Name: WANG BIN
Diploma: Doctor of Engineering
Enrollment field: Microbiology, Biotechnology;Qualified for accepting exam-exempted postgraduates
Research field: Fungal natural product biosynthesis and regulation; Industrial biotechnology; Aspergillus genetics and physiology
E-mail: btbinwang@scut.edu.cn
Education and occupational experience
2013.09 to date Associate professor, South China University of Technology, Guangzhou
2010.09-2013.08 Lecturer, South China University of Technology, Guangzhou
2004.09-2010.06 PhD., Fermentation Engineering, South China University of Technology, Guangzhou
2000.09-2004.06 Bachelor (Bioscience), QUFU Normal University, Shandong
Research interests and main achievements
Interest I: Fungal natural product biosynthesis and regulation
We focus on fungal natural secondary metabolites with potential valuable usage in medicine, and investigate essential scientific issues related with the biosynthesis, heterologous expression and molecular regulation mechanisms about such secondary metabolites. Combined with genetic manipulation and genome-scale functional analysis, we aim to activate abundant silent secondary metabolic gene clusters to induce novel metabolites, which could contribute to exploring active natural products and providing lead compounds for drug exploration. Ongoing and accomplished research projects in this field include: (1) Association analysis of aflatoxin biosynthesis and sclerotial development in Aspergillus flavus based on transcriptome sequencing (supported by National Natural Science Foundation of China, NSFC); (2) Epigenetic modification mechanism on regulating filamentous fungal secondary metabolite biosynthesis and its application (supported by Science and Technology Program of Guangzhou, China); (3) Mechanism study of secondary metabolite biosynthesis in filamentous Aspergillus niger regulated by epigenetic modification (supported by Fundamental Research Funds for the Central Universities, China).
Interest II: Industrial biotechnology; Aspergillus genetics and physiology
We focus on filamentous fungal strains widely used in industrial fields such as food, fermentation and textile, including Aspergillus oryzae, A. niger, A. flavus and so on. We investigate the essential scientific issues related with fungal protein expression and its regulation mechanisms. The aim is to construct effective filamentous fungal protein expression systems, in order to solve the practical problems in the industrial production related with food, fermentation and textile, according to national developmental requirements. Ongoing and accomplished research projects in this field include: (1) Effective large-scale production and application of Porcine circovirus capsid protein vaccine in Aspergillus niger (supported by Science and Technology Planning Project of Guangdong Province); (2) Screening and improvement of novel enzymes applied in food processing (supported by Hi-tech Research and Development program of China, 863 program); (3) Biological preparation of food base grease without trans fatty acids and its application (supported by Science and Technology Planning Project of Guangdong Province).
Main achievements
In the recent five years, I have been in charge of seven scientific research projects and participated in six research projects. 21 articles have been published in the following journals: Nucleic Acids Research (SCI IF: 9.1), BMC Genomics (SCI IF: 4.4), Gene (SCI IF: 2.1), Plos One (SCI IF: 3.2), Journal of bacteriology (SCI IF: 3.7), Biotechnology letters (SCI IF: 1.85), Acta Microbiologica Sinica and Microbiology China. Among these articles, I am the first authors or corresponding authors for 12 of them. 12 articles are indexed by Science Citation Index (SCI), reaching a total SCI impact factor of 44.92 and cited times of 130. I participated in the construction of Guangdong provincial engineering research center for biological enzyme and industrial green processing. As the primary teacher, I organized the following courses: Fermentation engineering, Modern industrial microbiology, Gene engineering, Introduction to biological science and engineering, Molecular cloning experimental techniques and System biology. I participated in writing two books: Food fermentation engineering, and Enzyme engineering.
Representative research projects
[1] National Natural Science Foundation of China (NSFC) project (No. 31100026; Principal Investigator): Association analysis of aflatoxin biosynthesis and sclerotial development in Aspergillus flavus based on transcriptome sequencing (2012.01-2014.12; ¥220,000)
[2] Science and Technology Planning Project of Guangdong Province (No. 2016A010105004; Principal Investigator): Effective large-scale production and application of Porcine circovirus capsid protein vaccine in Aspergillus niger (2016.01-2018.12; ¥300,000)
[3] Science and Technology Program of Guangzhou (No. 201510010191; Principal Investigator): Epigenetic modification mechanism on regulating filamentous fungal secondary metabolite biosynthesis and its application (2015.07-2017.12; ¥200,000)
[4] Fundamental Research Funds for the Central Universities (No. 2015ZZ040; Principal Investigator): Mechanism study of secondary metabolite biosynthesis in filamentous Aspergillus niger regulated by epigenetic modification (2015.01-2016.12; ¥200,000)
[5] Natural science foundation of Guangdong province project (No. S2011040003020; Principal Investigator): Transcriptome analysis of sclerotial development in Aspergillus flavus (2011.10-2013.09; ¥30,000)
[6] Enterprise entrusted application project (No. D8141830; Principal Investigator): Optimization of papain immobilization preparation process and its application (2014.05-2017.05; ¥100,000)
[7] Hi-tech Research and Development program of China (863 program No. 2011AA100905; Participant): Screening and improvement of novel enzymes applied in food processing (2011.01-2015.12)
[8] Science and Technology Planning Project of Guangdong Province (No. 2012B010900028; Participant): Biological preparation of food base grease without trans fatty acids and its application (2013.01-2016.12)
[9] Hi-tech Research and Development program of China (863 program No. 2012AA022108; Participant): Genome-level improvement of microorganisms used in food industry (2012.01-2015.12)
[10] National Natural Science Foundation of China (NSFC) project (No. 30970045; Participant): Endoplasmic reticulum stress response mechanism in filamentous fungal protein secretion pathway (2010.01-2012.12)
Representative publications
[1] Bin Wang, Guangwu Guo, Chao Wang, Ying Lin, Xiaoning Wang, Mouming Zhao, Yong Guo, Minghui He, Yong Zhang, Li Pan: Survey of the transcriptome of Aspergillus oryzae via massively parallel mRNA sequencing. Nucleic acids research 2010, 38(15): 5075-5087. (SCI IF: 7.5, Times Cited: 108)
[2] Chao Wang, Yangyong Lv, Bin Wang, Chao Yin, Ying Lin, Li Pan: Survey of protein-DNA interactions in Aspergillus oryzae on a genomic scale. Nucleic acids research 2015, 43(9): 4429-4446. (Joint first author, SCI IF: 9.1)
[3] Bin Zhou, Jingyi Xie, Xiaokai Liu, Bin Wang, Li Pan: Functional and transcriptomic analysis of the key unfolded protein response transcription factor HacA in Aspergillus oryzae. Gene 2016, 593(1): 143-153. (Corresponding author, SCI IF: 2.1)
[4] Yuling Liao, Lianggang Huang, Bin Wang, Feng Zhou, Li Pan: The global transcriptional landscape of Bacillus amyloliquefaciens XH7 and high-throughput screening of strong promoters based on RNA-seq data. Gene 2015, 571(2): 252-262. (Corresponding author, SCI IF: 2.1)
[5] Xinliang Wu, Bin Zhou, Chao Yin, Yong Guo, Ying Lin, Li Pan, Bin Wang：Characterization of natural antisense transcript, sclerotia development and secondary metabolism by strand-specific RNA sequencing of Aspergillus flavus. Plos One, 2014, 9(5): e97814. (Corresponding author, SCI IF: 3.2, Times Cited:7)
[6] Chao Yin, Bin Wang, Pan He, Ying Lin, Li Pan: Genomic analysis of the aconidial and high-performance protein producer, industrially relevant Aspergillus niger SH2 strain. Gene 2014, 541(2): 107-114. (Joint first author, SCI IF: 2.1)
[7] Shuli Liang, Bin Wang, Li Pan, Yanrui Ye, Minghui He, Shuangyan Han, Suiping Zheng, Xiaoning Wang, Ying Lin: Comprehensive structural annotation of Pichia pastoris transcriptome and the response to various carbon sources using deep paired-end RNA sequencing. BMC Genomics 2012, 13: 738. (Joint first author, SCI IF: 4.4, Times Cited:18)
[8] Yuling Liao, Li Pan, Bin Wang: Construction of Single-stranded Oligonucleotide-mediated Homologous Recombination in Bacillus amyloliquefaciens. Modern food science and technology 2016, 32(8): 96-102. (Corresponding author, EI)
[9] Xiang Li, Li Pan, Bin Wang: Influence of aflatoxin on Vibrio fischeri luminescence. Acta Microbiologica Sinica 2011, 51(12): 1669-1674. (Corresponding author)
[10] Bin Wang, Li Pan, Yong Guo: Construction of heterologous gene expression system for filamentous Aspergillus oryzae. Journal of South China University of Technology 2009, 37(6):84-89. (EI)
Patents
[1] Li Pan, Bin Zhou, Haiyan Yang, Yuling Liao, Bin Wang. Simple device used for nucleic acid extraction via vacuum method (No. 201620421622.6, authorized)
