Quhuan Li

Tel:+86-15811879359

Email:liqh@scut.edu.cn

Research field: Cellular and Molecular Biomechanics, Physiology, Bioinformatics

A. Education and work experience

B. Teaching experience

Courses for undergraduates:Molecular Biology, Experiment of Molecular Biology, Biochemistry and Molecular Biology, Bioinformatics, Developmental Biology, MolecularGenetics；Courses for graduates: Cellular and Molecular Biomechanics, Experimental Techniques of Biomechanics, Cellular Immunology.

C. Research interests

Currently, our interests lie in adhesion and signaling molecules involved in processes of inflammation, hemostasis, and cancer metastasis. We use several experimental (Parallel-plate flow chamber, PPFC) and computational (Molecular dynamics simulation, MD), and theoretical (Modeling) methods to study the mechanics and kinetics of cell and molecular interactions at the cellular and molecular levels. Ultimately, our researches strives to help better understanding of the mechanisms within these systems for possible medical applications in autoimmunity, allergy, transplant rejection, and thrombotic disorders.

D. Grants

2017-2018Fundamental Research Funds for the Central Universities (Key Program). The force-dependent regulation mechanism of lymphocyte homingmediated by integrin α4β7/MAdCAM-1 interaction.

2015-2016 Open Funds of Guangdong Provincial Key Laboratory of Fermentation and Enzyme Engineering. Study of force-regulated mechanism for enzyme kinetics behavior of ADAMTS-13.

2015-2016 Development funds for young teacher of School of Bioscience and Bioengineering Study of force-regulated mechanism for LFA-1 activity mediated by E-selectin.

2014-2015 Fundamental Research Funds for the Central Universities. (Key Program). The kinetic study of αvβ3/FN interaction regulated by force.

2013-2015 Natural Science Foundation of China. The force-dependent regulation mechanism of integrin αvβ3/Fibronectin interaction.

2011-2013 Specialized Research Fund for the Doctoral Program of Higher Education.Flow-enhanced platele adhesion regulated by interaction of GPIbα-VWF.

2011-2012 Foundation for Distinguished Young Talents in Higher Education of Guangdong. The mechanism study of flow-enhanced platele adhesion under flow.

2010-2011SCUT Natural Science Funds for Young Scholar. The study of flow-enhanced cellular rollingly adhesion mediated by E-selectin.

2010-2011 Fundamental Research Funds for the Central Universities. (General Program)The study for mechanism of integrin activation mediated by selectin under flow.

Publications

Li Q., Wayman A., Lin J., Fang Y., Zhu C., Wu J..Flow-Enhanced Stability of Rolling Adhesion through E-Selectin. Biophys J. 2016,111(4):686-99.（First author）

Li Q., Lin Q., Yun Z..Hypoxia-activated cytotoxicity of benznidazole against clonogenic tumor cells. Cancer Biology & Therapy.2016 Oct 27.DOI: 10.1080/15384047.2016.1250988. Online.（First author）

Li Q., Zhang J., Ling Y., Huang B.,Fang Y.. A method for surface E-selectin site density determination.Frontiers in Life Science. 2015,8(3):294-9.（First author）

Li Q., Zhang J.,Fang Y..Comparison of two methods for surface E-selectin site density determination. Journal of Investigative Medicine. 2015. 63(1):197-8.（First author）

Liu Z., Zhang J., Cai M., Li N., Luo X., Xing H., LiQ..Bioinformatics analysis of integrin αvβ3. ITME.  2015. 1:53-56. DOI: 10.1109/ITME.2015.105. （Corresponding author）

Li N.,Li Q.Identification and characterization of endogenous viral elements for  the three key schistosomes of humans.Pakistan Journal of Pharmaceutical Sciences.2014.375-81.（Corresponding author）

Ling Y., Fang Y., Yang X., Li Q., Lin Q., Wu J., Regulation of shear stress on rolling behaviors of HL-60 cells on P-selectin. Science China: Physics, Mechanics and Astronomy. 2014, 57(10):1998-2006.DOI: 10.1007/s11433-013-5270-7.

Li Q.; Fang Y.; Ding X.; Wu J.. Force-dependent bond dissociation govern rolling of HL-60 cells through E-selectin. Experimental Cell Research. 2012. 318(14):1649-58. DOI: 10.1016/j.yexcr.2012.05.018. （First author）

Li Q.. SARP: A comprehensive design platform for studying structure-activity relationship of antimicrobial peptides. ITME. 2011.1:606-9. DOI: 10.1109/ITiME.2011.6130911.（First author）

Gu S.; Zeng Y.; Lai W.;Li Q.. Protein interaction network prediction and pathways analyses related atherosclerosis. ICBBE. 2011.DOI: 10.1109/icbbe.2011.5780048. （Corresponding author）

Acadamic honors

2010First Prize of the Youth Academic Paper Contest. Guangdong Society of Biomedical Engineering. Title of this paper: The study of flow-enhanced rollingly adhesion mediated by E-selectin.

2006 International Visiting Graduate Student Award.The American Association of Biophysics.

Teaching honors

2015 Excellence Award for Undergraduate Teaching

2015 Teaching Award of School of Bioscience and Bioengineering

2014Third Prize, Excellent Guide Teacher Awardfor Undergraduate Innovation Research, SCUT.

2013 Excellent adviser, National Undergraduates Innovating Experimentation Project

2013Excellent adviser, Graduation Thesis/Design ofUndergraduate, SCUT

2012 Excellent adviser, Graduation Thesis/Design ofUndergraduate, SCUT

2011 Third Prize, Undergraduate Teaching Competition for Youth Teacher, Molecular Genetics, SCUT.

2011Third Prize, Excellent Guide Teacher Awardfor Undergraduate Innovation Research, SCUT.