Name：Xiaorong Yang Ph.D.
Email：birxyang@scut.edu.cn
Education
May 2003 - February 2007 Ph. D., Institute of Physical Chemistry, University of Stuttgart, Germany
September 2000 - March 2003M. S., Institute of Chemistry, Chinese Academy of Sciences, China
September 1992 - July 1996B. E., Chemical Engineering College, Chong-Qing University, China
Working experience
October 2014 — presentAssociate Professor，School of Bioscience and Bioengineering, South China University of Technology,China
August 2010 — September 2014 Research Scientist, Department of Chemistry, Pennsylvania State University, USA
August 2008 — July 2010Post-doctoral Scholar，Department of Chemistry, Pennsylvania State University, USA
May 2006— February 2007Teaching Assistant，Institute of Physical Chemistry, University of Stuttgart, Germany
July 1996— May 2000Technicianat Chong-Qing San-Xia Paint Group Co. Ltd., China
Research interests：
The structure, dynamics and function of the enzyme；The interaction between the enzyme and its ligands
Funding as a principle investigator：
1. The mechanic analysis of ThermusThermophilus laccase (LacTT) catalyzing dyestuffs decolorization based on NMR techniqueNational Natural Science foundation of China 2017.1 – 2020.12.
2. The ability enhancement of ThermusThermophilus laccase (LacTT) catalyzing dyestuffs decolorization based on the mechanical analysisGuangzhou Science and Technology and Innovation Commission2016.4 – 2018.3
3.The mechanism of electron transfer during the catalytic cycle of ThermusThermophilus laccase (LacTT) Guangdong Provincial Key Laboratory of Fermentation and EnzymeEngineering, South China University of Technology,2017.1 – 2017.12
4. The molecular mechanism of ThermusThermophilus laccase (LacTT) interacting with the substrates The Key Laboratory of Renewable Energy, Chinese Academy of Sciences 2015.1 – 2016.12
Representative articles：
[1] Xiaorong Yang*, Conformational dynamics play important rolesupon the function of N-acetylglutamate kinase, ApplMicrobiolBiotechnol, 2017, 101(9), 3485-3492.
[2] Xiaorong Yang, Xinran Liu, Derek M. Musser, Ibrahim M Moustafa, Jamie J. Arnold, Craig E. Cameron and David D. Boehr,Triphosphate Reorientation of the Incoming Nucleotide as a Fidelity Checkpoint in Viral RNA-dependent RNA Polymerases, J Biol Chem. 2017, 292(9), 3810-3826.
[3] Yuanyuan Huang, Cheng Li, Hao Zhang, Shuli Liang, Shuangyan Han, Ying Lin,Xiaorong Yang*, Suiping Zheng, Monomeric Corynebacterium glutamicum N-acetyl glutamate kinase maintains sensitivity to L-arginine but has a lower intrinsic catalytic activity,ApplMicrobiolBiotechnol, 2016, 100(4), 1789-1798.
[4] Xinran Liu, Derek M. Musser, Cheri A. Lee,Xiaorong Yang, Jamie J. Arnold,Craig E. Cameron and David D. Boehr,Nucleobase but not Sugar Fidelity is Maintained inthe Sabin I RNA-Dependent RNA Polymerase, Viruses, 2015, 7, 5571-5586.
[5] David D Boehr, Xinran Liu, Xiaorong Yang, Targeting structural dynamics of the RNA-dependent RNA polymerase for anti-viral strategies. CurrOpinVirol. 2014, 9, 194-200.
[6] Xinran Liu, Xiaorong Yang (co-first author), Cheri A. Lee, Ibrahim M. Moustafa, Eric D. Smidansky, David Lum, Jamie J. Arnold, Craig E. Cameron, David D. Boehr, Vaccine-derived mutation in motif D of poliovirus RNA-dependent RNA polymerase lowers nucleotide incorporation fidelity, J Biol. Chem. 2013, 288, 32753-65.
[7] Xiaorong Yang, Eric D. Smidansky, Kenneth R. Maksimchuk, David Lum, Jesse L. Welch, Jamie J. Arnold, Craig E. Cameron, David D. Boehr, Motif D of viral RNA-dependent RNA polymerases determines efficiency and fidelity of nucleotide addition, Structure, 2012, 20, 1519-1527.
[8] Xiaorong Yang*, Klaus Müller, The guest ordering and dynamics in urea inclusion compounds studied by solid state 1H and 13C MAS NMR spectroscopy, J. Mol. Struct. 2011, 1006, 113-120.
[9] Xiaorong Yang*, Klaus Müller, The structural and dynamic properties of 1-bromodecane in urea inclusion compounds investigated by solid state 1H, 13C and 2H NMR spectroscopy, Magn. Reson. Chem. 2011, 49, 514-522.
[10] Xiaorong Yang, Jesse L. Welch, Jamie J. Arnold, David D. Boehr, Long-range interaction networks in the function and fidelity of poliovirus RNA-dependent RNA polymerase studied by nuclear magnetic resonance, Biochemistry, 2010, 49, 9361-9371.
Ph D Thesis Book：
Xiaorong Yang, Solid-State NMR Studies of the Guest Molecules in Urea Inclusion Compounds, Logos Verlag, Berlin, ISBN 978-3-8325-1533-1.
