Lecture: Versatile Therapeutic Applications of Glycosaminoglycans From Antivirals to Cancer Immunotherapy
Time: 2th December, Monday, 15:00 – 17:00
Venue: Dongtang Hall, Building 13
Speaker: Dr. So Young Kim, University of California, San Diego
Welcome all the teachers and students to attend！
Report Summaries:
The most widely used anticoagulant in clinical medicine, heparin, is a type of naturally occurring polysaccharides called glycosaminoglycans (GAGs). GAGs are involved in various biological processes including in cellular signaling, pathogenesis, and immunity. My research focuses on identifying the roles of GAGs in human health and diseases and developing GAG-based therapeutic strategies. In this talk, I will discuss how chondroitin sulfate GAG facilitates vertical transmission of Zika virus and the novel designer glycoconjugates on the DNA origami nanoscaffolds as antivirals. In the second part of the talk, I will reveal the regulatory functions of heparan sulfate GAG on dendritic cells in the tumor microenvironment and their therapeutic potential as cancer immunotherapy
