Xiaoyu Pan, Wenjiao Xie, Diyi Li, Youyong Yuan*, Jun Wang*, An Integrated Janus Patch with Asymmetric Tissue Adhesion for Enhanced Postoperative Adhesion Prevention. Polym. Sci. & Techn., 2025, 1, 120–131.

6. Ruili Wei, Kunfeng Xie, Tao Li, Wanxian Lin, Yandong Zhao, Jiamin Li, Shengsheng Lai, Xinhua Wei, Xinqing Jiang, Youyong Yuan*, Ruimeng Yang*, Immunity/metabolism dual-regulation via an acidity-triggered bioorthogonal assembly nanoplatform enhances glioblastoma immunotherapy by targeting CXCL12/CXCR4 and adenosine-A2AR pathways, Biomaterials, 2025, 319, 123216.

7. Ye Liu, Qingyu Zong, Yalan Tu*, Xingzu Zhang, Qiaoling Tan, Ihsan Ullah, Youyong Yuan*, A Tumor Heterogeneity-Independent Antigen-Responsive Nanocarrier Enabled by Bioorthogonal Pre-Targeting and Click-Activated Self-Immolative Polymer, Biomaterials, 2025, 319, 123200.

8. Maolin Jiang, Ye Liu, Kewei Wang, Yansong Dong, Xiangyu Hu and Youyong Yuan*, Mutual Reinforced Activatable NIR Fluorescence/MR Bimodal Imaging Enabled by Tumor-Specific Biomarker Amplification in Positive Feedback Loop, Cell Biomaterials, 2025, 1, 10044.

9. Taosha Jin, Haiyang Wang, Ihsan Ullah, Wenjiao Xie, Taian Lin, Qiaoling Tan, Xiaoyu Pan and Youyong Yuan*, A Wireless Operated Flexible Bioelectronic Microneedle Patch for Actively Controlled Transdermal Drug Delivery, Adv. Mater., 2025, 2417136.

10. Tao Li, Qingyu Zong, He Dong, Ihsan Ullah, Zhenhai Pan, Youyong Yuan*, Non-invasive monitoring of PROTACs mediated protein degradation in vivo using an environment-sensitive reporter, Nat. Commun., 2025, 16, 1892.

11. Mengchao Ding, Qingyu Zong, Dan Zhang, Ihsan Ullah, Xingzu Zhang, Wenhua Liang, Xinchun Li, Emil Bulatov, Youyong Yuan*, Self-Adaptive Nanocarriers Overcome Multiple Physiological Barriers to Boosting Chemotherapy of Orthotopic Pancreatic Cancer, ACS Nano, 2025, 19, 662–679.

12. 杨文军，谭巧玲，谢文姣，潘晓玉，袁友永*，海藻酸钙微米凝胶载药颗粒的构建及表征——高分子实验的新设计与教学实践，大学化学，2025，2405150。

13. Qingyu Zong, Jun Li, Qing Xu, Ye Liu, Kewei Wang and Youyong Yuan*, Self-immolative Poly(thiocarbamate) with Localized H₂S Signal Amplification for Precise Cancer Imaging and Therapy, Nat. Commun., 2024, 15, 7558.

14. Ye Liu, Haiyang Wang, Mengchao Ding, Wang Yao, Kewei Wang, Ihsan Ullah, Emil Bulatov, Youyong Yuan*, Ultrasound-Activated PROTAC Prodrugs Overcome Immunosuppression to Actuate Efficient Deep-Tissue Sono-Immunotherapy in Orthotopic Pancreatic Tumor Mouse Models, Nano Lett., 2024, 24, 8741–8751.

15. Xiajian Liu, Ihsan Ullah, Youyong Yuan*, Tumor Acidity-Triggered Bioorthogonal Reactions for Biomedical Applications, ChemBioChem, 2024, e202400452.

16. Xingzu Zhang, Qingyu Zong, Taian Lin, Ihsan Ullah, Maolin Jiang, Siyi Chen, Wenjie Tang, Yuan Guo, Youyong Yuan*, and Jinzhi Du*, Self-Assembled Metal-Phenolic Network Nanoparticles Delivery of Cisplatin Prodrug for Synergistic Chemo-Immunotherapy. Biomater. Sci., 2024, 12, 3649-3658.

17. Kewei Wang, Maolin Jiang, Tao Li, Ye Liu, Qingyu Zong, Qing Xu, Ihsan Ullah, Yahui Chen, Wei Xue, Youyong Yuan*, A Synergistic Chemoimmunotherapy System Leveraging PD-L1 Blocking and Bioorthogonal Prodrug Activation, Adv. Mater., 2024, 2402322.

18. Xiajian Liu, Nianhua Wang, Yixuan Hou, He Dong, Wenhua Liang, Xinchun Li*, Youyong Yuan*, A Highly Sensitive Ratiometric Fluorescent Immunoassay Based on Bioorthogonal Nanozymes. Chem. Commun., 2024, 60, 3978-3981.

19. Yansong Dong, Ye Liu, Yalan Tu, Youyong Yuan*, Jun Wang*, AIEgens Cross-Linked Iron Oxide Nanoparticles Synchronously Amplify Bimodal Imaging Signals in Situ by Tumor Acidity-Mediated Click Reaction. Angew. Chem. Int. Ed. 2023, 62, e202310975.

20. Yansong Dong, Yalan Tu, Ye Liu, Maolin Jiang, Emil Bulatov, Youyong Yuan*, Jun Wang*, Perivascular Nanocarrier Aggregation as A Drug Reservoir Augments Tumor Drug Delivery and Treatment Efficacy. Nano Today, 2023, 53, 102004.

21. Zhongyi Zhao, Qingyu Zong, Jun Li, Maolin Jiang, Kewei Wang, and Youyong Yuan*, Dual Stimulus-Triggered Biorthogonal Nanosystem for Spatiotemporally Controlled Prodrug Activation and Near-Infrared Fluorescence Imaging, Chem. Commun., 2023, 59, 3878-3881.

22. Jun Li, Qingyu Zong, Zhongyi Zhao, Youyong Yuan*, A Dual-Amplified ROS-Responsive Nanosystem with Self-Accelerating Drug Release for Synergistic Chemotherapy, Chem. Commun., 2023, 59, 3142-3145.

23. Ye Liu, Maolin Jiang, Zhongyi Zhao, Nianhua Wang, Kewei Wang, and Youyong Yuan*, Cyclic Amplification of Intracellular ROS Boosts Enzymatic Prodrug Activation for Enhanced Chemo-Immunotherapy, Acta Biomaterialia, 2023, 166, 567-580.

24. Xue Hu, Jie Li, Yuhao Zhang, Menghua Xiong*, Houbing Zhang*, Youyong Yuan*, A Helical Oncolytic Polypeptide with Potent Membranolytic Activity for Cancer Therapy, Biomater. Sci., 2023, 11, 1451-1458.

25. Maolin Jiang, Ye Liu, Yansong Dong, Kewei Wang, and Youyong Yuan*, Bioorthogonal Chemistry and Illumination Controlled Programmed Size-Changeable Nanomedicine for Synergistic Photodynamic and Hypoxia-Activated Therapy, Biomaterials, 2022, 284, 121480.

26. Yangyang Zhao, Yansong Dong, Shuhan Yang, Yalan Tu, Chengbo Wang, Jun Li, Youyong Yuan*, Zhexiong Lian. Bioorthognal Equipping CAR-T Cells with Hyaluronidase and Checkpoint Blocking Antibody for Enhanced Solid Tumor Immunotherapy, ACS Central Science, 2022, 8, 603–614.

27. Xuan Xiao, Qingyu Zong, Jisi Li, Youyong Yuan*, Tumor-Selective Cascade Amplified Dual-Prodrugs Activation for Synergistic Oxidation-Chemotherapy, CCS Chemistry,2022, 4, 3878-3888.

28. Jielian Zhou, Kewei Wang, Maolin Jiang, Jisi Li, Youyong Yuan*, Tumor-Acidity and Bioorthogonal Chemistry-Mediated Construction and Deconstruction of Drug Depots for Ferroptosis under Normoxia and Hypoxia, Acta Biomaterialia, 2022, 142, 253-263.

29. Kewei Wang, Maolin Jiang, Jielian Zhou, Ye Liu, Qingyu Zong, and Youyong Yuan*, Tumor-Acidity and Bioorthogonal Chemistry-Mediated On-Site Size Transformation Clustered Nanosystem to Overcome Hypoxic Resistance and Enhance Chemoimmunotherapy, ACS Nano, 2022, 16, 721-735.

30. Jisi Li, Qingyu Zong, Ye Liu, Xuan Xiao, Jielian Zhou, Zhongyi Zhao, Youyong Yuan*, Self-catalyzed Tumor Ferroptosis Based on Ferrocene Conjugated Reactive Oxygen Species Generate and Responsive Polymer, Chemical Communications, 2022, 58, 3294-3297.

31. Yuchen Du, Yuan Guo, Xuan Xiao, Xiaonan Zhu, Ye Liu, Xiuhang Ruan, Xiaofei Huang, Youyong Yuan*, Xinhua Wei*, Glutathione Depletion and Photosensitizer Activation Augments Efficacy of Tumor Photodynamic Immunotherapy, Chemical Engineering Journal, 2022, 442, 136170.

32. Qingyu Zong, Xuan Xiao, Jisi Li, Youyong Yuan*, Self-boosting Stimulus Activation of A Polyprodrug with Cascade Amplification for Enhanced Antitumor Efficacy, Biomater. Sci., 2022,10, 4228-4234.

33. Kewei Wang, Maolin Jiang, Jielian Zhou, Yansong Dong, Ye Liu, Qingyu Zong, Puja Sandbhor, N. D. Pradeep Singh, Youyong Yuan*, Spatial Specific Delivery of Combinational Chemotherapeutics to Combat Intratumoral Heterogeneity, Journal of Controlled Release, 2022, 348, 1004-1015.

34. Yalan Tu, Xuan Xiao, Yansong Dong, Jisi Li, Ye Liu, Qingyu Zong, Youyong Yuan*, Cinnamaldehyde-based Poly(thioacetal): A Ros-Awakened Self-Amplifying Degradable Polymer for Enhanced Cancer Immunotherapy, Biomaterials, 2022, 289, 121795.

35. Kewei Wang, Xuan Xiao, Ye Liu, Qingyu Zong, Yalan Tu, Youyong Yuan*, Self-Immolative Polyprodrug-Based Tumor-Specific Cascade Amplificated Drug Release Nanosystem for Orchestrated Synergistic Cancer Therapy, Biomaterials, 2022, 289, 121803.

36. Qingyu Zong, Jisi Li, Xuan Xiao, Xiaojiao Du*, Youyong Yuan*, Self-Amplified Chain-Shattering Cinnamaldehyde-Based Poly(thioacetal) Boosts Cancer Chemo-Immunotherapy, Acta Biomaterialia, 2022, 154, 97-107

37. Ye Liu, Maolin Jiang, Yalan Tu, Kewei Wang, Qingyu Zong, Youyong Yuan*, Time-Programmed Actiavation of Dual Polyprodrugs for Synergistic Cascade Oxidation-Chemotherapy, Biomaterials, 2021, 278, 121136.

38. Maolin Jiang, Kewei Wang, Xuan Xiao, Qingyu Zong, Rui Zheng, Youyong Yuan*, Theranostic Heterodimeric Prodrug with Dual-Channel Fluorescence Turn-On and Dual-Prodrug Activation for Synergistic Cancer Therapy, Advanced Healthcare Materials, 2021, 10, 2101144.

39. Di Ma, Qingyu Zong, Yuchen Du, Fangzhou Yu, Xuan Xiao, Rong Sun, Yuan Guo*, Xinhua Wei*, Youyong Yuan*, Sequential Enzyme-Activated Macrotheranostic Probe for Selective Tumor Mitochondria Targeting, Acta Biomaterialia, 2021, 135, 628-637.

40. Qingyu Zong, Kewei Wang, Xuan Xiao, Maolin Jiang, Jisi Li, Youyong Yuan*, Jun Wang*, Amplification of Tumor Oxidative Stresses by Poly(Disulfide Acetal) for Multidrug Resistance Reversal, Biomaterials, 2021, 276, 121005.

41. Qingyu Zong, Rui Zheng, Xuan Xiao, Maolin Jiang, Jisi Li, Youyong Yuan*, Dual-locking Nanoprobe Based on Hemicyanine for Orthogonal Stimuli-Triggered Precise Cancer Imaging And Therapy, J. Control. Release, 2021, 338, 307-315.

42. Kewei Wang, Xuan Xiao, Maolin Jiang, Jisi Li, Jielian Zhou, Youyong Yuan*, An NIR-Fluorophore-Based Theranostic for Selective Initiation of Tumor Pyroptosis-Induced Immunotherapy, Small, 2021, 17, 2102610.

43. Ruili Wei, Yansong Dong, Yalan Tu, Shiwei Luo, Xinrui Pang, Wanli Zhang, Wang Yao, Wenjie Tang, 5 Huikang Yang, Xinhua Wei, Xinqing Jiang*, Youyong Yuan*, and Ruimeng Yang.* Bioorthogonal Pretargeting Strategy for Anchoring Activatable Photosensitizers on Plasma Membranes for Effective Photodynamic Therapy. ACS Appl. Mater. Interfaces, 2021, 13, 14004-14014.

44. Fangzhou Yu, Yalan Tu, Shiwei Luo, Xuan Xiao, Wang Yao, Maolin Jiang, Xinqing Jiang*, Ruimeng Yang*, Youyong Yuan*, Dual-Drug Backboned Polyprodrug with a Predefined Drug Combination for Synergistic Chemotherapy, Nano Letters, 2021, 21, 2216-2223.

45. Yalan Tu, Rui Zheng, Fangzhou Yu, Xuan Xiao, Maoling Jiang, Youyong Yuan*, Dual Drug Delivery System with Flexible And Controllable Drug Ratios For Synergistic Chemotherapy. Sci. China Chem. (中国科学:化学) 2021, 64, 1020-1030.

46. Xuan Xiao, Kewei Wang, Qingyu Zong, Yalan Tu, Yansong Dong, Youyong Yuan*, Polyprodrug with Glutathione Depletion and Cascade Drug Activation for Multi-drug Resistance Reversal, Biomaterials, 2021, 270, 120649.

47. Yalan Tu, Yansong Dong, Kewei Wang, Song Shen, Youyong Yuan*, Jun Wang*, Intercellular Delivery of Bioorthogonal Chemical Receptors for Enhanced Tumor Targeting and Penetration, Biomaterials, 2020, 259, 120298.

48. Yansong Dong, Yalan Tu, Kewei Wang, Congfei Xu, Youyong Yuan*, Jun Wang*, A General Strategy for Macrotheranostic Prodrug Activation: Synergy by Tumor Acidic Microenvironment and Bioorthogonal Chemistry. Angew. Chem. Int. Ed., 2020, 59, 7168-7172.

49. Kewei Wang, Yalan Tu, Wang Yao, Qingyu Zong, Xuan Xiao, Rui-Meng Yang*, Xin-Qing Jiang*, Youyong Yuan*, Size-Switchable Nanoparticles with Self-Destructive and Tumor Penetration Characteristics for Site-Specific Phototherapy of Cancer. ACS Appl. Mater. Interfaces, 2020, 12, 6933-6943.

50. Yansong Dong, Bin Liu*, Youyong Yuan*, AIEgen Based Drug Delivery Systems For Cancer Therapy. J. Control. Release, 2018, 290, 129-137.

51. Youyong Yuan, Shidang Xu, Xiamin Cheng, Xiaolei Cai, and Bin Liu*, Bioorthogonal Turn-On Probe based on AIEgen for Cancer Cell Imaging and Ablation. Angew. Chem. Int. Ed., 2016, 55, 6457-6461.

52. Youyong Yuan, Chong-Jing Zhang, and Bin Liu*, Photoactivatable AIE Polymer for Light Controlled Gene Delivery: Concurrent Endo-/Lysosomal Escaping and DNA Unpacking. Angew. Chem. Int. Ed., 2015, 54, 11419-11423.

53. Youyong Yuan, Chong-Jing Zhang, Meng Gao, Ruoyu Zhang, Ben Zhong Tang, Bin Liu*, Specific Light-up Bioprobe with Aggregation-Induced Emission and Activatable Photoactivity for Targeted and Image-Guided Photodynamic Ablation of Cancer Cells. Angew. Chem. Int. Ed., 2015, 54, 1780-1786.

54. Youyong Yuan, Ryan T. K. Kwok, Ben Zhong Tang,* Bin Liu*, Targeted Theranostic Platinum (IV) Prodrug with a Built-in Aggregation-Induced Emission Light-up Apoptosis Sensor for Noninvasive Early Evaluation of its Therapeutic Responses In-situ. J. Am. Chem. Soc., 2014, 136, 2546-2554.

55. Youyong Yuan, Jie Liu, Bin Liu*, Conjugated Polyelectrolyte based Polyprodrug: Targeted and Imaging Guided Photodynamic and Chemotherapy with On-demand Drug Release upon Single Light Irradiation. Angew. Chem. Int. Ed., 2014, 53, 7163-7168.

56. Youyong Yuan, Chengqiong Mao, Xiaojiao Du, Jinzhi Du, Feng Wang, Jun Wang*, Surface Charge Switchable Nanoparticles based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor. Adv. Mater., 2012, 24, 5476-5480.

57. Youyong Yuan, Chong-Jing Zhang, Ryan T. K. Kwok, Shidang Xu, Ruoyu Zhang, Jien Wu, Ben Zhong Tang*, and Bin Liu*, Light-Up Probe for Targeted and Activatable Photodynamic Therapy with Real-Time In Situ Reporting of Sensitizer Activation and Therapeutic Responses. Adv. Funct. Mater., 2015, 25, 6586-6595.

58. Youyong Yuan, Ruoyu Zhang, Xiamin Cheng, Shidang Xu, and Bin Liu*, FRET Probe with AIEgen as the Energy Quencher: Dual Signal Turn-On for Self-Validated Caspase Detection. Chem. Sci., 2016, 7, 4245-4250.

59. Youyong Yuan, Chong-Jing Zhang, Shidang Xu and Bin Liu*, A Self-Reporting Aie Probe With A Built-In Singlet Oxygen Sensor For Targeted Photodynamic Ablation Of Cancer Cells. Chem. Sci., 2016, 7, 1862-1866.

60. Shidang Xu, Youyong Yuan, Xiaolei Cai, Chong-Jing Zhang, Fang Hu, Jing Liang, Guanxin Zhang, Deqing Zhang, Bin Liu*, Tuning the Singlet-Triplet Energy Gap: Unique Approach to Efficient Photosensitizers with Aggregation-Induced Emission (AIE) Characteristics. Chem. Sci., 2015, 6, 5824-5830.

61. Youyong Yuan, Ryan T. K. Kwok, Ben Zhong Tang*, and Bin Liu*, Smart Probe for Tracing Cancer Therapy: Selective Cancer Cell Detection, Image-Guided Ablation, and Prediction of Therapeutic Response in Situ. Small, 2015, 11, 4682–4690.

62. Youyong Yuan, Dan Ding, Kai Li, Jie Liu, Bin Liu*, Tumor-responsive Fluorescent Light-up Probe based on a Gold Nanoparticle/Conjugated Polyelectrolyte Hybrid. Small, 2014, 10, 1967-1975.

63. Youyong Yuan, Jin-Zhi Du, Wen-Jing Song, Feng Wang, Xian-Zhu Yang, Meng-Hua Xiong, Jun Wang*, Biocompatible and Functionalizable Polyphosphate Nanogels with A Branched Structure. J. Mater Chem., 2012, 22, 9322-9329.

64. Youyong Yuan, Shidang Xu, Chong-Jing Zhang, Ruoyu Zhang, Bin Liu*, Dual-targeted Activatable Photosensitizer with Aggregation-Induced Emission (AIE) Characteristics for Image-Guided Photodynamic Cancer Therapy. J. Mater. Chem. B, 2016, 4, 169-176.

65. Youyong Yuan, Zuyong Wang, Pinqiang Cai, Jie Liu, Lunde Liao, Minghui Hong, Xiaodong Chen, Nitish Thakord and Bin Liu*, Conjugated Polymer and Drug Co-encapsulated Nanoparticles for Chemo-and Photo-thermal Combination Therapy with Two-Photon Regulated Fast Drug Release. Nanoscale, 2015, 7, 3067-3076.

66. Youyong Yuan, Yuanzeng Min, Qinglian Hu, Bengang Xing, Bin Liu*, NIR Photoregulated On-demand Chemo-Photodynamic Cancer Therapy based on Upconversion Nanoparticles/Conjugated Polyelectrolyte Hybrid. Nanoscale, 2014, 6, 11259-11272.

67. Youyong Yuan, and Bin Liu*, Self-Assembled Nanoparticles Based on PEGylated Conjugated Polyelectrolyte and Drug Molecules for Image-Guided Drug Delivery and Photodynamic Therapy. ACS Appl. Mater. Interfaces, 2014, 6, 14903-14910.

68. Youyong Yuan, Chong-Jing Zhang, Bin Liu*, A Platinum Prodrug Conjugated with a Photosensitizer with Aggregation-Induced Emission (AIE) Characteristics for Drug Activation Monitoring and Combinatorial Photodynamic–Chemotherapy against Cisplatin Resistant Cancer Cells. Chem. Commun., 2015, 51, 8626-8629.

69. Youyong Yuan, Guangxue Feng, Wei Qin, Ben Zhong Tang, Bin Liu*, Targeted and Image-Guided Photodynamic Cancer Therapy based on Organic Nanoparticles with Aggregation-Induced Emission Characteristics. Chem. Commun., 2014, 50, 8757-8760.

70. Youyong Yuan, Ryan T. K. Kwok, Guangxue Feng, Jing Liang, Junlong Geng, Ben Zhong Tang*, Bin Liu*, Rational Design of Fluorescent Light-up Probes based on an AIE Luminogen for Targeted Intracellular Thiol Imaging. Chem. Commun., 2014, 50, 295-297.

71. Youyong Yuan, Yilong Chen, Ben Zhong Tang*, Bin Liu*, A Targeted Theranostic Platinum (IV) Prodrug Containing a Luminogen with Aggregation-Induced Emission (AIE) Characteristics for In Situ Monitoring of Drug Activation. Chem. Commun., 2014, 50, 3868-3870.

72. Youyong Yuan, Ryan T. K. Kwok, Ruoyu Zhang, Ben Zhong Tang*, Bin Liu*, Targeted Theranostic Prodrug Based on an Aggregation-Induced Emission (AIE) Luminogen for Real-Time Dual-Drug Tracking. Chem. Commun., 2014, 50, 11465-11468.

73. Youyong Yuan, Jinzhi Du, and Jun Wang*, Two Consecutive Click Reactions as a General Route to Functional Cyclic Polyesters, Chem. Commun., 2012, 48, 570-572.

74. Youyong Yuan, Shidang Xu, Chong-Jing Zhang, Bin Liu*, Light-Responsive AIE Nanoparticles With Cytosolic Drug Release To Overcome Drug Resistance In Cancer Cells, Polym. Chem., 2016, 7, 3530-3539.

1. Taian Lin, Yixuan Hou, Xueqing Liu, Ihsan Ullah, Siyu Qiu, Zidong Lu*, Jianyong Qi*, and Youyong Yuan*, Fluorinated Proteolysis Targeting Chimeras-Sorafenib Nanoassembly for Epigenetic Remodeling to Combat Multi-Pathway Drug Resistance in Hepatocellular Carcinoma, ACS Nano, 2025, 19, 34659-34676.

2. Haiyang Wang, Yixuan Hou, Taian Lin, Ihsan Ullah, Qing Xu, Ye Liu, Taosha Jin, Yangning Zhang and Youyong Yuan*, Sono-Responsive Hydrogel for Fractionated PROTAC Release to Alleviate Resistance and Immunosuppression Induced by Multi-Course Postoperative Radiotherapy, Adv. Funct. Mater., 2025, e12954.

3. Xiangyu Hu, Xiaofan Tan, Ihsan Ullah, Taosha Jin, Zhiqi Xu, Junyue Zhang, Zhenhai Pan, Youyong Yuan*, Jun Wang*, Velcro-inspired Poly(ethylene glycol)-Gel (PEGgel) for Robust Interface Adhesion Between Hydrogel, Device, and Tissue, ACS Nano, 2025, 19, 20128-20143.

4. Qing Xu, Xiangyu Hu, Ihsan Ullah, Taian Lin, Ye Liu, He Dong, Qingyu Zong, Youyong Yuan* and Jun Wang, Biomimetic Hybrid PROTAC Nanovesicles Block Multiple DNA Repair Pathways to Overcome Temozolomide Resistance against Orthotopic Glioblastoma, Adv. Mater., 2025, 2504253.

5. Xiaofan Tan, Xiangyu Hu, Xiaoyu Pan, Wenjiao Xie, Diyi Li, Youyong Yuan*, Jun Wang*, An Integrated Janus Patch with Asymmetric Tissue Adhesion for Enhanced Postoperative Adhesion Prevention. Polym. Sci. & Techn., 2025, 1, 120–131.

6. Ruili Wei, Kunfeng Xie, Tao Li, Wanxian Lin, Yandong Zhao, Jiamin Li, Shengsheng Lai, Xinhua Wei, Xinqing Jiang, Youyong Yuan*, Ruimeng Yang*, Immunity/metabolism dual-regulation via an acidity-triggered bioorthogonal assembly nanoplatform enhances glioblastoma immunotherapy by targeting CXCL12/CXCR4 and adenosine-A2AR pathways, Biomaterials, 2025, 319, 123216.

7. Ye Liu, Qingyu Zong, Yalan Tu*, Xingzu Zhang, Qiaoling Tan, Ihsan Ullah, Youyong Yuan*, A Tumor Heterogeneity-Independent Antigen-Responsive Nanocarrier Enabled by Bioorthogonal Pre-Targeting and Click-Activated Self-Immolative Polymer, Biomaterials, 2025, 319, 123200.

8. Maolin Jiang, Ye Liu, Kewei Wang, Yansong Dong, Xiangyu Hu and Youyong Yuan*, Mutual Reinforced Activatable NIR Fluorescence/MR Bimodal Imaging Enabled by Tumor-Specific Biomarker Amplification in Positive Feedback Loop, Cell Biomaterials, 2025, 1, 10044.

9. Taosha Jin, Haiyang Wang, Ihsan Ullah, Wenjiao Xie, Taian Lin, Qiaoling Tan, Xiaoyu Pan and Youyong Yuan*, A Wireless Operated Flexible Bioelectronic Microneedle Patch for Actively Controlled Transdermal Drug Delivery, Adv. Mater., 2025, 2417136.

10. Tao Li, Qingyu Zong, He Dong, Ihsan Ullah, Zhenhai Pan, Youyong Yuan*, Non-invasive monitoring of PROTACs mediated protein degradation in vivo using an environment-sensitive reporter, Nat. Commun., 2025, 16, 1892.

11. Mengchao Ding, Qingyu Zong, Dan Zhang, Ihsan Ullah, Xingzu Zhang, Wenhua Liang, Xinchun Li, Emil Bulatov, Youyong Yuan*, Self-Adaptive Nanocarriers Overcome Multiple Physiological Barriers to Boosting Chemotherapy of Orthotopic Pancreatic Cancer, ACS Nano, 2025, 19, 662–679.

12. 杨文军，谭巧玲，谢文姣，潘晓玉，袁友永*，海藻酸钙微米凝胶载药颗粒的构建及表征——高分子实验的新设计与教学实践，大学化学，2025，2405150。

13. Qingyu Zong, Jun Li, Qing Xu, Ye Liu, Kewei Wang and Youyong Yuan*, Self-immolative Poly(thiocarbamate) with Localized H₂S Signal Amplification for Precise Cancer Imaging and Therapy, Nat. Commun., 2024, 15, 7558.

14. Ye Liu, Haiyang Wang, Mengchao Ding, Wang Yao, Kewei Wang, Ihsan Ullah, Emil Bulatov, Youyong Yuan*, Ultrasound-Activated PROTAC Prodrugs Overcome Immunosuppression to Actuate Efficient Deep-Tissue Sono-Immunotherapy in Orthotopic Pancreatic Tumor Mouse Models, Nano Lett., 2024, 24, 8741–8751.

15. Xiajian Liu, Ihsan Ullah, Youyong Yuan*, Tumor Acidity-Triggered Bioorthogonal Reactions for Biomedical Applications, ChemBioChem, 2024, e202400452.

16. Xingzu Zhang, Qingyu Zong, Taian Lin, Ihsan Ullah, Maolin Jiang, Siyi Chen, Wenjie Tang, Yuan Guo, Youyong Yuan*, and Jinzhi Du*, Self-Assembled Metal-Phenolic Network Nanoparticles Delivery of Cisplatin Prodrug for Synergistic Chemo-Immunotherapy. Biomater. Sci., 2024, 12, 3649-3658.

17. Kewei Wang, Maolin Jiang, Tao Li, Ye Liu, Qingyu Zong, Qing Xu, Ihsan Ullah, Yahui Chen, Wei Xue, Youyong Yuan*, A Synergistic Chemoimmunotherapy System Leveraging PD-L1 Blocking and Bioorthogonal Prodrug Activation, Adv. Mater., 2024, 2402322.

18. Xiajian Liu, Nianhua Wang, Yixuan Hou, He Dong, Wenhua Liang, Xinchun Li*, Youyong Yuan*, A Highly Sensitive Ratiometric Fluorescent Immunoassay Based on Bioorthogonal Nanozymes. Chem. Commun., 2024, 60, 3978-3981.

19. Yansong Dong, Ye Liu, Yalan Tu, Youyong Yuan*, Jun Wang*, AIEgens Cross-Linked Iron Oxide Nanoparticles Synchronously Amplify Bimodal Imaging Signals in Situ by Tumor Acidity-Mediated Click Reaction. Angew. Chem. Int. Ed. 2023, 62, e202310975.

20. Yansong Dong, Yalan Tu, Ye Liu, Maolin Jiang, Emil Bulatov, Youyong Yuan*, Jun Wang*, Perivascular Nanocarrier Aggregation as A Drug Reservoir Augments Tumor Drug Delivery and Treatment Efficacy. Nano Today, 2023, 53, 102004.

21. Zhongyi Zhao, Qingyu Zong, Jun Li, Maolin Jiang, Kewei Wang, and Youyong Yuan*, Dual Stimulus-Triggered Biorthogonal Nanosystem for Spatiotemporally Controlled Prodrug Activation and Near-Infrared Fluorescence Imaging, Chem. Commun., 2023, 59, 3878-3881.

22. Jun Li, Qingyu Zong, Zhongyi Zhao, Youyong Yuan*, A Dual-Amplified ROS-Responsive Nanosystem with Self-Accelerating Drug Release for Synergistic Chemotherapy, Chem. Commun., 2023, 59, 3142-3145.

23. Ye Liu, Maolin Jiang, Zhongyi Zhao, Nianhua Wang, Kewei Wang, and Youyong Yuan*, Cyclic Amplification of Intracellular ROS Boosts Enzymatic Prodrug Activation for Enhanced Chemo-Immunotherapy, Acta Biomaterialia, 2023, 166, 567-580.

24. Xue Hu, Jie Li, Yuhao Zhang, Menghua Xiong*, Houbing Zhang*, Youyong Yuan*, A Helical Oncolytic Polypeptide with Potent Membranolytic Activity for Cancer Therapy, Biomater. Sci., 2023, 11, 1451-1458.

25. Maolin Jiang, Ye Liu, Yansong Dong, Kewei Wang, and Youyong Yuan*, Bioorthogonal Chemistry and Illumination Controlled Programmed Size-Changeable Nanomedicine for Synergistic Photodynamic and Hypoxia-Activated Therapy, Biomaterials, 2022, 284, 121480.

26. Yangyang Zhao, Yansong Dong, Shuhan Yang, Yalan Tu, Chengbo Wang, Jun Li, Youyong Yuan*, Zhexiong Lian. Bioorthognal Equipping CAR-T Cells with Hyaluronidase and Checkpoint Blocking Antibody for Enhanced Solid Tumor Immunotherapy, ACS Central Science, 2022, 8, 603–614.

27. Xuan Xiao, Qingyu Zong, Jisi Li, Youyong Yuan*, Tumor-Selective Cascade Amplified Dual-Prodrugs Activation for Synergistic Oxidation-Chemotherapy, CCS Chemistry,2022, 4, 3878-3888.

28. Jielian Zhou, Kewei Wang, Maolin Jiang, Jisi Li, Youyong Yuan*, Tumor-Acidity and Bioorthogonal Chemistry-Mediated Construction and Deconstruction of Drug Depots for Ferroptosis under Normoxia and Hypoxia, Acta Biomaterialia, 2022, 142, 253-263.

29. Kewei Wang, Maolin Jiang, Jielian Zhou, Ye Liu, Qingyu Zong, and Youyong Yuan*, Tumor-Acidity and Bioorthogonal Chemistry-Mediated On-Site Size Transformation Clustered Nanosystem to Overcome Hypoxic Resistance and Enhance Chemoimmunotherapy, ACS Nano, 2022, 16, 721-735.

30. Jisi Li, Qingyu Zong, Ye Liu, Xuan Xiao, Jielian Zhou, Zhongyi Zhao, Youyong Yuan*, Self-catalyzed Tumor Ferroptosis Based on Ferrocene Conjugated Reactive Oxygen Species Generate and Responsive Polymer, Chemical Communications, 2022, 58, 3294-3297.

31. Yuchen Du, Yuan Guo, Xuan Xiao, Xiaonan Zhu, Ye Liu, Xiuhang Ruan, Xiaofei Huang, Youyong Yuan*, Xinhua Wei*, Glutathione Depletion and Photosensitizer Activation Augments Efficacy of Tumor Photodynamic Immunotherapy, Chemical Engineering Journal, 2022, 442, 136170.

32. Qingyu Zong, Xuan Xiao, Jisi Li, Youyong Yuan*, Self-boosting Stimulus Activation of A Polyprodrug with Cascade Amplification for Enhanced Antitumor Efficacy, Biomater. Sci., 2022,10, 4228-4234.

33. Kewei Wang, Maolin Jiang, Jielian Zhou, Yansong Dong, Ye Liu, Qingyu Zong, Puja Sandbhor, N. D. Pradeep Singh, Youyong Yuan*, Spatial Specific Delivery of Combinational Chemotherapeutics to Combat Intratumoral Heterogeneity, Journal of Controlled Release, 2022, 348, 1004-1015.

34. Yalan Tu, Xuan Xiao, Yansong Dong, Jisi Li, Ye Liu, Qingyu Zong, Youyong Yuan*, Cinnamaldehyde-based Poly(thioacetal): A Ros-Awakened Self-Amplifying Degradable Polymer for Enhanced Cancer Immunotherapy, Biomaterials, 2022, 289, 121795.

35. Kewei Wang, Xuan Xiao, Ye Liu, Qingyu Zong, Yalan Tu, Youyong Yuan*, Self-Immolative Polyprodrug-Based Tumor-Specific Cascade Amplificated Drug Release Nanosystem for Orchestrated Synergistic Cancer Therapy, Biomaterials, 2022, 289, 121803.

36. Qingyu Zong, Jisi Li, Xuan Xiao, Xiaojiao Du*, Youyong Yuan*, Self-Amplified Chain-Shattering Cinnamaldehyde-Based Poly(thioacetal) Boosts Cancer Chemo-Immunotherapy, Acta Biomaterialia, 2022, 154, 97-107

37. Ye Liu, Maolin Jiang, Yalan Tu, Kewei Wang, Qingyu Zong, Youyong Yuan*, Time-Programmed Actiavation of Dual Polyprodrugs for Synergistic Cascade Oxidation-Chemotherapy, Biomaterials, 2021, 278, 121136.

38. Maolin Jiang, Kewei Wang, Xuan Xiao, Qingyu Zong, Rui Zheng, Youyong Yuan*, Theranostic Heterodimeric Prodrug with Dual-Channel Fluorescence Turn-On and Dual-Prodrug Activation for Synergistic Cancer Therapy, Advanced Healthcare Materials, 2021, 10, 2101144.

39. Di Ma, Qingyu Zong, Yuchen Du, Fangzhou Yu, Xuan Xiao, Rong Sun, Yuan Guo*, Xinhua Wei*, Youyong Yuan*, Sequential Enzyme-Activated Macrotheranostic Probe for Selective Tumor Mitochondria Targeting, Acta Biomaterialia, 2021, 135, 628-637.

40. Qingyu Zong, Kewei Wang, Xuan Xiao, Maolin Jiang, Jisi Li, Youyong Yuan*, Jun Wang*, Amplification of Tumor Oxidative Stresses by Poly(Disulfide Acetal) for Multidrug Resistance Reversal, Biomaterials, 2021, 276, 121005.

41. Qingyu Zong, Rui Zheng, Xuan Xiao, Maolin Jiang, Jisi Li, Youyong Yuan*, Dual-locking Nanoprobe Based on Hemicyanine for Orthogonal Stimuli-Triggered Precise Cancer Imaging And Therapy, J. Control. Release, 2021, 338, 307-315.

42. Kewei Wang, Xuan Xiao, Maolin Jiang, Jisi Li, Jielian Zhou, Youyong Yuan*, An NIR-Fluorophore-Based Theranostic for Selective Initiation of Tumor Pyroptosis-Induced Immunotherapy, Small, 2021, 17, 2102610.

43. Ruili Wei, Yansong Dong, Yalan Tu, Shiwei Luo, Xinrui Pang, Wanli Zhang, Wang Yao, Wenjie Tang, 5 Huikang Yang, Xinhua Wei, Xinqing Jiang*, Youyong Yuan*, and Ruimeng Yang.* Bioorthogonal Pretargeting Strategy for Anchoring Activatable Photosensitizers on Plasma Membranes for Effective Photodynamic Therapy. ACS Appl. Mater. Interfaces, 2021, 13, 14004-14014.

44. Fangzhou Yu, Yalan Tu, Shiwei Luo, Xuan Xiao, Wang Yao, Maolin Jiang, Xinqing Jiang*, Ruimeng Yang*, Youyong Yuan*, Dual-Drug Backboned Polyprodrug with a Predefined Drug Combination for Synergistic Chemotherapy, Nano Letters, 2021, 21, 2216-2223.

45. Yalan Tu, Rui Zheng, Fangzhou Yu, Xuan Xiao, Maoling Jiang, Youyong Yuan*, Dual Drug Delivery System with Flexible And Controllable Drug Ratios For Synergistic Chemotherapy. Sci. China Chem. (中国科学:化学) 2021, 64, 1020-1030.

46. Xuan Xiao, Kewei Wang, Qingyu Zong, Yalan Tu, Yansong Dong, Youyong Yuan*, Polyprodrug with Glutathione Depletion and Cascade Drug Activation for Multi-drug Resistance Reversal, Biomaterials, 2021, 270, 120649.

47. Yalan Tu, Yansong Dong, Kewei Wang, Song Shen, Youyong Yuan*, Jun Wang*, Intercellular Delivery of Bioorthogonal Chemical Receptors for Enhanced Tumor Targeting and Penetration, Biomaterials, 2020, 259, 120298.

48. Yansong Dong, Yalan Tu, Kewei Wang, Congfei Xu, Youyong Yuan*, Jun Wang*, A General Strategy for Macrotheranostic Prodrug Activation: Synergy by Tumor Acidic Microenvironment and Bioorthogonal Chemistry. Angew. Chem. Int. Ed., 2020, 59, 7168-7172.

49. Kewei Wang, Yalan Tu, Wang Yao, Qingyu Zong, Xuan Xiao, Rui-Meng Yang*, Xin-Qing Jiang*, Youyong Yuan*, Size-Switchable Nanoparticles with Self-Destructive and Tumor Penetration Characteristics for Site-Specific Phototherapy of Cancer. ACS Appl. Mater. Interfaces, 2020, 12, 6933-6943.

50. Yansong Dong, Bin Liu*, Youyong Yuan*, AIEgen Based Drug Delivery Systems For Cancer Therapy. J. Control. Release, 2018, 290, 129-137.

51. Youyong Yuan, Shidang Xu, Xiamin Cheng, Xiaolei Cai, and Bin Liu*, Bioorthogonal Turn-On Probe based on AIEgen for Cancer Cell Imaging and Ablation. Angew. Chem. Int. Ed., 2016, 55, 6457-6461.

52. Youyong Yuan, Chong-Jing Zhang, and Bin Liu*, Photoactivatable AIE Polymer for Light Controlled Gene Delivery: Concurrent Endo-/Lysosomal Escaping and DNA Unpacking. Angew. Chem. Int. Ed., 2015, 54, 11419-11423.

53. Youyong Yuan, Chong-Jing Zhang, Meng Gao, Ruoyu Zhang, Ben Zhong Tang, Bin Liu*, Specific Light-up Bioprobe with Aggregation-Induced Emission and Activatable Photoactivity for Targeted and Image-Guided Photodynamic Ablation of Cancer Cells. Angew. Chem. Int. Ed., 2015, 54, 1780-1786.

54. Youyong Yuan, Ryan T. K. Kwok, Ben Zhong Tang,* Bin Liu*, Targeted Theranostic Platinum (IV) Prodrug with a Built-in Aggregation-Induced Emission Light-up Apoptosis Sensor for Noninvasive Early Evaluation of its Therapeutic Responses In-situ. J. Am. Chem. Soc., 2014, 136, 2546-2554.

55. Youyong Yuan, Jie Liu, Bin Liu*, Conjugated Polyelectrolyte based Polyprodrug: Targeted and Imaging Guided Photodynamic and Chemotherapy with On-demand Drug Release upon Single Light Irradiation. Angew. Chem. Int. Ed., 2014, 53, 7163-7168.

56. Youyong Yuan, Chengqiong Mao, Xiaojiao Du, Jinzhi Du, Feng Wang, Jun Wang*, Surface Charge Switchable Nanoparticles based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor. Adv. Mater., 2012, 24, 5476-5480.

57. Youyong Yuan, Chong-Jing Zhang, Ryan T. K. Kwok, Shidang Xu, Ruoyu Zhang, Jien Wu, Ben Zhong Tang*, and Bin Liu*, Light-Up Probe for Targeted and Activatable Photodynamic Therapy with Real-Time In Situ Reporting of Sensitizer Activation and Therapeutic Responses. Adv. Funct. Mater., 2015, 25, 6586-6595.

58. Youyong Yuan, Ruoyu Zhang, Xiamin Cheng, Shidang Xu, and Bin Liu*, FRET Probe with AIEgen as the Energy Quencher: Dual Signal Turn-On for Self-Validated Caspase Detection. Chem. Sci., 2016, 7, 4245-4250.

59. Youyong Yuan, Chong-Jing Zhang, Shidang Xu and Bin Liu*, A Self-Reporting Aie Probe With A Built-In Singlet Oxygen Sensor For Targeted Photodynamic Ablation Of Cancer Cells. Chem. Sci., 2016, 7, 1862-1866.

60. Shidang Xu, Youyong Yuan, Xiaolei Cai, Chong-Jing Zhang, Fang Hu, Jing Liang, Guanxin Zhang, Deqing Zhang, Bin Liu*, Tuning the Singlet-Triplet Energy Gap: Unique Approach to Efficient Photosensitizers with Aggregation-Induced Emission (AIE) Characteristics. Chem. Sci., 2015, 6, 5824-5830.

61. Youyong Yuan, Ryan T. K. Kwok, Ben Zhong Tang*, and Bin Liu*, Smart Probe for Tracing Cancer Therapy: Selective Cancer Cell Detection, Image-Guided Ablation, and Prediction of Therapeutic Response in Situ. Small, 2015, 11, 4682–4690.

62. Youyong Yuan, Dan Ding, Kai Li, Jie Liu, Bin Liu*, Tumor-responsive Fluorescent Light-up Probe based on a Gold Nanoparticle/Conjugated Polyelectrolyte Hybrid. Small, 2014, 10, 1967-1975.

63. Youyong Yuan, Jin-Zhi Du, Wen-Jing Song, Feng Wang, Xian-Zhu Yang, Meng-Hua Xiong, Jun Wang*, Biocompatible and Functionalizable Polyphosphate Nanogels with A Branched Structure. J. Mater Chem., 2012, 22, 9322-9329.

64. Youyong Yuan, Shidang Xu, Chong-Jing Zhang, Ruoyu Zhang, Bin Liu*, Dual-targeted Activatable Photosensitizer with Aggregation-Induced Emission (AIE) Characteristics for Image-Guided Photodynamic Cancer Therapy. J. Mater. Chem. B, 2016, 4, 169-176.

65. Youyong Yuan, Zuyong Wang, Pinqiang Cai, Jie Liu, Lunde Liao, Minghui Hong, Xiaodong Chen, Nitish Thakord and Bin Liu*, Conjugated Polymer and Drug Co-encapsulated Nanoparticles for Chemo-and Photo-thermal Combination Therapy with Two-Photon Regulated Fast Drug Release. Nanoscale, 2015, 7, 3067-3076.

66. Youyong Yuan, Yuanzeng Min, Qinglian Hu, Bengang Xing, Bin Liu*, NIR Photoregulated On-demand Chemo-Photodynamic Cancer Therapy based on Upconversion Nanoparticles/Conjugated Polyelectrolyte Hybrid. Nanoscale, 2014, 6, 11259-11272.

67. Youyong Yuan, and Bin Liu*, Self-Assembled Nanoparticles Based on PEGylated Conjugated Polyelectrolyte and Drug Molecules for Image-Guided Drug Delivery and Photodynamic Therapy. ACS Appl. Mater. Interfaces, 2014, 6, 14903-14910.

68. Youyong Yuan, Chong-Jing Zhang, Bin Liu*, A Platinum Prodrug Conjugated with a Photosensitizer with Aggregation-Induced Emission (AIE) Characteristics for Drug Activation Monitoring and Combinatorial Photodynamic–Chemotherapy against Cisplatin Resistant Cancer Cells. Chem. Commun., 2015, 51, 8626-8629.

69. Youyong Yuan, Guangxue Feng, Wei Qin, Ben Zhong Tang, Bin Liu*, Targeted and Image-Guided Photodynamic Cancer Therapy based on Organic Nanoparticles with Aggregation-Induced Emission Characteristics. Chem. Commun., 2014, 50, 8757-8760.

70. Youyong Yuan, Ryan T. K. Kwok, Guangxue Feng, Jing Liang, Junlong Geng, Ben Zhong Tang*, Bin Liu*, Rational Design of Fluorescent Light-up Probes based on an AIE Luminogen for Targeted Intracellular Thiol Imaging. Chem. Commun., 2014, 50, 295-297.

71. Youyong Yuan, Yilong Chen, Ben Zhong Tang*, Bin Liu*, A Targeted Theranostic Platinum (IV) Prodrug Containing a Luminogen with Aggregation-Induced Emission (AIE) Characteristics for In Situ Monitoring of Drug Activation. Chem. Commun., 2014, 50, 3868-3870.

72. Youyong Yuan, Ryan T. K. Kwok, Ruoyu Zhang, Ben Zhong Tang*, Bin Liu*, Targeted Theranostic Prodrug Based on an Aggregation-Induced Emission (AIE) Luminogen for Real-Time Dual-Drug Tracking. Chem. Commun., 2014, 50, 11465-11468.

73. Youyong Yuan, Jinzhi Du, and Jun Wang*, Two Consecutive Click Reactions as a General Route to Functional Cyclic Polyesters, Chem. Commun., 2012, 48, 570-572.

74. Youyong Yuan, Shidang Xu, Chong-Jing Zhang, Bin Liu*, Light-Responsive AIE Nanoparticles With Cytosolic Drug Release To Overcome Drug Resistance In Cancer Cells, Polym. Chem., 2016, 7, 3530-3539.