Yanrui Ye
Email: esyanruiye@scut.edu.cn
Education and working experience
2000-2004 South China University of Technology Biological Engineering B.Sc.
2004-2009 South China University of Technology Fermentation Engineering Ph.D
2010-2013 South China University of Technology Biochemical Engineering Postdoctoral Researcher
2013-2014 South China University of Technology Pharmaceutical Biology, Lecturer
2014- South China University of Technology Fermentation Engineering, Pharmaceutical Biology Associate professor
Research interests
Combined with Omic techniques, research in our group focuses on developing synthetic biology tools and strategies to understand and harness transcriptional regulation and translational quality control in microorganisms. The goal is to enable high performance of these microbial cell factories in food, commodity and pharmaceutical industries. Specifically, our group focuses on designing and constructing new chassises of Gram positive bacteria and yeasts, based on design principles of synthetic biology, to produce value-added products and bioactive molecules.
Representative projects
Effect and mechanisms of Vitreoscilla hemoglobin on the oxygen uptake rate in Pichia pastoris. 2011-2013. National Natural Science Funds of China, Principle Investigator
The improvement effect of Vitreoscilla hemoglobin on the oxygen uptake rate in Pichia pastoris cells, 2012-2014，National Science Foundation for Post-doctoral Scientists of China, Principle Investigator
Cell wall proteome and methanol stress responses in Pichia pastoris, 2012-2015, National Natural Science Funds of China, Member.
Molecular modeling and catalyzation analysis of β-glucosidase fusion protein system, 2012-2015, National Natural Science Funds of China, Member.
Identification and analysis of acquired heavy-chain antibody immune response using deep sequencing and proteomic techniques, 2014-2015, SCUT-BGI innovative funding, Member.
Analysis of the targets of action of the new lipid-lowering drug R-bambuterol, 2014-2017, the Fundamental Research Funds for the Central Universities, Principle Investigator.
Pre-clinical study of the new lipid-lowering drug R-bambuterol, 2014-2017, Major Program of Science and Technology Planning Project of Guangdong Province, Member.
Representative articles
Liu, X., Yang, H., Ye, Y., & Pan, L. (2017). Identification of strong promoters based on the transcriptome of Bacillus licheniformis. Biotechnology Letters, 1-9.
Li, X., Duan, X., Yang, K., Zhang, W., Zhang, C., Fu, L., ... & Ye, Y. (2016). Comparative Analysis of Immune Repertoires between Bactrian Camel's Conventional and Heavy-Chain Antibodies. PloS one, 11(9), e0161801.
Ye, Y., Xu, H., Quan, L., Zhu, L., Zeng, J., Zhou, T., ... & Tan, W. (2015). The lipid-lowering effects of R-bambuterol in healthy Chinese volunteers: a randomized phase I clinical study. EBioMedicine, 2(4), 356-364.
Liang, S., Wang, B., Pan, L., Ye, Y., He, M., Han, S., ... & Lin, Y. (2012). Comprehensive structural annotation of Pichia pastoris transcriptome and the response to various carbon sources using deep paired-end RNA sequencing. BMC genomics, 13(1), 738.
Liang, S., Li, C., Ye, Y., & Lin, Y. (2013). Endogenous signal peptides efficiently mediate the secretion of recombinant proteins in Pichia pastoris. Biotechnology letters, 35(1), 97-105.
Liang, S., Zou, C., Lin, Y., Zhang, X., & Ye, Y. (2013). Identification and characterization of PGCW14: a novel, strong constitutive promoter of Pichia pastoris. Biotechnology letters, 35(11), 1865-1871.
Liang, S., Lin, Y., Li, C., & Ye, Y. (2012). Internal ribosome entry site mediates protein synthesis in yeast Pichia pastoris. Biotechnology letters, 34(5), 957-964.
Lin, X. Q., Liang, S. L., Han, S. Y., Zheng, S. P., Ye, Y. R., & Lin, Y. (2013). Quantitative iTRAQ LC–MS/MS proteomics reveals the cellular response to heterologous protein overexpression and the regulation of HAC1 in Pichia pastoris. Journal of proteomics, 91, 58-72.
Zhang, X., Zhang, X., Liang, S., Ye, Y., & Lin, Y. (2013). Key regulatory elements of a strong constitutive promoter, PGCW14, from Pichiapastoris. Biotechnology letters, 35(12), 2113-2119.
Ye, Y., Zhu, Y., Pan, L., Li, L., Wang, X., & Lin, Y. (2009). Gaining insight into the response logic of Saccharomyces cerevisiae to heat shock by combining expression profiles with metabolic pathways. Biochemical and biophysical research communications, 385(3), 357-362.
Others
Motivated students with backgrounds of biological science and/or biological engineering are welcome to contact Yanrui Ye at esyanruiye@scut.edu.cn with a CV and a brief description of scientific interests.
