讲座主题：From New Synthetic Methodologies and Self-Organizations to mRNA-Based Thrapeutics and Vaccines

报告人：Virgil Percec（瑞典皇家科学院外籍院士、罗马尼亚科学院外籍院士、宾夕法尼亚大学教授）

报告时间：2025年12月13日上午9：00-10：30

报告地点：广州国际校区C1-b115

邀请人：程正迪院士

邀请单位：前沿软物质学院

报告摘要：

Our laboratory is involved in the development of new synthesis methodologies and new concepts demanded to design complex molecular systems. After a brief discussion of all topics of research from our laboratory, this lecture will present several new synthethic methods elaborated in our laboratory, followed by their use in the design of several new self-organizations. The  lecture will conclude with a discussion of the development of amphiphilic Janus densrimers assembling dendrimersomes as mimics of the cell membrane, amphiphilic Janus glycodendrimers with self-assemble glycodendrimersomes, as mimics of the gycans of the cell membranes, and last but not least, the discovery and development of one component systems for the targeted delivery of mRNA as well as  the development of therapeutics and vaccines based on one-component delivery systems.

个人简介：

Virgil Percec was born and educated in Romania. He defected his native country in 1981 and after short postdoctoral stays at the Institute of Macromolecular Chemistry, Hermann Staudinger House of the University of Freiburg, Germany and Institute of Polymer Science of the University of Akron, USA, he joined the Department of Macromolecular Science of Case Western Reserve University, Cleveland, USA in March 1982 as an Assistant Professor. He bacame Associate Professor in 1984 and full Professor in 1986. In 1993 he was awarded the Leonard Case Jr. Chair Professor. In 1999, he was invited to join the Department of Chemistry at the University of Pennsylvania, Philadelphia as the inaugural P. Roy Vagelos Chair and Professor of Chemistry. Percec’s current scientific activities cover organic and macromolecular synthesis, supramolecular chemistry, self-assembly, biological mimics, complex systems, biological membranes, origins, amplification and transfer of chirality, supramolecular chirality, liquid crystals, supramolecular electronics, nanoscience and other cross-disciplinary research fields, where he contributed over 844 refereed publications, 220 patents and 20 books.

He pioneered the fields of stereoisomers of substituted polyacetylenes, the transplant of phase transfer catalysis from organic to polymer chemistry, and is known for the discovery and development of molecular and supramolecular liquid crystals with complex architecture, Nickel-catalyzed cross-couplings, mixed-ligand effects, catalytic effect of solvent, SET-LRP, self-organizable dendrons, dendrimers and dendronized polymers, complex functional systems by using Nature as a model and biological principles, soft Frank-Kasper phases and qusicrystals. Most recently he developed the concepts of amphiphilic Janus dendrimers, Janus glycodendrimers and one-component ionizable amphiphilic Janus dendrimers for the targeted delivery of mRNA.  Percec presented over 1320 endowed, plenary and invited lectures. He has been Editor of Journal of Polymer Science: Part A: Polymer Chemistry, Advances in Polymer Science and the Book Series “Liquid Crystals”.

Percec serves on Editorial and Advisory Scientific Boards of 24 International Journals, and of Academic and Industrial Institutions on 5 continents. Percec was elected member of 4 Academies, received numerous awards including 3 Doctor Honoris Causa, organized numerous International Symposia including IUPAC and Gordon Research Conferences in US and Europe. Percec has been teaching at Universities in Europe, Australia, Asia and America. He educated over 300 PhD and postdoctoral students, 75 of them being University Professors some of them being also University Presidents and CEO of Companies around the world.