Dear teachers and fellow students，

        “Global Forum for Excellent Young Scholar” welcomes young talents with different academic background around the world, to discuss frontier and hot research topics with the hope of creating a platform for both SCUT and young scholars to promote international exchanges and cooperation.The arrangement of the forum is as below：

 1.Time

    9：00 am，May 15，2017

2.Venue

DongTang Conference Room, Building #13

3.Agenda

     （1）9：00—9：05   Welcome Speech

     （2）9：05—9：35    Speaker：Dr.  Wuyuan Zhang, Technische Universiteit Delft.

Title:   Selective aerobic oxidation reactions via combination of photocatalytic water oxidation and enzymatic oxyfunctionalisations

Contents：

Peroxygenases offer attractive means to address challenges in selective oxyfunctionalisation chemistry. Despite their attractiveness, the application of peroxygenases in synthetic chemistry remains challenging due to their facile inactivation by the stoichiometric oxidant (H2O2). To address this, we show that inorganic water oxidation catalysts can be used for light-driven in situ generation of H2O2 from water to promote selective oxyfunctionalisation reactions catalysed by peroxygenases. The generality of this approach is illustrated by the (1) selective conversion of (non-)activated alkanes into chiral alcohols, (2) the chemoenzymatic halogenation of phenols and (3) the multi-enzyme cascade transformation of alkanes into chiral amines and acyloins.

     （3）9：35—10：00   Speaker：Dr. Wenwen Chen, Nanyang Technological University.

 Title:    The coarse-graining method: theory and biomolecular application

Contents：

The molecular dynamics simulations are nowadays widely used in the biotechnology related industry. It can help to provide a better understanding of the biomolecules’ structure and function at the atomic-level, which would be difficult to observe experimentally with the traditional method. However, many biological processes occur on time scale far beyond the capabilities of atomistic molecular simulations. Consequently, the coarse grained models are getting increasingly popular since they are able to deal with the range of spatio-temporal scales involved in cellular processes. Many coarse grained models have been successfully applied to capture the key behaviors of biological macromolecules such as protein folding, membrane transport and the conformational transitions associated with protein function. Based on the above-mentioned background, I will hereby present two coarse graining modeling topics in this talk. The first one is to give an introduction of the development of coarse-graining method. I will explain how two knowledge-based coarse grained models are derived from protein databank bank and used to simulate the protein folding and protein-protein interactions, respectively. Another topic is to discuss the application of the coarse grained modeling study of Human beta defensins with POPG membrane.

       Welcome to attend!