Recently, Professor Huang Mingtao's team at SCUT conducted research on key processes of endoplasmic reticulum targeting and transmembrane transport in Saccharomyces cerevisiae. They elucidated the functional role of Sec72, a subunit of the Sec complex, in the entry of signal peptide-mediated proteins into the endoplasmic reticulum and proposed a secretion enhancement strategy based on Sec72 deletion. The findings were published in the journal Research under the title The Absence of Sec72 Reshapes Yeast Cell Functions to Increase Protein Secretion.

Redesign of intracellular pathways based on Sec72 deficiency synergistically enhances protein secretion

South China University of Technology is the sole affiliated institution for this achievement. Xue Songlyu, a doctoral candidate from the School of Food Science and Engineering, along with postdoctoral researchers Pan Yuyang and Qin Ling, are listed as co-first authors. Professor Huang Mingtao serves as the corresponding author. In recent years, Professor Huang Mingtao's team has achieved multiple research advances in optimizing protein secretion efficiency in Saccharomyces cerevisiae. Related findings have been published in journals including Adv. Sci., PNAS, Nat. Commun., Metab. Eng., and ACS Synth. Biol.

This research was supported by the National Natural Science Foundation of China, the National Key Research and Development Program, and the Guangzhou Municipal Science and Technology Program.

Related results link: https://spj.science.org/doi/10.34133/research.1119

Source：SCUT News

Translated by SHI Weipeng

Reviewed by AN Yufan